1. Metabolic Enzyme/Protease
  2. LXR
  3. GSK2033

GSK2033 

Cat. No.: HY-108688 Purity: 99.37%
Handling Instructions

GSK2033 is a LXR antagonist with pIC50s of 7 and 7.4 for LXRα or LXRβ, respectively.

For research use only. We do not sell to patients.

GSK2033 Chemical Structure

GSK2033 Chemical Structure

CAS No. : 1221277-90-2

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10 mM * 1 mL in DMSO USD 156 In-stock
Estimated Time of Arrival: December 31
5 mg USD 120 In-stock
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10 mg USD 216 In-stock
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25 mg USD 456 In-stock
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50 mg USD 756 In-stock
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100 mg USD 1320 In-stock
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Customer Review

Based on 3 publication(s) in Google Scholar

Top Publications Citing Use of Products
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Description

GSK2033 is a LXR antagonist with pIC50s of 7 and 7.4 for LXRα or LXRβ, respectively.

IC50 & Target

pIC50: 7 (LXRα), 7.4 (LXRβ)[1]

In Vitro

GSK2033 is a LXR antagonist with pIC50s of 7 and 7.4 for LXRα or LXRβ, respectively. GSK2033 dose-dependently suppresses basal transcription in full-length LXRα or full-length LXRβ cotransfection assays with IC50s of 17 nM and 9 nM, respectively. GSK2033 also effectively suppresses the transcription of an ABCA1 driven luciferase reporter dose-dependently displaying IC50s of 52 nM for LXRα and 10 nM for LXRβ. GSK2033 also suppresses the expression of both of fatty acid synthase (FASN) and SREBP1[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

One month treatment of GSK2033 does not have significant effects on hepatic triglyceride levels. Plasma triglyceride levels are also unaffected by treatment with GSK2033[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

591.66

Formula

C₂₉H₂₈F₃NO₅S₂

CAS No.

1221277-90-2

SMILES

O=S(C1=C(C)C=C(C)C=C1C)(N(CC2=CC=C(C3=CC=CC(S(=O)(C)=O)=C3)C=C2)CC4=CC=C(C(F)(F)F)O4)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 30 mg/mL (50.70 mM; Need ultrasonic and warming)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.6902 mL 8.4508 mL 16.9016 mL
5 mM 0.3380 mL 1.6902 mL 3.3803 mL
10 mM 0.1690 mL 0.8451 mL 1.6902 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Cell Assay
[2]

HepG2 cells are maintained in minimal essential medium supplemented with 10% FBS and antibiotics. HepG2 cells are then treated for 24 h with GSK2033 followed by assessment of expression of genes by qPCR[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Administration
[2]

21-week old male C57BL6 DIO mice are used. Animals are individually housed and fed a high fat diet (60% kcal/fat diet, 20% carbohydrate) for the duration of the experiment that includes GSK2033 administration for 28 days (30 mg/kg, q. d, i. p.). Body weight and food intake are monitored daily[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
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Keywords:

GSK2033GSK 2033GSK-2033LXRLiver X receptorInhibitorinhibitorinhibit

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GSK2033
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