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Decursin (Synonyms: (+)-Decursin)

Cat. No.: HY-18981 Purity: 99.98%
Handling Instructions

Decursin is an anticancer agent, with potential anti-inflammatory activity.

For research use only. We do not sell to patients.

Decursin Chemical Structure

Decursin Chemical Structure

CAS No. : 5928-25-6

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 110 In-stock
Estimated Time of Arrival: December 31
5 mg USD 100 In-stock
Estimated Time of Arrival: December 31
10 mg USD 150 In-stock
Estimated Time of Arrival: December 31
25 mg USD 330 In-stock
Estimated Time of Arrival: December 31
50 mg USD 590 In-stock
Estimated Time of Arrival: December 31
100 mg   Get quote  
200 mg   Get quote  

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Customer Review

  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

  • References

Description

Decursin is an anticancer agent, with potential anti-inflammatory activity.

In Vitro

Decursin (25-100 μM) shows a strong dose- and time-dependent inhibition of cell growth, accounting for 22% to 51%, 21% to 68%, 9% to 72%, and 42% to 90% growth inhibition after 24, 48, 72, and 96 hours of treatment, respectively. Furthermore, it is observed that both Decursin and Decursinol have cytotoxic effect on DU145 cells, in which similar treatment (25-100 μM for 24, 48, 72, and 96 hours) with Decursin cause 15% to 45% cell death versus 11% to 12% in controls[1]. Decursin blocks tumor progression by suppression of angiopoietin-2, angiopoietin receptor Tie-2, and endothelial nitric oxide synthase (eNOS) in endothelial progenitor cells. Decursin has the ability to inhibit vascular endothelial growth factor (VEGF)-induced proliferation, metastasis, and tube formation in human umbilical vein endothelial cells (HUVECs). Decursin inhibits pro-inflammatory molecules, such as chemokines, cytokines, and enzymes such as Cyclooxygenase-2 (COX-2) and MMPs[2].

Solvent & Solubility
In Vitro: 

10 mM in DMSO

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.0454 mL 15.2272 mL 30.4544 mL
5 mM 0.6091 mL 3.0454 mL 6.0909 mL
10 mM 0.3045 mL 1.5227 mL 3.0454 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Cell Assay
[1]

To assess the biological activity of these compounds in terms of cell growth and death, DU145 cells are treated with 25, 50, and 100 μM doses of Decursin and Decursinol for 24, 48, 72, and 96 hours[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
Molecular Weight

328.36

Formula

C₁₉H₂₀O₅

CAS No.

5928-25-6

SMILES

C/C(C)=C\C(O[[email protected]](C(C)(C)O1)CC2=C1C=C(O3)C(C=CC3=O)=C2)=O

Storage

4°C, protect from light

Shipping

Room temperature in continental US; may vary elsewhere

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Product Name:
Decursin
Cat. No.:
HY-18981
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Decursin

Cat. No.: HY-18981