2. Anti-infection Stem Cell/Wnt PI3K/Akt/mTOR Cell Cycle/DNA Damage Epigenetics
  3. Antibiotic GSK-3 Bacterial Aurora Kinase
  4. Ceftriaxone sodium salt

Ceftriaxone sodium salt  (Synonyms: Ro 13-9904)

Cat. No.: HY-B0712B Purity: 99.90%
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Ceftriaxone sodium salt (Ro 13-9904) is a broad spectrum β-lactam third-generation cephalosporin antibiotic, which has good antibacterial activity against a variety of gram-negative and positive bacteria. Ceftriaxone sodium salt is a covalent inhibitor of GSK3β with IC50 value of 0.78 μM. Ceftriaxone sodium salt is an inhibitor of Aurora B. Ceftriaxone sodium salt has anti-inflammatory, antitumor and antioxidant activities. Ceftriaxone sodium salt can be used in the study of bacterial infections and meningitis.

For research use only. We do not sell to patients.

CAS No. : 74578-69-1

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Customer Review

Based on 16 publication(s) in Google Scholar

Other Forms of Ceftriaxone sodium salt:

Ceftriaxone sodium salt Related Antibodies

Top Publications Citing Use of Products

    Ceftriaxone sodium salt purchased from MedChemExpress. Usage Cited in: AMB Express. 2024 Dec 24;14(1):141.  [Abstract]

    Combinational antimicrobial effects between PVB and conventional antibiotics against MRSA ATCC 43,300. TET, Tetracycline. DOX, Doxycycline. E, Erythromycin. AZI, Azithromycin. P, Penicillin. CAZ, Ceftazidime. AMP, Ampicillin. CEZ, Cefazolin. CEF, Cefotaxime. OXA, Oxacillin. CRO, Ceftriaxone. AMK, Amikacin. GEN, Gentamycin, KANA, Kanamycin. TOB, Tobramycin. SPC, Spectinomycin.

    View All Antibiotic Isoform Specific Products:

    View All Isoforms
    Aminoglycoside Glycopeptide Lipopeptide Macrolide Oxazolidinone Quinolone Tetracycline β-lactam

    View All GSK-3 Isoform Specific Products:

    View All Isoforms
    GSK-3 GSK-3α GSK-3β

    View All Aurora Kinase Isoform Specific Products:

    View All Isoforms
    Aurora Kinase Aurora A Aurora B Aurora C

    • Biological Activity

    • Purity & Documentation

    • References

    • Customer Review

    Description

    Ceftriaxone sodium salt (Ro 13-9904) is a broad spectrum β-lactam third-generation cephalosporin antibiotic, which has good antibacterial activity against a variety of gram-negative and positive bacteria. Ceftriaxone sodium salt is a covalent inhibitor of GSK3β with IC50 value of 0.78 μM. Ceftriaxone sodium salt is an inhibitor of Aurora B. Ceftriaxone sodium salt has anti-inflammatory, antitumor and antioxidant activities. Ceftriaxone sodium salt can be used in the study of bacterial infections and meningitis[1][2][3][4][5][6][7].

    IC50 & Target

    β-lactam

     

    In Vitro

    Ceftriaxone sodium salt (100 μM, 24 h) protects MPP+ treated astrocytes by inhibiting the NF-κB/JNK/c-Jun signaling pathway [3].
    Ceftriaxone sodium salt (500 μM, 24-48 h) effectively inhibits unanchored cell growth in A549, H520 and H1650 lung cancer cells by inhibiting Aurora B[4].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Ceftriaxone sodium salt Related Antibodies

    Cell Viability Assay[3]

    Cell Line: Astrocyte
    Concentration: 100 μM
    Incubation Time: 24 h
    Result: Improved cell viability and increased glutamate uptake after MPP+ expose.

    Western Blot Analysis[3]

    Cell Line: Astrocyte
    Concentration: 100 μM
    Incubation Time: 24 h
    Result: Enhanced GLT-1 and GFAP expression.
    Decreased the expression of p-p50、p-IKKα、p-Relb.
    Decreased the number of TUNEL-positive cells.
    In Vivo

    Ceftriaxone sodium salt (200 mg/kg Intraperitoneal injection for 6 weeks) improves functional markers and oxidative stress and inflammation parameters in a rat model of D-galactose (DGL) -induced liver and kidney injury[5].
    Ceftriaxone sodium salt (200, 400 mg/kg, Intraperitoneal injection) has a protective effect on convulsion induced by Pentylenetetrazol (PTZ) and PTZ-related oxidative damage in rats[6].
    Ceftriaxone sodium salt (100, 200 mg/kg, Intraperitoneal injection) reduces mechanical dysodynia and hyperalgesia by activating GLT-1 in streptozotocin (HY-13753)-induced diabetic rat models[7].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: DGL-induced rat model[5]
    Dosage: 200 mg/kg
    Administration: i.p.
    Result: Reduced the BUN、Cr 、AST and ALT levels.
    Attenuated the MDA levels and enhanced GPx and CAT activities.
    Reduced the levels of IL-1β and TNF-α mRNA.
    Animal Model: PTZ-induced rat model[6]
    Dosage: 200, 400 mg/kg
    Administration: i.p. 60 min before to PTZ (70 mg/kg)
    Result: Both of the two ceftriaxone groups had lower spike percentages than the saline group.
    Significantly lower MDA levels and higher SOD activity in 200 and 400 mg/kg.
    Molecular Weight

    598.54

    Formula

    C18H16N8Na2O7S3
    CAS No.
    Appearance

    Solid

    Color

    White to off-white

    SMILES

    O=C(O[Na])C(N12)=C(CSC(N(C)N=C3O[Na])=NC3=O)CS[C@]2([H])[C@H](NC(/C(C4=CSC(N)=N4)=N\OC)=O)C1=O
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    4°C, sealed storage, away from moisture and light

    *In solvent : -80°C, 1 year; -20°C, 6 months (sealed storage, away from moisture and light)

    Solvent & Solubility
    In Vitro: 

    DMSO : 50 mg/mL (83.54 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    H2O : ≥ 40 mg/mL (66.83 mM)

    *"≥" means soluble, but saturation unknown.

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 1.6707 mL 8.3537 mL 16.7073 mL
    5 mM 0.3341 mL 1.6707 mL 3.3415 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months (sealed storage, away from moisture and light). When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

    • Molarity Calculator

    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    Mass
    =
    Concentration
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    Volume
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    Molecular Weight *

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start)

    C1

    ×
    Volume (start)

    V1

    =
    Concentration (final)

    C2

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    Volume (final)

    V2

    In Vivo:

    Select the appropriate dissolution method based on your experimental animal and administration route.

    For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
    To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

      Solubility: ≥ 2.5 mg/mL (4.18 mM); Clear solution

      This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

      Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
    • Protocol 2

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

      Solubility: ≥ 2.5 mg/mL (4.18 mM); Clear solution

      This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

      Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.

    For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  PBS

      Solubility: 100 mg/mL (167.07 mM); Clear solution; Need ultrasonic

    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

    mg/kg

    Animal weight
    (per animal)

    g

    Dosing volume
    (per animal)

    μL

    Number of animals

    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Calculation results:
    Working solution concentration: mg/mL
    This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
    Purity & Documentation

    Purity: 99.90%

    SDS (396 KB)

    COA (254 KB) HNMR (298 KB) RP-HPLC (205 KB) LCMS (94 KB)

    Handling Instructions (2659 KB)
    References

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months (sealed storage, away from moisture and light). When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    H2O / DMSO 1 mM 1.6707 mL 8.3537 mL 16.7073 mL 41.7683 mL
    5 mM 0.3341 mL 1.6707 mL 3.3415 mL 8.3537 mL
    10 mM 0.1671 mL 0.8354 mL 1.6707 mL 4.1768 mL
    15 mM 0.1114 mL 0.5569 mL 1.1138 mL 2.7846 mL
    20 mM 0.0835 mL 0.4177 mL 0.8354 mL 2.0884 mL
    25 mM 0.0668 mL 0.3341 mL 0.6683 mL 1.6707 mL
    30 mM 0.0557 mL 0.2785 mL 0.5569 mL 1.3923 mL
    40 mM 0.0418 mL 0.2088 mL 0.4177 mL 1.0442 mL
    50 mM 0.0334 mL 0.1671 mL 0.3341 mL 0.8354 mL
    60 mM 0.0278 mL 0.1392 mL 0.2785 mL 0.6961 mL
    DMSO 80 mM 0.0209 mL 0.1044 mL 0.2088 mL 0.5221 mL

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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    Ceftriaxone sodium salt Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Ceftriaxone74578-69-1Ro 13-9904AntibioticGSK-3BacterialAurora KinaseGlycogen synthase kinase-3Glycogen synthase kinase 3GSK3βAurora BAstrocyteA549DGL-induced rat modelPTZ-induced rat modelantibacterialInhibitorinhibitorinhibit

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