1. Neuronal Signaling
    Stem Cell/Wnt
  2. γ-secretase
  3. Itanapraced

Itanapraced (Synonyms: CHF5074; CSP-1103)

Cat. No.: HY-14399 Purity: >98.0%
Handling Instructions

Itanapraced (CHF5074) is a novel γ-secretase modulator, reduces Aβ42 and Aβ40 secretion, with an IC50 of 3.6 and 18.4 μM, respectively.

For research use only. We do not sell to patients.

Itanapraced Chemical Structure

Itanapraced Chemical Structure

CAS No. : 749269-83-8

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 121 In-stock
Estimated Time of Arrival: December 31
5 mg USD 110 In-stock
Estimated Time of Arrival: December 31
10 mg USD 160 In-stock
Estimated Time of Arrival: December 31
50 mg USD 550 In-stock
Estimated Time of Arrival: December 31
100 mg USD 800 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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  • Technical Information

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Description

Itanapraced (CHF5074) is a novel γ-secretase modulator, reduces Aβ42 and Aβ40 secretion, with an IC50 of 3.6 and 18.4 μM, respectively.

IC50 & Target

IC50 value: 3.6 μM (Aβ42), 18.4 μM (Aβ40) [1]

Clinical Trial
Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 37 mg/mL (113.79 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.0754 mL 15.3770 mL 30.7541 mL
5 mM 0.6151 mL 3.0754 mL 6.1508 mL
10 mM 0.3075 mL 1.5377 mL 3.0754 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

325.16

Formula

C₁₆H₁₁Cl₂FO₂

CAS No.

749269-83-8

SMILES

OC(C1(CC1)C(C=C2)=CC(F)=C2C3=CC=C(Cl)C(Cl)=C3)=O

Shipping

Room temperature in continental US; may vary elsewhere

Purity: >98.0%

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This equation is commonly abbreviated as: C1V1 = C2V2

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Product Name:
Itanapraced
Cat. No.:
HY-14399
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Itanapraced

Cat. No.: HY-14399