1. GPCR/G Protein
  2. Adenosine Receptor
  3. Adenosine A1 receptor activator T62

Adenosine A1 receptor activator T62 

Cat. No.: HY-106199
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Adenosine A1 receptor activator T62 is an allosteric enhancer of adenosine A1 receptor. Adenosine A1 receptor activator T62 produces antinociception in animal models of acute pain and also reduces hypersensitivity in models of inflammatory and nerve-injury pain.

For research use only. We do not sell to patients.

Adenosine A1 receptor activator T62 Chemical Structure

Adenosine A1 receptor activator T62 Chemical Structure

CAS No. : 40312-34-3

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10 mM * 1 mL in DMSO USD 417 In-stock
Estimated Time of Arrival: December 31
5 mg USD 390 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

Adenosine A1 receptor activator T62 is an allosteric enhancer of adenosine A1 receptor. Adenosine A1 receptor activator T62 produces antinociception in animal models of acute pain and also reduces hypersensitivity in models of inflammatory and nerve-injury pain[1][2][3].

IC50 & Target

Adenosine A1 receptor[1]

In Vivo

Adenosine A1 receptor activator T62 (0.3-3 μg; intrathecal administration; male SpragueDawley rats) treatment produces a dose-dependent antihypersensitivity effect, with no effect on ambulation or activity level[1].

Animal Model: Male SpragueDawley rats (250 g) after paw incision surgery[1]
Dosage: 0.3 μg, 0.5 μg, 1 μg, and 3 μg
Administration: Intrathecal administration
Result: Produced a dose-dependent antihypersensitivity effect, with no effect on ambulation or activity level. The ED40 (95% confidence interval) was 0.77 (0.63-0.91) μg.
Molecular Weight

291.80

Formula

C₁₅H₁₄ClNOS

CAS No.

40312-34-3

SMILES

O=C(C1=CC=C(Cl)C=C1)C2=C(N)SC3=C2CCCC3

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Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

Adenosine A1 receptor activator T62Adenosine ReceptorP1 receptorEnhancerallostericadenosinehypersensitivityneuropathicantihypersensitivityα2-adrenoceptorsintrathecalInhibitorinhibitorinhibit

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Adenosine A1 receptor activator T62
Cat. No.:
HY-106199
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