2. Anti-infection
  3. Beta-lactamase Antibiotic Bacterial
  4. D-Captopril

D-Captopril is a NDM-1 inhibitor and a competitive BlaB inhibitor, with an IC50 value of 21.8 µM against NDM-1 and a Ki of 70-100 µM against BlaB. D-Captopril synergistically reduces the minimum inhibitory concentration of Meropenem (HY-13678) against NDM-1-expressing bacteria. D-Captopril binds to BcII via its thiolate sulfur atom and carboxylate group, altering metal ion occupancy and modulating Cd2+ binding affinity. D-Captopril can be used in the research of neonatal meningitis, sepsis and bacterial infections.

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D-Captopril

D-Captopril Chemical Structure

CAS No. : 119238-52-7

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D-Captopril Related Antibodies

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Description

D-Captopril is a NDM-1 inhibitor and a competitive BlaB inhibitor, with an IC50 value of 21.8 µM against NDM-1 and a Ki of 70-100 µM against BlaB. D-Captopril synergistically reduces the minimum inhibitory concentration of Meropenem (HY-13678) against NDM-1-expressing bacteria. D-Captopril binds to BcII via its thiolate sulfur atom and carboxylate group, altering metal ion occupancy and modulating Cd2+ binding affinity. D-Captopril can be used in the research of neonatal meningitis, sepsis and bacterial infections[1][2][3].

IC50 & Target[2]

NDM-1

21.8 μM (IC50)

In Vitro

D-Captopril (2 mM; ~5 weeks) binds to BlaB of *Chryseobacterium meningosepticum* by inserting its sulfhydryl group between the two active-site Zn2+ ions of BlaB and displacing the catalytic hydroxyl group. It acts as a competitive inhibitor of BlaB at neutral pH, with a Ki of 70-100 μM[1].
D-Captopril inhibits the enzymatic activity of purified wild-type NDM-1 through interactions with active site residues and stabilized water networks, with an IC50 value of 21.8 μM[2].
D-Captopril (8-32 mg/L) acts synergistically with Meropenem (HY-13678) at the concentration of 32 mg/L, reducing the MIC of Meropenem against E. coli DH5α expressing NDM-1 from 8 mg/L to 4 mg/L, whereas no synergistic effect is observed at the concentration of 8 mg/L[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

D-Captopril Related Antibodies
Molecular Weight

217.29

Formula

C9H15NO3S
CAS No.
SMILES

SC[C@@H](C)C(N1[C@H](CCC1)C(O)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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D-Captopril Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

D-Captopril119238-52-7Beta-lactamaseAntibioticBacterialβ-lactamasemeropenemangiotensin-converting enzymemetallo-β-lactamaseBcIIBlaBNDM-1CphAE. coli DH5αbradykininZn2+Inhibitorinhibitorinhibit

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