Ceftriaxone sodium hydrate
Based on 19 publication(s) in Google Scholar
Ceftriaxone sodium hydrate (Ro 13-9904 sodium hydrate) is a broad spectrum β-lactam third-generation cephalosporin antibiotic, which has good antibacterial activity against a variety of gram-negative and positive bacteria. Ceftriaxone sodium hydrate is a covalent inhibitor of GSK3β with IC50 value of 0.78 μM. Ceftriaxone sodium hydrate is an inhibitor of Aurora B. Ceftriaxone sodium hydrate has anti-inflammatory, antitumor and antioxidant activities. Ceftriaxone sodium hydrate can be used in the study of bacterial infections and meningitis.
For research use only. We do not sell to patients.
- Purity: 99.47%
- CAS No.: 104376-79-6
- Formula: C18H23N8Na2O10.5S3
- Molecular Weight:661.60
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Storage:
4°C, stored under nitrogen, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Ceftriaxone sodium hydrate
More- Signal Transduct Target Ther. 2025 Dec 15;10(1):406. [Abstract]
- Nat Commun. 2022 Mar 2;13(1):1116. [Abstract]
- Sci Adv. 2025 Dec 5;11(49):eadw7972. [Abstract]
- EBioMedicine. 2022 Apr;78:103943. [Abstract]
- Proc Natl Acad Sci U S A. 2025 Dec 2;122(48):e2524436122. [Abstract]
- Cell Chem Biol. 2024 May 20:S2451-9456(24)00179-X. [Abstract]
- Food Res Int. 2026 Aug 31:238:119421. [Abstract]
- J Environ Chem Eng. 2026 Apr 16;14(3):122734.
- Emerg Microbes Infect. 2024 Dec;13(1):2321981. [Abstract]
- BMC Microbiol. 2025 Apr 29;25(1):257. [Abstract]
- FASEB J. 2026 Jan 31;40(2):e71438. [Abstract]
- Antimicrob Agents Chemother. 2026 Apr;70(4):e0170625. [Abstract]
- Microbiol Spectr. 2025 Oct 16:e0160325. [Abstract]
- BMC Cancer. 2025 Jun 1;25(1):977. [Abstract]
- AMB Express. 2024 Dec 24;14(1):141. [Abstract]
- Infect Drug Resist. 2026 May 8;19.
- Rapid Commun Mass Spectrom. 2026 May 30;40(10):e70053. [Abstract]
- Diagn Microbiol Infect Dis. 2026 Feb;114(2):117181. [Abstract]
- Chemosphere. 2023 Dec:344:140353. [Abstract]
Customer Validation & Images
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Microbiological Assay
All Antibiotic Isoforms
MoreAll Aurora Kinase Isoforms
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Biological Activity
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β-lactam |
Ceftriaxone sodium hydrate (100 μM, 24 h) protects MPP+ treated astrocytes by inhibiting the NF-κB/JNK/c-Jun signaling pathway [3].
Ceftriaxone sodium hydrate (500 μM, 24-48 h) effectively inhibits unanchored cell growth in A549, H520 and H1650 lung cancer cells by inhibiting Aurora B[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Astrocyte
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Concentration:100 μM
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Incubation Time:24 h
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Result:Improved cell viability and increased glutamate uptake after MPP+ expose.
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Cell Line:Astrocyte
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Concentration:100 μM
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Incubation Time:24 h
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Result:Enhanced GLT-1 and GFAP expression. Decreased the expression of p-p50、p-IKKα、p-Relb. Decreased the number of TUNEL-positive cells.
Ceftriaxone sodium hydrate (200, 400 mg/kg, Intraperitoneal injection) has a protective effect on convulsion induced by Pentylenetetrazol (PTZ) and PTZ-related oxidative damage in rats[6].
Ceftriaxone sodium hydrate (100, 200 mg/kg, Intraperitoneal injection) reduces mechanical dysodynia and hyperalgesia by activating GLT-1 in Streptozocin (HY-13753)-induced diabetic rat models[7].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:DGL-induced rat model[5]
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Dosage:200 mg/kg
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Administration:i.p.
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Result:Reduced the BUN、Cr 、AST and ALT levels. Attenuated the MDA levels and enhanced GPx and CAT activities. Reduced the levels of IL-1β and TNF-α mRNA.
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Animal Model:PTZ-induced rat model[6]
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Dosage:200, 400 mg/kg
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Administration:i.p. 60 min before to PTZ (70 mg/kg)
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Result:Both of the two ceftriaxone groups had lower spike percentages than the saline group. Significantly lower MDA levels and higher SOD activity in 200 and 400 mg/kg.
Chemical Information
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CAS No. 104376-79-6
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Appearance Solid
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Molecular Weight 661.60
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Formula C18H23N8Na2O10.5S3
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Color White to off-white
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SMILES
O=C(O[Na])C(N12)=C(CSC(N(C)N=C3O[Na])=NC3=O)CS[C@]2([H])[C@H](NC(/C(C4=CSC(N)=N4)=N\OC)=O)C1=O.[3.5H2O]
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Synonyms
Ro 13-9904 sodium hydrate
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, stored under nitrogen, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture)
Publications (19)
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Journal Impact Factor
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Most Recent
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Signal Transduct Target Ther
Selective depletion of tumor-associated SAMHD1 enhances chemotherapeutic efficacy and antitumor immune responses. [Abstract]2025 Dec 15;10(1):406. PMID: 41392286 -
Nat Commun
Antimicrobial resistance and population genomics of multidrug-resistant Escherichia coli in pig farms in mainland China. [Abstract]2022 Mar 2;13(1):1116. PMID: 35236849 -
Sci Adv
EphB1-NR2B receptor signaling in glutamatergic neurons of the ventroposteromedial thalamic nucleus regulates emergence from anesthesia. [Abstract]2025 Dec 5;11(49):eadw7972. PMID: 41348875 -
EBioMedicine
A novel inhibitor of monooxygenase reversed the activity of tetracyclines against tet(X3)/tet(X4)-positive bacteria. [Abstract]2022 Apr;78:103943. PMID: 35306337 -
Proc Natl Acad Sci U S A
Antibiotics accumulate in Klebsiella pneumoniae liver abscesses but fail to eliminate antibiotic-tolerant populations. [Abstract]2025 Dec 2;122(48):e2524436122. PMID: 41296732 -
Cell Chem Biol
AspSnFR: A genetically encoded biosensor for real-time monitoring of aspartate in live cells. [Abstract]2024 May 20:S2451-9456(24)00179-X. PMID: 38806058 -
Food Res Int
Prevalence, plasmid transmission, and chromosomal integration of blaCTX-M genes in Salmonella isolated from retail chicken and pork meats in China. [Abstract]2026 Aug 31:238:119421. PMID: 42215089 -
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Emerg Microbes Infect
AMXT-1501 targets membrane phospholipids against Gram-positive and -negative multidrug-resistant bacteria. [Abstract]2024 Dec;13(1):2321981. PMID: 38422452 -
BMC Microbiol
Klebsiella pneumoniae under xylose pressure: the growth adaptation, antimicrobial susceptibility, global proteomics analysis and role of XylA and XylB proteins. [Abstract]2025 Apr 29;25(1):257. PMID: 40301709 -
FASEB J
Enhancing the Susceptibility of Methicillin-Resistant Staphylococcus aureus to β-Lactam Antibiotics Through the Use of 4-Methoxysalicyl Aldehyde. [Abstract]2026 Jan 31;40(2):e71438. PMID: 41524623 -
Antimicrob Agents Chemother
Stepwise evolution and clonal enrichment of gepotidacin resistance in Neisseria gonorrhoeae. [Abstract]2026 Apr;70(4):e0170625. PMID: 41810969 -
Microbiol Spectr
The adaptive growth and mechanisms of Klebsiella pneumoniae under sucrose and glucose exposure. [Abstract]2025 Oct 16:e0160325. PMID: 41099518 -
BMC Cancer
Cholesterol-induced colorectal cancer progression and its mitigation through gut microbiota remodeling and simvastatin treatment. [Abstract]2025 Jun 1;25(1):977. PMID: 40452015 -
AMB Express
Repurposing pinaverium bromide against Staphylococcus and its biofilms with new mechanisms. [Abstract]2024 Dec 24;14(1):141. PMID: 39718732
Ceftriaxone sodium hydrate purchased from MedChemExpress. Usage Cited in: AMB Express. 2024 Dec 24;14(1):141. [Abstract]
Combinational antimicrobial effects between PVB and conventional antibiotics against MRSA ATCC 43,300. TET, Tetracycline. DOX, Doxycycline. E, Erythromycin. AZI, Azithromycin. P, Penicillin. CAZ, Ceftazidime. AMP, Ampicillin. CEZ, Cefazolin. CEF, Cefotaxime. OXA, Oxacillin. CRO, Ceftriaxone. AMK, Amikacin. GEN, Gentamycin, KANA, Kanamycin. TOB, Tobramycin. SPC, Spectinomycin.
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Rapid Commun Mass Spectrom
Sensitive Detection of Salmonella Susceptibility to Ceftriaxone and Azithromycin Using Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry. [Abstract]2026 May 30;40(10):e70053. PMID: 41704149 -
Diagn Microbiol Infect Dis
2026 Feb;114(2):117181. PMID: 41205476 -
Chemosphere
Sustainable production of Fe-doped MnO2 nanoparticles for accelerated tetracycline antibiotic detoxification. [Abstract]2023 Dec:344:140353. PMID: 37797898
Solvent & Solubility
DMSO : 100 mg/mL (151.15 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (284 KB)
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SDS (558 KB)
- English - EN (558 KB)
- Français - FR (558 KB)
- Deutsch - DE (558 KB)
- Norwegian - NO (558 KB)
- Español - ES (558 KB)
- Swedish - SV (558 KB)
- Italian - IT (558 KB)
- Korean - KR (558 KB)
- Portuguese - PT (558 KB)
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Handling Instructions (2659 KB)
References
[1]. Nahata MC, et al. Ceftriaxone: a third-generation cephalosporin. Drug Intell Clin Pharm. 1985 Dec;19(12):900-6. [Content Brief]
[2]. Nassar H, et al. Molecular docking, molecular dynamics simulations and in vitro screening reveal cefixime and ceftriaxone as GSK3β covalent inhibitors. RSC Adv. 2023 Apr 11;13(17):11278-11290. [Content Brief]
[3]. Zhang Y, et al. Ceftriaxone Protects Astrocytes from MPP(+) via Suppression of NF-κB/JNK/c-Jun Signaling. Mol Neurobiol. 2015 Aug;52(1):78-92. [Content Brief]
[4]. Li X, et al. Ceftriaxone, an FDA-approved cephalosporin antibiotic, suppresses lung cancer growth by targeting Aurora B. Carcinogenesis. 2012 Dec;33(12):2548-57. [Content Brief]
[5]. Hakimizadeh E, et al. Ceftriaxone improves hepatorenal damages in mice subjected to D-galactose-induced aging. Life Sci. 2020 Oct 1;258:118119. [Content Brief]
[6]. Uyanikgil Y, et al. Positive effects of ceftriaxone on pentylenetetrazol-induced convulsion model in rats. Int J Neurosci. 2016;126(1):70-5. [Content Brief]
[7]. Gunduz O, et al. Anti-allodynic and anti-hyperalgesic effects of ceftriaxone in streptozocin-induced diabetic rats. Neurosci Lett. 2011 Mar 10;491(1):23-5. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 1.5115 mL | 7.5574 mL | 15.1149 mL | 37.7872 mL |
| 5 mM | 0.3023 mL | 1.5115 mL | 3.0230 mL | 7.5574 mL | |
| 10 mM | 0.1511 mL | 0.7557 mL | 1.5115 mL | 3.7787 mL | |
| 15 mM | 0.1008 mL | 0.5038 mL | 1.0077 mL | 2.5191 mL | |
| 20 mM | 0.0756 mL | 0.3779 mL | 0.7557 mL | 1.8894 mL | |
| 25 mM | 0.0605 mL | 0.3023 mL | 0.6046 mL | 1.5115 mL | |
| 30 mM | 0.0504 mL | 0.2519 mL | 0.5038 mL | 1.2596 mL | |
| 40 mM | 0.0378 mL | 0.1889 mL | 0.3779 mL | 0.9447 mL | |
| 50 mM | 0.0302 mL | 0.1511 mL | 0.3023 mL | 0.7557 mL | |
| 60 mM | 0.0252 mL | 0.1260 mL | 0.2519 mL | 0.6298 mL | |
| 80 mM | 0.0189 mL | 0.0945 mL | 0.1889 mL | 0.4723 mL | |
| 100 mM | 0.0151 mL | 0.0756 mL | 0.1511 mL | 0.3779 mL |
Ceftriaxone sodium hydrate Related Classifications
HY-B0712A Related Classifications
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