1. Apoptosis
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  3. Notopterol

Notopterol 

Cat. No.: HY-N0564
Handling Instructions

Notopterol is a coumarin extracted from N. incisum. Notopterol induces apoptosis and has antipyretic, analgesic and anti-inflammatory effects. Notopterol is used for acute myeloid leukemia (AML).

For research use only. We do not sell to patients.

Notopterol Chemical Structure

Notopterol Chemical Structure

CAS No. : 88206-46-6

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Description

Notopterol is a coumarin extracted from N. incisum. Notopterol induces apoptosis and has antipyretic, analgesic and anti-inflammatory effects. Notopterol is used for acute myeloid leukemia (AML)[1].

In Vitro

notopterol (5, 10, 20, 40, 60 μM; for 48 hours) promotes cell apoptosis in a dose-dependent manner[1].
notopterol (10, 20, 40, 60 and 80 μM; 24-120 hours) inhibits the proliferation of HL-60 cells in a concentration-dependent manner[1].
Notopterol (5, 10, 20 and 40 μM; for 48 hours) induces G0/G1 phase arrest associated with cell-cycle proteins in HL-60 cells[1].
Notopterol (5, 10, 20 and 40 μM; for 48 hours) increases the expression of Bax and decreased the expression of Bcl-2 and Mcl-1 in HL-60 cells after 48-hr treatment. Moreover, Notopterol also promotes the cleavage of caspase 9, caspase 3 and PARP[1].

Molecular Weight

354.40

Formula

C₂₁H₂₂O₅

CAS No.

88206-46-6

SMILES

O=C1C=CC2=C(OC/C=C(C)/CC(O)/C=C(C)/C)C3=C(OC=C3)C=C2O1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

NotopterolApoptosisCoumarinantipyreticanalgesicanti-inflammatoryacutemyeloidleukemiaAMLInhibitorinhibitorinhibit

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