MyD88-IN-1
Based on 5 publication(s) in Google Scholar
MyD88-IN-1 (Compound c17) is an orally active MyD88 inhibitor. MyD88-IN-1 inhibits the interaction of TLR4 and MyD88 and suppressed the NF-κB pathway. MyD88-IN-1 can be used in research of cancer and inflammatory.
For research use only. We do not sell to patients.
- Purity: 98.38%
- CAS No.: 2911609-80-6
- Formula: C23H24N6O7S
- Molecular Weight:528.54
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Immunology/Inflammation Compound Library
HY-L007
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NF-κB Signaling Compound Library
HY-L014
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Anti-Cancer Compound Library
HY-L025
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Orally Active Compound Library
HY-L061
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Anti-Obesity Compound Library
HY-L087
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Bioactive Compound Library Max
HY-L181
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MCE Bioactive Compound Library
HY-L001V
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Bioactive Compound Library
HY-L001
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High-Throughput Bioactive Compound Library
HY-L205
Publications Citing Use of MedChemExpress (MCE) MyD88-IN-1
More
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| J774.A1 | IC50 |
2.17 μM
Compound: c17
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Anti-inflammatory activity in mouse J774.A1 cells assessed as inhibition of LPS-induced IL-6 production pre-stimulated with LPS for 24 hrs followed by compound addition and measured after 0.5 hrs by ELISA analysis
Anti-inflammatory activity in mouse J774.A1 cells assessed as inhibition of LPS-induced IL-6 production pre-stimulated with LPS for 24 hrs followed by compound addition and measured after 0.5 hrs by ELISA analysis
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[PMID: 37130331] |
| J774.A1 | IC50 |
8.17 μM
Compound: c17
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Anti-inflammatory activity in mouse J774.A1 cells assessed as inhibition of LPS-induced TNF-alpha production pre-stimulated with LPS for 24 hrs followed by compound addition and measured after 0.5 hrs by ELISA analysis
Anti-inflammatory activity in mouse J774.A1 cells assessed as inhibition of LPS-induced TNF-alpha production pre-stimulated with LPS for 24 hrs followed by compound addition and measured after 0.5 hrs by ELISA analysis
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[PMID: 37130331] |
MyD88-IN-1 (10 μM, 24 h) exhibits significant anti-inflammatory effects in LPS (HY-D1056)-induced J774A.1 macrophages[1]. MyD88-IN-1 (40 or 80 μM, 2 h) restores IκB-α expression and inhibits p65 phosphorylation and nuclear translocation, indicating that it exerts anti-inflammatory effects by suppressing the NF-κB signaling pathway[1]. MyD88-IN-1 (40 or 80 μM, 2 h) exerts its anti-inflammatory activity in J774A.1 macrophages by inhibiting TLR4-MyD88 interaction[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:J774A.1 macrophages (mouse-derived)
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Concentration:40 μM, 80 μM
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Incubation Time:2 h
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Result:Restored IκB-α expression, inhibited p65 phosphorylation and nuclear translocation.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:LPS (HY-D1056)-induced acute lung injury (ALI) in C57BL/6L mice[1]
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Dosage:20 mg/kg
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Administration:Oral gavage (p.o.), single dose, Administered 30 minutes before LPS induction
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Result:Significantly reduced TNF-α and IL-6 levels in BALF and serum; Decreased wet/dry lung ratio and total protein concentration; Alleviated lung tissue histopathological changes.
Chemical Information
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CAS No. 2911609-80-6
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Appearance Solid
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Molecular Weight 528.54
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Formula C23H24N6O7S
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Color Yellow to orange
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SMILES
O=[N+](C1=CC=CC(CN2CCN(CC2)C3=CC=C(S(=O)(NC4=CN=C(C=C4)OC)=O)C=C3[N+]([O-])=O)=C1)[O-]
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (5)
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Journal Impact Factor
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Most Recent
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J Extracell Vesicles
Extracellular Vesicles Derived From Streptococcus anginosus Aggravate Lupus Nephritis by Triggering TLR2-MyD88-NF-κB Signalling in NK Cells. [Abstract]2025 Jul;14(7):e70134. PMID: 40673809 -
Adv Sci (Weinh)
Activated Platelet-Released Heat Shock Protein 90α Triggers Autophagy-Dependent Neutrophil Extracellular Trap Formation and Amplifies Sepsis. [Abstract]2026 May;13(25):e15933. PMID: 41732887 -
Adv Sci (Weinh)
VDLIN: A Deep Learning-Based Platform for Methylcobalamin-Inspired Immunomodulatory Compound Screening. [Abstract]2025 Oct 27:e13775. PMID: 41144841 -
Phytomedicine
Shen-Shuai-Ⅱ Recipe ameliorates chronic kidney disease-induced myocardial injury via inhibition of the IL-18/IL-18R1/MyD88 pathway. [Abstract]2026 Mar:152:157877. PMID: 41621346 -
Solvent & Solubility
DMSO : 100 mg/mL (189.20 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (273 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.8920 mL | 9.4600 mL | 18.9200 mL | 47.3001 mL |
| 5 mM | 0.3784 mL | 1.8920 mL | 3.7840 mL | 9.4600 mL | |
| 10 mM | 0.1892 mL | 0.9460 mL | 1.8920 mL | 4.7300 mL | |
| 15 mM | 0.1261 mL | 0.6307 mL | 1.2613 mL | 3.1533 mL | |
| 20 mM | 0.0946 mL | 0.4730 mL | 0.9460 mL | 2.3650 mL | |
| 25 mM | 0.0757 mL | 0.3784 mL | 0.7568 mL | 1.8920 mL | |
| 30 mM | 0.0631 mL | 0.3153 mL | 0.6307 mL | 1.5767 mL | |
| 40 mM | 0.0473 mL | 0.2365 mL | 0.4730 mL | 1.1825 mL | |
| 50 mM | 0.0378 mL | 0.1892 mL | 0.3784 mL | 0.9460 mL | |
| 60 mM | 0.0315 mL | 0.1577 mL | 0.3153 mL | 0.7883 mL | |
| 80 mM | 0.0237 mL | 0.1183 mL | 0.2365 mL | 0.5913 mL | |
| 100 mM | 0.0189 mL | 0.0946 mL | 0.1892 mL | 0.4730 mL |
MyD88-IN-1 Related Classifications
HY-149992 Related Classifications
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