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SMS2-IN-2 

Cat. No.: HY-112713 Purity: >98.0%
Handling Instructions

SMS2-IN-2 is a potent, highly selective and orally active sphingomyelin synthase 2 (SMS2) inhibitor, with IC50s of 100 nM and 56 μM for SMS2 and SMS1, respectively. Anti-chronic inflammatory activity.

For research use only. We do not sell to patients.

SMS2-IN-2 Chemical Structure

SMS2-IN-2 Chemical Structure

CAS No. : 2241838-28-6

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 385 In-stock
Estimated Time of Arrival: December 31
5 mg USD 350 In-stock
Estimated Time of Arrival: December 31
10 mg USD 550 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1650 In-stock
Estimated Time of Arrival: December 31
100 mg USD 2250 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

Top Publications Citing Use of Products
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Description

SMS2-IN-2 is a potent, highly selective and orally active sphingomyelin synthase 2 (SMS2) inhibitor, with IC50s of 100 nM and 56 μM for SMS2 and SMS1, respectively. Anti-chronic inflammatory activity[1].

IC50 & Target

IC50: 100 nM (SMS2), 56 μM (SMS1)[1]

In Vivo

SMS2-IN-2 (Compound 15w; 20, 50 mg/kg/day, p.o. for 6 weeks) reduces chronic inflammation in the db/db mice[1].

Animal Model: Type 2 diabetes mellitus (T2DM) db/db mouse model (four-to-five week)[1]
Dosage: 20, 50 mg/kg/day
Administration: P.O. daily for 6 weeks
Result: Significantly reduced IL-6 and insulin levels.
Molecular Weight

369.78

Formula

C₁₉H₁₃ClFN₃O₂

CAS No.

2241838-28-6

SMILES

ClC(C=CC(F)=C1)=C1COC2=CC=CC3=C2C(NC4=CC=CN=C4)=NO3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (338.04 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7043 mL 13.5216 mL 27.0431 mL
5 mM 0.5409 mL 2.7043 mL 5.4086 mL
10 mM 0.2704 mL 1.3522 mL 2.7043 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (5.62 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (5.62 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

SMS2-IN-2OthersInhibitorinhibitorinhibit

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Product name:
SMS2-IN-2
Cat. No.:
HY-112713
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