1. Immunology/Inflammation
    Apoptosis
  2. Glucocorticoid Receptor
    Apoptosis
  3. Flunisolide hemihydrate

Flunisolide hemihydrate 

Cat. No.: HY-B1121A
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Flunisolide hemihydrate is a corticosteroid, which is an orally active glucocorticoid receptor activator with anti-inflammatory activity. Flunisolide hemihydrate can induce eosinophil apoptosis, and is used for the research of asthma or rhinitis, and inflammation.

For research use only. We do not sell to patients.

Flunisolide hemihydrate Chemical Structure

Flunisolide hemihydrate Chemical Structure

CAS No. : 77326-96-6

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Description

Flunisolide hemihydrate is a corticosteroid, which is an orally active glucocorticoid receptor activator with anti-inflammatory activity. Flunisolide hemihydrate can induce eosinophil apoptosis, and is used for the research of asthma or rhinitis, and inflammation[1][2].

In Vitro

Flunisolide hemihydrate (0.1-10 μM, 1 h) inhibits lung fibroblast (Isolated from lung) activation[1].
Flunisolide hemihydrate (10 μM, 24 h) reduces MMP-9, TIMP-1, TGF-β and fibronectin release by sputum cells (isolated from mild to moderate asthmatics), and induces sputum eosinophil apoptosis[2].
Flunisolide hemihydrate (0.1-10 µM μM, 24 h) effectively inhibits ICAM-1 expression and GM-CSF and IL-5 release induced by TNF-alpha in BEAS-2B cells[3].
Flunisolide hemihydrate (115 µM, 0-3 h) can be transported in a polarized way in the apical (ap) to basolateral (bl) direction in Calu-3 cells and is demonstrated to be ATP-dependent[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Apoptosis Analysis[2]

Cell Line: Eosinophil
Concentration: 10 μM
Incubation Time: 24 h
Result: Induced sputum eosinophil apoptosis.
In Vivo

Flunisolide hemihydrate (Intranasal administration, 0.3-10 µg/mouse, daily, from days 21–27) inhibits lung inflammation, fibrosis, and airway hyper-reactivity, also improves clearance of silica particles from the lungs in silicotic mice[1].
Flunisolide hemihydrate (Intranasal administration, 0.3-10 µg/mouse, daily, from days 21–27) inhibits silica-induced macrophage and myofibroblast accumulation in the lung tissue[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Swiss Webster mice (instilled, intranasally, with crystalline silica, 10 mg/50 µL, particle size 0.5-10 µm)[1]
Dosage: 0.3-10 µg/mouse, daily, from days 21–27
Administration: Intranasal administration
Result: Reduced both granulomatous response, collagen deposition, concerning granuloma formation caused by silica particles.
Reduced the number of F4/80 and α-SMA positive cells.
Molecular Weight

443.51

Formula

C24H31FO6.1/2H2O

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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Flunisolide hemihydrate
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