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Safranal 

Cat. No.: HY-N7560 Purity: >90.0%
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Safranal is an orally active main component of Saffron (Crocus sativus) and is responsible for the unique aroma of this spice. Safranal has neuroprotective and anti-inflammatory effects and has the potential for Parkinson’s disease research.

For research use only. We do not sell to patients.

Safranal Chemical Structure

Safranal Chemical Structure

CAS No. : 116-26-7

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Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

Safranal is an orally active main component of Saffron (Crocus sativus) and is responsible for the unique aroma of this spice. Safranal has neuroprotective and anti-inflammatory effects and has the potential for Parkinson’s disease research[1].

In Vitro

Safranal (10-50 μM; for 1 h) dose-dependently decreases LPS-induced iNOS and COX-2 levels in both RAW264.7 cells and BMDMs[1].
Safranal (10-50 μM; for 1 h) inhibits cytokine IL-6 and TNF-α production and mRNA expression in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells[1].
Safranal (10, 50 μM; for 1 h followed by stimulation with 1 μg/ml of LPS for 30 min) inhibits the nuclear translocation of NF-κB and AP-1 in lipopolysaccharide (LPS)-stimulated RAW264.7 cells[1].

Western Blot Analysis[1]

Cell Line: RAW264.7 cells and bone marrow-derived macrophages (BMDMs)
Concentration: 10, 50 μM
Incubation Time: For 1 h prior to lipopolysaccharide (LPS) stimulation (1 µg/ml)
Result: Dose-dependently decreased LPS-induced iNOS and COX-2 levels in both RAW264.7 cells and BMDMs.
Inhibited the phosphorylation of MAPK pathway proteins extracellular signal-regulated kinase (ERK), c-Jun N-terminal kinase (JNK), p38.
Inhibited NF-κB pathway proteins IKKα/β and IκBα and the degradation of IκBα.

RT-PCR[1]

Cell Line: RAW 264.7 cells
Concentration: 10, 50 μM
Incubation Time: For 1 h followed by stimulation with LPS (1 μg/ml) for 24 h
Result: Inhibited cytokine IL-6 and TNF-α production and mRNA expression in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells.
In Vivo

Safranal (200-500 mg/kg; PO; for 7 days) causes a slight restoration of colon length and percentage of weight loss, and the DAI score is significantly low[1].

Animal Model: Female BALB/c mice (18-20 g) (DSS-induced colitis mice)[1]
Dosage: 200, 500 mg/kg
Administration: PO; for 7 days
Result: Caused a slight restoration of colon length and percentage of weight loss, and the DAI score is significantly low.
Molecular Weight

150.22

Formula

C₁₀H₁₄O

CAS No.

116-26-7

SMILES

O=CC1=C(C)C=CCC1(C)C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

References
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Keywords:

SafranalOthersorallySaffronneuroprotectiveanti-inflammatoryParkinson’sdiseaseInhibitorinhibitorinhibit

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