Cholest-5-ene-3ß,22(S)-diol
Based on 1 Customer Validation
Cholest-5-ene-3ß,22(S)-diol ((22S)-Hydroxycholesterol) is an orally active oxysterol with no significant cytotoxic, oxidative, or inflammatory effects on human prokaryotic leukemia cells. Cholest-5-ene-3ß,22(S)-diol inhibits weight gain and increased serum triacylglycerol (TAG) levels in rat models.
For research use only. We do not sell to patients.
- Purity: 98.69%
- CAS No.: 22348-64-7
- Formula: C27H46O2
- Molecular Weight:402.65
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HEK293 | EC50 |
2.9 μM
Compound: 14
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Binding affinity to FLAG/tGFP-tagged NPC1 I1061T mutant (unknown origin) expressed in HEK293 cells assessed as localization after 24 hrs by fluorescence microscopy
Binding affinity to FLAG/tGFP-tagged NPC1 I1061T mutant (unknown origin) expressed in HEK293 cells assessed as localization after 24 hrs by fluorescence microscopy
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[PMID: 24928400] |
Cholest-5-ene-3ß,22(S)-diol (10 μg/mL, 20 μg/mL; 24 h) shows no effect on phosphatidylserine externalization, mitochondrial transmembrane potential, cellular permeability to propidium iodide, and morphological nuclear changes in U937 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Pharmacokinetic Analysis in Rats[2]
| Route | Dose (mg/kg) | Cmax (ng/mL) | Tmax (h) | AUCt (ng·h/mL) | AUC (ng·h/mL) | T1/2 (h) | Extent of tritium exchange (%) |
| i.v. | 50 | 22.4 | 0.08 | 174 | 195 | 8.1 | 2.8 |
| p.o. | 50 | 7.5 | 4 | 95.2 | 104 | 6.4 | 1.2 |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male rats injected with Pentobarbital (20 mg, 50 mg/mL; i.p.)[2]
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Dosage:30 mg/kg/day
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Administration:Oral gavage; 3 weeks consecutively
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Result:Decreased body weight gain significantly after 1 week treatment.
Increased gene expression of Ucp3 and Cpt2 in liver and skeletal muscle, and increased protein level of Ucp3 in skeletal muscle after 3 weeks treatment.
Chemical Information
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CAS No. 22348-64-7
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Appearance Solid
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Molecular Weight 402.65
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Formula C27H46O2
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Color White to off-white
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SMILES
C[C@]12[C@](CC[C@]1([H])[C@H](C)[C@@H](O)CCC(C)C)([H])[C@@](CC=C3C[C@H]4O)([H])[C@@](CC2)([H])[C@]3(CC4)C
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Synonyms
(22S)-Hydroxycholesterol
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Purity & Documentation
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Data Sheet (272 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Lemaire-Ewing S, et al. Comparison of the cytotoxic, pro-oxidant and pro-inflammatory characteristics of different oxysterols. Cell Biol Toxicol. 2005 Mar;21(2):97-114. [Content Brief]
[2]. Tranheim Kase E, et al. Dietary supplementation with 22-S-hydroxycholesterol to rats reduces body weight gain and the accumulation of liver triacylglycerol. Lipids. 2012 May;47(5):483-93. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Cholest-5-ene-3ß,22(S)-diol Related Classifications
HY-137307 Related Classifications
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