2. Metabolic Enzyme/Protease
  3. Ser/Thr Protease
  4. Alirocumab

Alirocumab  (Synonyms: REGN 727; SAR 236553)

Cat. No.: HY-P9928 Purity: 97%
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Alirocumab (REGN 727) is a human monoclonal antibody inhibitor of PCSK9. Alirocumab is a monoclonal antibody. Alirocumab has anti-inflammatory, antiangiogenic and antioxidant effects. Alirocumab can be used in the study of hypercholesterolemia.

For research use only. We do not sell to patients.

Alirocumab Chemical Structure

Alirocumab Chemical Structure

CAS No. : 1245916-14-6

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Based on 1 publication(s) in Google Scholar

Alirocumab Related Antibodies

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Description

Alirocumab (REGN 727) is a human monoclonal antibody inhibitor of PCSK9. Alirocumab is a monoclonal antibody. Alirocumab has anti-inflammatory, antiangiogenic and antioxidant effects. Alirocumab can be used in the study of hypercholesterolemia[1][2][3][4][5].

In Vitro

Alirocumab (0.01, 0.1, 1, 2 and 10 μM, 24-72 h) does not affect cell viability and function in hiPSC-CMs and hESC-CMs, and can be used to evaluate drug safety in lipid-lowering cardiovascular cells[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Alirocumab Related Antibodies

Cell Viability Assay[3]

Cell Line: hiPSC-CMs, hESC-CMs
Concentration: 0.01, 0.1, 1, 2, 10 μM
Incubation Time: 24-72 h
Result: Exhibited normal cell viability and did not affect the level of LDH release.
In Vivo

Alirocumab (3 or 10 mg/kg, subcutaneous injection weekly for 18 weeks) inhibits atherosclerosis, improves the plaque morphology, and enhances the effects of a statin[4].
Alirocumab (10 mg/kg, intraperitoneal injection at day 0, 10, 20) inhibits PCSK9 in rats and improves systemic oxidative stress and hyperlipidemia in BDL-induced cirrhosis rats[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: CETP mice model[4]
Dosage: 3 or 10 mg/kg
Administration: s.c.
Result: Decreased total cholesterol dose-dependently.
Increased hepatic LDL receptor protein levels but did not affect hepatic cholesterol and TG content.
Decreased atherosclerotic lesion size and improved plaque morphology.
Animal Model: Rat model (240-280 g) [5]
Dosage: 10 mg/kg
Administration: i.p.
Result: Elevated ammonia, total cholesterol, LDL and ox-LDL levels.
Decreased plasma levels of total cholesterol, LDL, and oxidative stress markers.
Clinical Trial
CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

OC(CO)COP(O)(O)=O.[Na].[Na]
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation

Purity: 97%

COA (291 KB)

Handling Instructions (2659 KB)
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Alirocumab Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Alirocumab1245916-14-6REGN 727 SAR 236553REGN727REGN-727SAR236553SAR 236553SAR-236553Ser/Thr ProteaseSerine proteasesSerine endopeptidasesThreonine proteasesPraluentPCSK9InhibitorhiPSC-CMshESC-CMsLDLCETP mice modelAnti-inflammatoryinhibitorinhibit

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