2. Immunology/Inflammation Apoptosis Anti-infection
  3. COX Apoptosis Parasite
  4. Ibuprofen L-lysine

Ibuprofen L-lysine  (Synonyms: (±)-Ibuprofen L-lysine)

Cat. No.: HY-100586 Purity: 99.91%
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Ibuprofen ((±)-Ibuprofen) L-lysine is a potent orally active, selective COX-1 inhibitor with an IC50 value of 13 μM. Ibuprofen L-lysine inhibits cell proliferation, angiogenesis, and induces cell apoptosis. Ibuprofen L-lysine is a nonsteroidal anti-inflammatory agent and a nitric oxide (NO) donor. Ibuprofen L-lysine can be used in the research of pain, swelling, inflammation, infection, immunology, cancers.

For research use only. We do not sell to patients.

CAS No. : 57469-77-9

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water
ready for reconstitution
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10 mM * 1 mL in Water In-stock
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Customer Review

Based on 22 publication(s) in Google Scholar

Other Forms of Ibuprofen L-lysine:

Ibuprofen L-lysine Related Antibodies

Top Publications Citing Use of Products

    Ibuprofen L-lysine purchased from MedChemExpress. Usage Cited in: Inflammopharmacology. 2024 Feb;32(1):733-745.  [Abstract]

    The inhibitory effect of Ibuprofen (0-3 mM, 48 h) on the proliferation of C643 and OCUT-2C cells was detected by CCK8 assay.

    Ibuprofen L-lysine purchased from MedChemExpress. Usage Cited in: Inflammopharmacology. 2024 Feb;32(1):733-745.  [Abstract]

    Transwell assay, cells were treated with various concentrations of Ibuprofen (C643 at 0, 0.5, 1, and 1.5 mM; OCUT-2C at 0, 1, 2, and 3 mM) for 48 h view cell invasion abilities.

    Ibuprofen L-lysine purchased from MedChemExpress. Usage Cited in: Inflammopharmacology. 2024 Feb;32(1):733-745.  [Abstract]

    Wound healing assay, cells were treated with different concentrations of Ibuprofen (C643 at 0, 0.5, 1, and 1.5 mM; OCUT-2C at 0, 1, 2, and 3 mM) for 48 h view cell migration abilities.

    Ibuprofen L-lysine purchased from MedChemExpress. Usage Cited in: Inflammopharmacology. 2024 Feb;32(1):733-745.  [Abstract]

    Flow cytometry analysis of ATC cells treated with different Ibuprofen (0-3 mM) concentrations for 48 h stained with Annexin V-FITC and PI.

    Ibuprofen L-lysine purchased from MedChemExpress. Usage Cited in: Inflammopharmacology. 2024 Feb;32(1):733-745.  [Abstract]

    The effect of Ibuprofen (0-1.5 mM) on LDH activity in C643 and OCUT-2C cells.

    Ibuprofen L-lysine purchased from MedChemExpress. Usage Cited in: Inflammopharmacology. 2024 Feb;32(1):733-745.  [Abstract]

    Ibuprofen-induced expression of GSDMD protein in C643 and OCUT-2C cells.

    Ibuprofen L-lysine purchased from MedChemExpress. Usage Cited in: Cell Rep. 2019 Dec 17;29(12):3847-3858.e5.  [Abstract]

    Effects of Ibuprofen (10 mg/kg, i.p.) or indomethacin (10 mg/kg, i.p.) on pain thresholds at day 3 after CFA treatment.

    Ibuprofen L-lysine purchased from MedChemExpress. Usage Cited in: Cell Rep. 2019 Dec 17;29(12):3847-3858.e5.  [Abstract]

    Effects of Ibuprofen (10 mg/kg, i.p.), Indomethacin, Gabapentin, or Lidocaine on pain thresholds of CRS 3W mice.

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    • Biological Activity

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    • References

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    Description

    Ibuprofen ((±)-Ibuprofen) L-lysine is a potent orally active, selective COX-1 inhibitor with an IC50 value of 13 μM. Ibuprofen L-lysine inhibits cell proliferation, angiogenesis, and induces cell apoptosis. Ibuprofen L-lysine is a nonsteroidal anti-inflammatory agent and a nitric oxide (NO) donor. Ibuprofen L-lysine can be used in the research of pain, swelling, inflammation, infection, immunology, cancers[1][2][3][4][5][6][7][8].

    IC50 & Target

    IC50: 13 μM (COX-1), 370 μM (COX-2)
    In Vitro

    Ibuprofen (24 h) L-lysine inhibits COX-1 and COX-2 activity with IC50 values of 13 μM and 370 μM[1].
    Ibuprofen (500 μM, 48 h) L-lysine inhibits cell proliferation and angiogenesis, and induces apoptosis in AGS cells (Adenocarcinoma gastric cell line)[2].
    Ibuprofen (500 μM, 48 h) L-lysine downregulates transcription of Akt, VEGF-A, PCNA, Bcl2, OCT3/4 and CD44 genes, but upregulates RNA levels of wild type P53 and Bax genes in AGS cell[2].
    Ibuprofen (500 μM, 24 h) L-lysine restores microtubule reformation, microtubule-dependent intracellular cholesterol transport, and induces extension of microtubules to the cell periphery in both cystic fibrosis (CF) cell models and primary CF nasal epithelial cells[3].
    Ibuprofen (500 μM, 24 h) L-lysine enhances UV-induced cell death in MCF-7 cells and MDA-MB-231 cells by a photosensitization process[4].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Ibuprofen L-lysine Related Antibodies

    Cell Viability Assay[2]

    Cell Line: AGS cells
    Concentration: 100-1000 μM
    Incubation Time: 24 h, 48 h
    Result: Inhibited AGS cell viability with IC50 values of 630 μM (trypan blue staining, 24 h), 456 μM (neutral red assay, 24 h), 549 μM (trypan blue staining, 48 h) and 408 μM (neutral red assay, 48 h).
    In Vivo

    Ibuprofen (300 mg/kg; p.o.; daily, for 14 days) L-lysine reduces overall tumor growth and enhances anti-tumor immune characteristics without adverse autoimmune reactions in a model of postpartum breast cancer[5].
    Ibuprofen (60 mg/kg; i.h.; every second day for 15 days) L-lysine reduces the risk of neuropathy in a rat model of chronic Oxaliplatin induced peripheral neuropathy[6].
    Ibuprofen (20 mg/kg; p.o.; every 12 hours, 5 doses total) L-lysine decreases muscle growth (average muscle fiber cross-sectional area) without affecting regulation of supraspinatus tendon adaptions to exercise[7].
    Ibuprofen (35 mg/kg; p.o.; twice daily) L-lysine attenuates the Inflammatory response to pseudomonas aeruginosa in a rat model of chronic pulmonary infection[8].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Syngeneic (D2A1) orthotopic Balb/c mouse model of PPBC (postpartum)[5]
    Dosage: 300 mg/kg, daily for 14 days
    Administration: Fed in animal feedings (added to pulverized standard chow and mixed dry, then mixed with water, made into chow pellets and dried thoroughly)
    Result: Suppresed tumor growth, reduced presence of immature monocytes and increased numbers of T cells.
    Enhanced Th1 associated cytokines as well as promoted tumor border accumulation of T cells.
    Animal Model: Oxaliplatin‑induced peripheral neuropathy[6]
    Dosage: 60 mg/kg, every second day for 15 days
    Administration: Subcutaneous injection
    Result: Lowered sensory nerve conduction velocity (SNCV).
    Clinical Trial
    Molecular Weight

    352.47

    Formula

    C19H32N2O4
    CAS No.
    Appearance

    Solid

    Color

    White to off-white

    SMILES

    CC(C(O)=O)C1=CC=C(CC(C)C)C=C1.OC([C@@H](N)CCCCN)=O
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    4°C, sealed storage, away from moisture

    *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

    Solvent & Solubility
    In Vitro: 

    H2O : 100 mg/mL (283.71 mM; Need ultrasonic)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 2.8371 mL 14.1856 mL 28.3712 mL
    5 mM 0.5674 mL 2.8371 mL 5.6742 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

    • Molarity Calculator

    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start)

    C1

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    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

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    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Calculation results:
    Working solution concentration: mg/mL
    This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
    Purity & Documentation

    Purity: 99.91%

    SDS (394 KB)

    COA (252 KB) HNMR (251 KB) LCMS (88 KB)

    Handling Instructions (2659 KB)
    References

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    H2O 1 mM 2.8371 mL 14.1856 mL 28.3712 mL 70.9280 mL
    5 mM 0.5674 mL 2.8371 mL 5.6742 mL 14.1856 mL
    10 mM 0.2837 mL 1.4186 mL 2.8371 mL 7.0928 mL
    15 mM 0.1891 mL 0.9457 mL 1.8914 mL 4.7285 mL
    20 mM 0.1419 mL 0.7093 mL 1.4186 mL 3.5464 mL
    25 mM 0.1135 mL 0.5674 mL 1.1348 mL 2.8371 mL
    30 mM 0.0946 mL 0.4729 mL 0.9457 mL 2.3643 mL
    40 mM 0.0709 mL 0.3546 mL 0.7093 mL 1.7732 mL
    50 mM 0.0567 mL 0.2837 mL 0.5674 mL 1.4186 mL
    60 mM 0.0473 mL 0.2364 mL 0.4729 mL 1.1821 mL
    80 mM 0.0355 mL 0.1773 mL 0.3546 mL 0.8866 mL
    100 mM 0.0284 mL 0.1419 mL 0.2837 mL 0.7093 mL

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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    Ibuprofen L-lysine Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Ibuprofen57469-77-9(±)-IbuprofenCOXApoptosisParasiteCyclooxygenaseangiogenesisinflammationAGSgastric canceranti-tumoranti-cancermicrotubulecystic fibrosisphotosensitivitybreast cancerT cellstumor microenvironmentNeuroprotectionInhibitorinhibitorinhibit

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