Adenosine A1 receptor activator T62
Based on 1 publication(s) in Google Scholar
Adenosine A1 receptor activator T62 is an allosteric enhancer of adenosine A1 receptor. Adenosine A1 receptor activator T62 produces antinociception in animal models of acute pain and also reduces hypersensitivity in models of inflammatory and nerve-injury pain.
For research use only. We do not sell to patients.
- Purity: 98.93%
- CAS No.: 40312-34-3
- Formula: C15H14ClNOS
- Molecular Weight:291.80
-
Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
-
Solvent & Solubility
- Purity & Documentation
- References
-
Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Adenosine A1 receptor activator T62
MoreAll Adenosine Receptor Isoforms
More
Biological Activity
Adenosine A1 receptor[1]
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:Male SpragueDawley rats (250 g) after paw incision surgery[1]
-
Dosage:0.3 μg, 0.5 μg, 1 μg, and 3 μg
-
Administration:Intrathecal administration
-
Result:Produced a dose-dependent antihypersensitivity effect, with no effect on ambulation or activity level. The ED40 (95% confidence interval) was 0.77 (0.63-0.91) μg.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
-
CAS No. 40312-34-3
-
Appearance Solid
-
Molecular Weight 291.80
-
Formula C15H14ClNOS
-
Color Light yellow to yellow
-
SMILES
O=C(C1=CC=C(Cl)C=C1)C2=C(N)SC3=C2CCCC3
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (1)
-
Journal Impact Factor
-
Most Recent
Solvent & Solubility
DMSO : 100 mg/mL (342.70 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
-
Data Sheet (273 KB)
-
SDS (396 KB)
- English - EN (396 KB)
- Français - FR (396 KB)
- Deutsch - DE (396 KB)
- Norwegian - NO (396 KB)
- Español - ES (396 KB)
- Swedish - SV (396 KB)
- Italian - IT (396 KB)
- Korean - KR (396 KB)
- Portuguese - PT (396 KB)
-
Handling Instructions (2659 KB)
References
[1]. Obata H, et al. Spinal adenosine receptor activation reduces hypersensitivity after surgery by a different mechanism than after nerve injury. Anesthesiology. 2004 May;100(5):1258-62. [Content Brief]
[2]. Li X, et al. Allosteric adenosine receptor modulation reduces hypersensitivity following peripheral inflammation by a central mechanism. J Pharmacol Exp Ther. 2003 Jun;305(3):950-5. [Content Brief]
[3]. Soudijn W, et al. Allosteric modulation of G protein-coupled receptors: perspectives and recent developments. Drug Discov Today. 2004 Sep 1;9(17):752-8. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.4270 mL | 17.1350 mL | 34.2700 mL | 85.6751 mL |
| 5 mM | 0.6854 mL | 3.4270 mL | 6.8540 mL | 17.1350 mL | |
| 10 mM | 0.3427 mL | 1.7135 mL | 3.4270 mL | 8.5675 mL | |
| 15 mM | 0.2285 mL | 1.1423 mL | 2.2847 mL | 5.7117 mL | |
| 20 mM | 0.1714 mL | 0.8568 mL | 1.7135 mL | 4.2838 mL | |
| 25 mM | 0.1371 mL | 0.6854 mL | 1.3708 mL | 3.4270 mL | |
| 30 mM | 0.1142 mL | 0.5712 mL | 1.1423 mL | 2.8558 mL | |
| 40 mM | 0.0857 mL | 0.4284 mL | 0.8568 mL | 2.1419 mL | |
| 50 mM | 0.0685 mL | 0.3427 mL | 0.6854 mL | 1.7135 mL | |
| 60 mM | 0.0571 mL | 0.2856 mL | 0.5712 mL | 1.4279 mL | |
| 80 mM | 0.0428 mL | 0.2142 mL | 0.4284 mL | 1.0709 mL | |
| 100 mM | 0.0343 mL | 0.1714 mL | 0.3427 mL | 0.8568 mL |
Adenosine A1 receptor activator T62 Related Classifications
HY-106199 Related Classifications
Powered by Bioz