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SMS2-IN-2 

Cat. No.: HY-112713
Handling Instructions

SMS2-IN-2 is a potent, highly selective and orally active sphingomyelin synthase 2 (SMS2) inhibitor, with IC50s of 100 nM and 56 μM for SMS2 and SMS1, respectively. Anti-chronic inflammatory activity.

For research use only. We do not sell to patients.

SMS2-IN-2 Chemical Structure

SMS2-IN-2 Chemical Structure

CAS No. : 2241838-28-6

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Description

SMS2-IN-2 is a potent, highly selective and orally active sphingomyelin synthase 2 (SMS2) inhibitor, with IC50s of 100 nM and 56 μM for SMS2 and SMS1, respectively. Anti-chronic inflammatory activity[1].

IC50 & Target

IC50: 100 nM (SMS2), 56 μM (SMS1)[1]

In Vivo

SMS2-IN-2 (Compound 15w; 20, 50 mg/kg/day, p.o. for 6 weeks) reduces chronic inflammation in the db/db mice[1].

Animal Model: Type 2 diabetes mellitus (T2DM) db/db mouse model (four-to-five week)[1]
Dosage: 20, 50 mg/kg/day
Administration: P.O. daily for 6 weeks
Result: Significantly reduced IL-6 and insulin levels.
References
Molecular Weight

369.78

Formula

C₁₉H₁₃ClFN₃O₂

CAS No.

2241838-28-6

SMILES

ClC(C=CC(F)=C1)=C1COC2=CC=CC3=C2C(NC4=CC=CN=C4)=NO3

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

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This equation is commonly abbreviated as: C1V1 = C2V2

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Product Name:
SMS2-IN-2
Cat. No.:
HY-112713
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SMS2-IN-2

Cat. No.: HY-112713