1. Immunology/Inflammation
  2. COX
  3. Naproxcinod

Naproxcinod  (Synonyms: AZD 3582; HCT 3012; Nitronaproxen)

Cat. No.: HY-14931
Handling Instructions

Naproxcinod (Nitronaproxen) is the first in class of cyclooxygenase (COX)-inhibiting nitric oxide donators (CINODs). Naproxcinod shows analgesic and anti-inflammatory effects, it can be used for the research of osteoarthritis and inflammation.

For research use only. We do not sell to patients.

Naproxcinod Chemical Structure

Naproxcinod Chemical Structure

CAS No. : 163133-43-5

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Description

Naproxcinod (Nitronaproxen) is the first in class of cyclooxygenase (COX)-inhibiting nitric oxide donators (CINODs). Naproxcinod shows analgesic and anti-inflammatory effects, it can be used for the research of osteoarthritis and inflammation[1][2][3].

In Vitro

Naproxcinod (1-30 μM; 15 min) concentration-dependently increases cGMP level up to 27-fold over basal level[1].
Naproxcinod (1-100 μM; 8 h) concentration-dependently increases HO-1 mRNA in endothelial cells[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis[2]

Cell Line: Endothelial and gastric mucosal cell lines
Concentration: 30-1000 μM
Incubation Time: 8 and 24 hours
Result: Increased HO-1 protein levels in endothelial and gastric mucosal cells and increased HO-1mRNA levels in endothelial cells.
In Vivo

Naproxcinod (0-41 mg/kg; p.o. once daily for 42 weeks) shows a significantly higher mean BW (7.3%) than vehicle group and improves skeletal and cardiac disease phenotype in the mouse model of DMD[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/10 mice with Duchenne muscular dystrophy (DMD)[3]
Dosage: 0, 10, 21 and 41 mg/kg
Administration: Oral gavage; 0-41 mg/kg once daily for 42 weeks
Result: Significantly improved fraction shortening and ejection fraction, and reduced inflammation in vivo.
Clinical Trial
Molecular Weight

347.36

Formula

C18H21NO6

CAS No.
SMILES

C[C@@H](C1=CC=C2C=C(OC)C=CC2=C1)C(OCCCCO[N+]([O-])=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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Naproxcinod Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Naproxcinod
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HY-14931
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