2. Neuronal Signaling Stem Cell/Wnt Apoptosis
  3. γ-secretase Apoptosis
  4. Itanapraced

Itanapraced  (Synonyms: CHF5074; CSP-1103)

Cat. No.: HY-14399 Purity: 99.37%
COA Handling Instructions

Itanapraced (CHF5074) is an orally active γ-secretase modulator and a non-steroidal anti-inflammatory derivative. Itanapraced reduces Aβ42 and Aβ40 secretion with IC50 values of 3.6 and 18.4 μM, respectively. Itanapraced inhibits cell apoptosis of hippocampal neurons induced by oxygen and glucose deprivation (OGD). Itanapraced can be used for the research of Alzheimer's disease.

For research use only. We do not sell to patients.

Itanapraced Chemical Structure

Itanapraced Chemical Structure

CAS No. : 749269-83-8

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10 mM * 1 mL in DMSO
ready for reconstitution
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10 mg USD 140 In-stock
25 mg USD 280 In-stock
50 mg USD 440 In-stock
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Based on 1 publication(s) in Google Scholar

Itanapraced Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Itanapraced

  • Biological Activity

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  • References

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Description

Itanapraced (CHF5074) is an orally active γ-secretase modulator and a non-steroidal anti-inflammatory derivative. Itanapraced reduces Aβ42 and Aβ40 secretion with IC50 values of 3.6 and 18.4 μM, respectively. Itanapraced inhibits cell apoptosis of hippocampal neurons induced by oxygen and glucose deprivation (OGD). Itanapraced can be used for the research of Alzheimer's disease[1][2].

IC50 & Target

IC50 value: 3.6 μM (Aβ42), 18.4 μM (Aβ40)[1]
In Vitro

Itanapraced (0.03-100 μM) inhibits Aβ secretion in human neuroglioma cells (H4swe) expressing APPswe with IC50 values of 3.6 and 18.4 μM for Aβ42 and Aβ40, respectively[1].
Itanapraced (5-200 μM) inhibits Notch processing in HEK293swe cells with concentrations over 15 μM[1].
Itanapraced (0-1000 μM; 30 min) dose-dependently inhibits the action potential with an IC50 value of 106 μM[2].
Itanapraced (30-100 μM) dose-dependently inhibits excitatory synaptic transmission[2].
Itanapraced (1-10 μM) significantly reduces cell apoptosis in hippocampal neurons induced by oxygen and glucose deprivation (OGD)[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Itanapraced Related Antibodies
In Vivo

Itanapraced (oral administration; 375 ppm in the diet for 17 weeks) decreases Aβ42 and Aβ40 levels, and brain plaque burden in Tg2576 transgenic mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male and female Tg2576 transgenic mice expressing Swedish mutated form of human APP (APPswe)[1]
Dosage: 375 ppm
Administration: Oral administration; 375 ppm in the diet for 17 weeks
Result: Reduced total brain Aβ42 and Aβ40 levels, and brain plaque burden in aged Tg2576 mice. Caused no COX-mediated toxic effects in the gastrointestinal tract and Notch-mediated cell differentiation abnormalities in the ileum.
Clinical Trial
Molecular Weight

325.16

Appearance

Solid

Formula

C16H11Cl2FO2
CAS No.
SMILES

OC(C1(CC1)C(C=C2)=CC(F)=C2C3=CC=C(Cl)C(Cl)=C3)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (307.54 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.0754 mL 15.3770 mL 30.7541 mL
5 mM 0.6151 mL 3.0754 mL 6.1508 mL
10 mM 0.3075 mL 1.5377 mL 3.0754 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: 2.5 mg/mL (7.69 mM); Suspended solution; Need ultrasonic

  • 2.

    Add each solvent one by one:  10% DMSO    90% Corn Oil

    Solubility: ≥ 2.5 mg/mL (7.69 mM); Clear solution

*All of the co-solvents are available by MedChemExpress (MCE).
Purity & Documentation

Purity: 99.37%

COA (247 KB) HNMR (146 KB) RP-HPLC (248 KB) LCMS (259 KB)

Handling Instructions (2659 KB)
References
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Itanapraced Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Keywords:

Itanapraced749269-83-8CHF5074 CSP-1103CHF 5074CHF-5074CSP1103CSP 1103CSP-1103γ-secretaseApoptosisGamma secretaseAβ42Aβ40Alzheimer's diseaseH4sweNotch processingapoptosisxcitatory synaptic transmissionInhibitorinhibitorinhibit

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