1. Epigenetics
    TGF-beta/Smad
    Apoptosis
    GPCR/G Protein
    Immunology/Inflammation
  2. PKC
    Apoptosis
    CXCR
  3. Decursin

Decursin  (Synonyms: (+)-Decursin)

Cat. No.: HY-18981 Purity: 99.94%
COA Handling Instructions

Decursin ((+)-Decursin) is a potent anti-tumor agent. Decursin also is a cytotoxic agent and a potent protein kinase C activator. Decursin induces apoptosis and cell cycle arrest at G1 phase. Decursin decreases the expression of CDK2, CDK4, CDK6, cyclin D1 protein at 48 h. Decursin inhibits cell proliferation and migration. Decursin shows anti-tumor, anti-inflammatory and analgesic activities.

For research use only. We do not sell to patients.

Decursin Chemical Structure

Decursin Chemical Structure

CAS No. : 5928-25-6

Size Price Stock Quantity
Solution
10 mM * 1 mL in DMSO USD 110 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 110 In-stock
Estimated Time of Arrival: December 31
Solid
5 mg USD 100 In-stock
Estimated Time of Arrival: December 31
10 mg USD 150 In-stock
Estimated Time of Arrival: December 31
25 mg USD 330 In-stock
Estimated Time of Arrival: December 31
50 mg USD 590 In-stock
Estimated Time of Arrival: December 31
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200 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Decursin

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Decursin ((+)-Decursin) is a potent anti-tumor agent. Decursin also is a cytotoxic agent and a potent protein kinase C activator. Decursin induces apoptosis and cell cycle arrest at G1 phase. Decursin decreases the expression of CDK2, CDK4, CDK6, cyclin D1 protein at 48 h. Decursin inhibits cell proliferation and migration. Decursin shows anti-tumor, anti-inflammatory and analgesic activities[1][2][3][4].

In Vitro

Decursin (0, 25, 50, 100 µM; 24, 28, 72, 96 h) inhibits cell growth in a dose- and time- dependent manner in DU145 cells[1].
Decursin (0, 25, 50, 100 µM; 24, 28, 72, 96 h) induces apoptosis and cell cycle arrest at G1 phase in DU145 cells, G1, S as well as G2-M arrests in PC-3 cells[1].
Decursin (0, 25, 50, 100 µM; 24, 48 h) decreases the expression of CDK2, CDK4, CDK6, cyclin D1 protein at 48 h in DU145 cells[1].
Decursin (0, 5, 20, 100 µM; 7 days) inhibits the proliferation and differentiation ability of AC133+ cells[2].
Decursin (0, 5, 20, 100 µM) inhibits SDF-1a-induced activation of Akt, ERK1/2, and eNOS in a dose-dependent manner[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: DU145 cells
Concentration: 0, 25, 50, 100 µM
Incubation Time: 24, 28, 72, 96 h
Result: Showed a dose- and time- dependent inhibition cell growth with 22% to 51%, 21%to 68%, 9% to 72%, 42% to 90% growth inhibition after 24, 48, 72, and 96 hours oftreatment, respectively. And caused 15%-45% cell death.

Cell Cycle Analysis[1]

Cell Line: DU145 cells
Concentration: 0, 25, 50, 100 µM
Incubation Time: 12-96 h
Result: Caused 52%, 65%, and 78% DU145 cells in G1phase.

Western Blot Analysis[1]

Cell Line: DU145 cells
Concentration: 0, 25, 50, 100 µM
Incubation Time: 24, 48 h
Result: Did not show any any alteration inprotein levels of CDK2, CDK4, CDK6, cyclin D1, and cyclin E, but dose-dependent decreased in the expression of these proteins except cyclin E at 48 h.
In Vivo

Decursin (4 mg/kg; s.c.; daily for 4 weeks) shows anti-tumor activity in mouse[2].
Decursin (50 mg/kg; intrathecal injection; three times at 2-day intervals, for 6 days) shows analgesic ability in paclitaxel-induced peripheral neuropathy in mouse[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6J mice (LLC cells)[2]
Dosage: 4 mg/kg
Administration: S.c.; daily for 4 weeks
Result: Delayed tumor formation and dramatically decreased tumor growth by inhibition of angiogenesis through VEGFR-2 signaling pathway.
Animal Model: Eight-week-old adult C57BL/6J male and female mice[3]
Dosage: 50 mg/kg
Administration: Intrathecal injection; three times at 2-day intervals, for 6 days
Result: Demonstrated the analgesic ability in the in vivo model of paclitaxel-induced peripheral neuropathy.
Molecular Weight

328.36

Formula

C19H20O5

CAS No.
SMILES

C/C(C)=C\C(O[[email protected]](C(C)(C)O1)CC2=C1C=C(O3)C(C=CC3=O)=C2)=O

Structure Classification
Source
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (152.27 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.0454 mL 15.2272 mL 30.4544 mL
5 mM 0.6091 mL 3.0454 mL 6.0909 mL
10 mM 0.3045 mL 1.5227 mL 3.0454 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (7.61 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (7.61 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (7.61 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation

Purity: 99.94%

References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Decursin
Cat. No.:
HY-18981
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