2. Disease Areas
  3. Neurological, Eye or Ear Disease
  4. CNS Infection
  5. Meningitis

Meningitis

Meningitis is an inflammation of the meninges, the protective membranes covering the brain and spinal cord, which can result from viral, bacterial, fungal, parasitic infections, or non-infectious causes such as injuries, cancer, or drugs. Common symptoms include fever, severe headache, nausea, vomiting, stiff neck, and photophobia; in infants, signs may include irritability, vomiting, and a bulging fontanelle. Bacterial meningitis is a life-threatening condition requiring urgent antibiotic treatment. Complications can include stroke, hearing loss, and brain damage. Diagnosis relies on blood tests, imaging, and lumbar puncture. Vaccines are available to prevent certain bacterial forms of meningitis.

References:

Meningitis (3):

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-P2866
    β-N-Acetylhexosaminidase, Streptococcus pneumoniae 9012-33-3
    β-N-Acetylhexosaminidase, Streptococcus pneumoniae is a cell surface virulence factor of Streptococcus pneumoniae, which contains two synergistically acting GH20 domains (with higher activity in GH20-2). β-N-Acetylhexosaminidase, Streptococcus pneumoniae specifically recognizes and hydrolyzes substrates with β(1,2) glycosidic bonds via Trp-443 and Tyr-482 residues. β-N-Acetylhexosaminidase, Streptococcus pneumoniae catalyzes the hydrolysis of β(1,2)-linked N-acetylglucosamine groups and related disaccharides, and promotes persistent colonization of bacteria in the airway by modifying host defense molecules and releasing monosaccharides for bacterial growth. β-N-Acetylhexosaminidase, Streptococcus pneumoniae can be used in studies related to Streptococcus pneumoniae infection, acute pneumonia, otitis media and meningitis.
    β-N-Acetylhexosaminidase, Streptococcus pneumoniae
  • HY-B0368B
    D-Captopril 119238-52-7
    D-Captopril is a NDM-1 inhibitor and a competitive BlaB inhibitor, with an IC50 value of 21.8 µM against NDM-1 and a Ki of 70-100 µM against BlaB. D-Captopril synergistically reduces the minimum inhibitory concentration of Meropenem (HY-13678) against NDM-1-expressing bacteria. D-Captopril binds to BcII via its thiolate sulfur atom and carboxylate group, altering metal ion occupancy and modulating Cd2+ binding affinity. D-Captopril can be used in the research of neonatal meningitis, sepsis and bacterial infections.
    D-Captopril
  • HY-179704
    Antifungal agent 141
    Antifungal agent 141, a Phenoxazine (HY-34463) derivative, is an antifungal agent. Antifungal agent shows potent antifungal activity in Cryptococcus neoformans and Candida albicans with MIC values of 2 and 4 µg/mL. Antifungal agent 141 can be used for the research of cryptococcal meningitis.
    Antifungal agent 141