1. Immunology/Inflammation
    Apoptosis
  2. Glucocorticoid Receptor
    Apoptosis
  3. Flunisolide

Flunisolide 

Cat. No.: HY-B1121 Purity: 99.95%
COA Handling Instructions

Flunisolide is a corticosteroid, which is an orally active glucocorticoid receptor activator with anti-inflammatory activity. Flunisolide can induce eosinophil apoptosis, and is used for the research of asthma or rhinitis, and inflammation.

For research use only. We do not sell to patients.

Flunisolide Chemical Structure

Flunisolide Chemical Structure

CAS No. : 3385-03-3

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Flunisolide:

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Flunisolide

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Flunisolide is a corticosteroid, which is an orally active glucocorticoid receptor activator with anti-inflammatory activity. Flunisolide can induce eosinophil apoptosis, and is used for the research of asthma or rhinitis, and inflammation[1][2].

In Vitro

Flunisolide (0.1-10 μM, 1 h) inhibits lung fibroblast (Isolated from lung) activation[1].
Flunisolide (10 μM, 24 h) reduces MMP-9, TIMP-1, TGF-β and fibronectin release by sputum cells (isolated from mild to moderate asthmatics), and induces sputum eosinophil apoptosis[2].
Flunisolide (0.1-10 µM μM, 24 h) effectively inhibits ICAM-1 expression and GM-CSF and IL-5 release induced by TNF-alpha in BEAS-2B cells[3].
Flunisolide (115 µM, 0-3 h) can be transported in a polarized way in the apical (ap) to basolateral (bl) direction in Calu-3 cells and is demonstrated to be ATP-dependent[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Apoptosis Analysis[2]

Cell Line: Eosinophil
Concentration: 10 μM
Incubation Time: 24 h
Result: Induced sputum eosinophil apoptosis.
In Vivo

Flunisolide (Intranasal administration, 0.3–10 µg/mouse, daily, from days 21-27) inhibits lung inflammation, fibrosis, and airway hyper-reactivity, also improves clearance of silica particles from the lungs in silicotic mice[1].
Flunisolide (Intranasal administration, 0.3–10 µg/mouse, daily, from days 21-27) inhibits silica-induced macrophage and myofibroblast accumulation in the lung tissue[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Swiss Webster mice (instilled, intranasally, with crystalline silica, 10 mg/50 µL, particle size 0.5-10 µm)[1]
Dosage: 0.3-10 µg/mouse, daily, from days 21–27
Administration: Intranasal administration
Result: Reduced both granulomatous response, collagen deposition, concerning granuloma formation caused by silica particles.
Reduced the number of F4/80 and α-SMA positive cells.
Clinical Trial
Molecular Weight

434.50

Formula

C24H31FO6

CAS No.
SMILES
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (287.69 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3015 mL 11.5075 mL 23.0150 mL
5 mM 0.4603 mL 2.3015 mL 4.6030 mL
10 mM 0.2301 mL 1.1507 mL 2.3015 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (4.79 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (4.79 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (4.79 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation

Purity: 99.95%

References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
Flunisolide
Cat. No.:
HY-B1121
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