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Safranal 

Cat. No.: HY-N7560 Purity: 98.04%
COA Handling Instructions

Safranal is an orally active main component of Saffron (Crocus sativus) and is responsible for the unique aroma of this spice. Safranal has neuroprotective and anti-inflammatory effects and has the potential for Parkinson’s disease research.

For research use only. We do not sell to patients.

Safranal Chemical Structure

Safranal Chemical Structure

CAS No. : 116-26-7

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500 mg USD 50 In-stock
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This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 5 publication(s) in Google Scholar

Top Publications Citing Use of Products

2 Publications Citing Use of MCE Safranal

IF
WB
RT-PCR

    Safranal purchased from MedChemExpress. Usage Cited in: Phytomedicine. 2023 Mar 5.

    Safranal (Saf; 5, 10, 20 μM; 6 days) inhibits RANKL-induced overproduction of osteoclast-related mRNAs (Acp5, CTSK, Atp6v0d2, c-Fos) in BMMs.

    Safranal purchased from MedChemExpress. Usage Cited in: Phytomedicine. 2023 Mar 5.

    Safranal (Saf; 20 μM; 1, 3, 5 days) inhibits RANKL-induced overproduction of osteoclast-related osteo-resorptive proteins (V-ATPase-d2 and CTSK) in BMMs.

    Safranal purchased from MedChemExpress. Usage Cited in: Phytomedicine. 2023 Mar 5.

    Safranal (Saf; 5, 10, 20 μM; 6 days) suppresses RANKL-increased numbers of TRAcP-positive multinucleated osteoclasts in a concentration-dependent manner, in BMMs.
    • Biological Activity

    • Purity & Documentation

    • References

    • Customer Review

    Description

    Safranal is an orally active main component of Saffron (Crocus sativus) and is responsible for the unique aroma of this spice. Safranal has neuroprotective and anti-inflammatory effects and has the potential for Parkinson’s disease research[1].

    In Vitro

    Safranal (10-50 μM; for 1 h) dose-dependently decreases LPS-induced iNOS and COX-2 levels in both RAW264.7 cells and BMDMs[1].
    Safranal (10-50 μM; for 1 h) inhibits cytokine IL-6 and TNF-α production and mRNA expression in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells[1].
    Safranal (10, 50 μM; for 1 h followed by stimulation with 1 μg/ml of LPS for 30 min) inhibits the nuclear translocation of NF-κB and AP-1 in lipopolysaccharide (LPS)-stimulated RAW264.7 cells[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Western Blot Analysis[1]

    Cell Line: RAW264.7 cells and bone marrow-derived macrophages (BMDMs)
    Concentration: 10, 50 μM
    Incubation Time: For 1 h prior to lipopolysaccharide (LPS) stimulation (1 µg/ml)
    Result: Dose-dependently decreased LPS-induced iNOS and COX-2 levels in both RAW264.7 cells and BMDMs.
    Inhibited the phosphorylation of MAPK pathway proteins extracellular signal-regulated kinase (ERK), c-Jun N-terminal kinase (JNK), p38.
    Inhibited NF-κB pathway proteins IKKα/β and IκBα and the degradation of IκBα.

    RT-PCR[1]

    Cell Line: RAW 264.7 cells
    Concentration: 10, 50 μM
    Incubation Time: For 1 h followed by stimulation with LPS (1 μg/ml) for 24 h
    Result: Inhibited cytokine IL-6 and TNF-α production and mRNA expression in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells.
    In Vivo

    Safranal (200-500 mg/kg; PO; for 7 days) causes a slight restoration of colon length and percentage of weight loss, and the DAI score is significantly low[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Female BALB/c mice (18-20 g) (DSS-induced colitis mice)[1]
    Dosage: 200, 500 mg/kg
    Administration: PO; for 7 days
    Result: Caused a slight restoration of colon length and percentage of weight loss, and the DAI score is significantly low.
    Molecular Weight

    150.22

    Formula

    C10H14O

    CAS No.
    Appearance

    Liquid

    Color

    Light yellow to yellow

    SMILES

    O=CC1=C(C)C=CCC1(C)C

    Structure Classification
    Initial Source
    Shipping

    Room temperature in continental US; may vary elsewhere.

    Storage

    -20°C, stored under nitrogen

    *In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

    Solvent & Solubility
    In Vitro: 

    DMSO : 100 mg/mL (665.69 mM; Need ultrasonic)

    Ethanol : 100 mg/mL (665.69 mM; Need ultrasonic)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 6.6569 mL 33.2845 mL 66.5690 mL
    5 mM 1.3314 mL 6.6569 mL 13.3138 mL
    10 mM 0.6657 mL 3.3285 mL 6.6569 mL
    *Please refer to the solubility information to select the appropriate solvent.
    In Vivo:
    • 1.

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

      Solubility: ≥ 2.5 mg/mL (16.64 mM); Clear solution

    • 2.

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

      Solubility: 2.5 mg/mL (16.64 mM); Suspended solution; Need ultrasonic

    • 3.

      Add each solvent one by one:  10% DMSO    90% Corn Oil

      Solubility: ≥ 2.5 mg/mL (16.64 mM); Clear solution

    • 4.

      Add each solvent one by one:  10% EtOH    40% PEG300    5% Tween-80    45% Saline

      Solubility: ≥ 2.5 mg/mL (16.64 mM); Clear solution

    • 5.

      Add each solvent one by one:  10% EtOH    90% (20% SBE-β-CD in Saline)

      Solubility: 2.5 mg/mL (16.64 mM); Suspended solution; Need ultrasonic

    • 6.

      Add each solvent one by one:  10% EtOH    90% Corn Oil

      Solubility: ≥ 2.5 mg/mL (16.64 mM); Clear solution

    *All of the co-solvents are available by MedChemExpress (MCE).
    Purity & Documentation

    Purity: 98.04%

    References
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    Safranal Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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    Product Name:
    Safranal
    Cat. No.:
    HY-N7560
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