22348-64-7
Chemical Structure
Cholest-5-ene-3ß,22(S)-diol
Synonym(s): (22S)-Hydroxycholesterol
- CAS No.: 22348-64-7
- Formula:C27H46O2
- Molecular Weight:402.65
IUPAC Name: (3S,8S,9S,10R,13S,14S,17R)-17-((2S,3S)-3-hydroxy-6-methylheptan-2-yl)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-ol
InChIKey: RZPAXNJLEKLXNO-QUOSNDFLSA-N
SMILES: C[C@]12[C@](CC[C@]1([H])[C@H](C)[C@@H](O)CCC(C)C)([H])[C@@](CC=C3C[C@H]4O)([H])[C@@](CC2)([H])[C@]3(CC4)C
Biological Activity: Cholest-5-ene-3ß,22(S)-diol ((22S)-Hydroxycholesterol) is an orally active oxysterol with no significant cytotoxic, oxidative, or inflammatory effects on human prokaryotic leukemia cells. Cholest-5-ene-3ß,22(S)-diol inhibits weight gain and increased serum triacylglycerol (TAG) levels in rat models[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Cholest-5-ene-3ß,22(S)-diol | 98.69% | Cholest-5-ene-3ß,22(S)-diol ((22S)-Hydroxycholesterol) is an orally active oxysterol with no significant cytotoxic, oxidative, or inflammatory effects on human prokaryotic leukemia cells. Cholest-5-ene-3ß,22(S)-diol inhibits weight gain and increased serum triacylglycerol (TAG) levels in rat models. | ||||||||||||||||||||
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Cholest-5-ene-3ß,22(S)-diol-d7 | Cholest-5-ene-3ß,22(S)-diol-d7 is deuterium labeled Cholest-5-ene-3ß,22(S)-diol. | |||||||||||||||||||||
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- [1]. Lemaire-Ewing S, et al. Comparison of the cytotoxic, pro-oxidant and pro-inflammatory characteristics of different oxysterols. Cell Biol Toxicol. 2005 Mar;21(2):97-114. [Content Brief]
- [2]. Tranheim Kase E, et al. Dietary supplementation with 22-S-hydroxycholesterol to rats reduces body weight gain and the accumulation of liver triacylglycerol. Lipids. 2012 May;47(5):483-93. [Content Brief]
