1. Apoptosis
    Metabolic Enzyme/Protease
  2. Apoptosis
    Endogenous Metabolite
  3. Taurochenodeoxycholic acid sodium salt

Taurochenodeoxycholic acid sodium salt (Synonyms: 12-Deoxycholyltaurine sodium salt)

Cat. No.: HY-N1429 Purity: >97.0%
Handling Instructions

Taurochenodeoxycholic acid sodium salt (12-Deoxycholyltaurine sodium salt) is one of the main bioactive substances of animals' bile acid. Taurochenodeoxycholic acid induces apoptosis and shows obvious anti-inflammatory and immune regulation properties.

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Taurochenodeoxycholic acid sodium salt Chemical Structure

Taurochenodeoxycholic acid sodium salt Chemical Structure

CAS No. : 6009-98-9

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Description

Taurochenodeoxycholic acid sodium salt (12-Deoxycholyltaurine sodium salt) is one of the main bioactive substances of animals' bile acid. Taurochenodeoxycholic acid induces apoptosis and shows obvious anti-inflammatory and immune regulation properties[1][2].

IC50 & Target[1][2]

Human Endogenous Metabolite

 

In Vitro

Taurochenodeoxycholic acid dramatically improves the apoptosis rate of NR8383 cells in a concentration-dependent manner. In the meantime, Taurochenodeoxycholic acid significantly augments PKC mRNA levels, activities and increases JNK, caspase-3 and caspase-8 mRNA expression levels, activities[1].

In Vivo

Taurochenodeoxycholic acid (0.05, 0.1g/kg) decreases the pulmonary coefficient in the model mice and reduces the pathological damages on their lungs; it can decrease the expression levels of TNF-α and TIMP-2 in pulmonary tissues in the pulmonary fibrosis mice and has no significant effects on MMP2[2].
Taurochenodeoxycholic acid significantly normalizes the clinical inflammatory parameters, prevented indomethacin-induced increases in the biliary contents of secondary bile acids and hydrophobicity index, and tended to attenuate the intestinal inflammation[3].
Taurochenodeoxycholic acid significantly suppresses paw swelling and polyarthritis index, increases the loss body weight and index of thymus and spleen, and amends radiologic changes in AA rats. The overproduction and mRNA expression of TNF-α, IL-1β and IL-6 are remarkably suppressed in serum and synovium tissue of all TCDCA-treated rats[4].

Molecular Weight

521.69

Formula

C₂₆H₄₄NNaO₆S

CAS No.

6009-98-9

SMILES
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (191.68 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9168 mL 9.5842 mL 19.1685 mL
5 mM 0.3834 mL 1.9168 mL 3.8337 mL
10 mM 0.1917 mL 0.9584 mL 1.9168 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (4.79 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (4.79 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (4.79 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: >97.0%

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Keywords:

Taurochenodeoxycholic acid12-DeoxycholyltaurineApoptosisEndogenous Metabolitebileacidanti-inflammatoryimmuneregulationNR8383PKCmRNAJNKcaspase-3caspase-8TNF-αTIMP-2Inhibitorinhibitorinhibit

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Taurochenodeoxycholic acid sodium salt
Cat. No.:
HY-N1429
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