PCSK9 - proprotein convertase subtilisin/kexin type 9 Gene

Homo sapiens

Also known as FH3; PC9; FHCL3; NARC1; LDLCQ1; NARC-1; HCHOLA3

Gene ID: 255738 | Gene type: protein coding

About PCSK9

Cytogenetic location: 1p32.3 Genomic coordinates (GRCh38): 1:55,039,548-55,064,852 (from NCBI)

This gene has 6 transcripts (splice variants), 158 orthologues, 9 paralogues and is associated with 4 phenotypes. Biased expression in lung (RPKM 5.3), liver (RPKM 3.3) and 9 other tissues.

Summary

This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The encoded protein undergoes an autocatalytic processing event with its prosegment in the ER and is constitutively secreted as an inactive protease into the extracellular matrix and trans-Golgi network. It is expressed in liver, intestine and kidney tissues and escorts specific receptors for lysosomal degradation. It plays a role in Cholesterol and fatty acid metabolism. Mutations in this gene have been associated with autosomal dominant familial hypercholesterolemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]

PCSK9 Products(9)

mRNA	Protein	Name
NM_001407240.1	NP_001394169.1	proprotein convertase subtilisin/kexin type 9 isoform 2 preproprotein
NM_001407241.1	NP_001394170.1	proprotein convertase subtilisin/kexin type 9 isoform 3 preproprotein
NM_001407242.1	NP_001394171.1	proprotein convertase subtilisin/kexin type 9 isoform 4 preproprotein
NM_001407243.1	NP_001394172.1	proprotein convertase subtilisin/kexin type 9 isoform 5 preproprotein
NM_001407244.1	NP_001394173.1	proprotein convertase subtilisin/kexin type 9 isoform 6 preproprotein
NM_001407245.1	NP_001394174.1	proprotein convertase subtilisin/kexin type 9 isoform 7 preproprotein
NM_001407246.1	NP_001394175.1	proprotein convertase subtilisin/kexin type 9 isoform 8
NM_001407247.1	NP_001394176.1	proprotein convertase subtilisin/kexin type 9 isoform 9 preproprotein
NM_174936.4	NP_777596.2	proprotein convertase subtilisin/kexin type 9 isoform 1 preproprotein

PCSK9 Protein Structure

Inhibitor_I9

Peptidase_S8

0
200
400
600
692 a.a.

Protein Preferred Names

Protein Names

proprotein convertase subtilisin/kexin type 9

convertase subtilisin/kexin type 9 preproprotein

Recombinant PCSK9 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70545	PCSK9 Protein, Human (HEK293, V474I, G670E, His)	Q8NBP7 (Q31-Q692, V474I, G670E)	≥95%
HY-P70546	PCSK9 Protein, Human (Biotinylated, V474I, G670E, HEK293, His-HA-Avi)	Q8NBP7 (Q31-Q692, V474I, G670E）	≥95%
HY-P72405	PCSK9 Protein, Human (Biotinylated, V474I, G670E, HEK293, Avi)	Q8NBP7 (Q31-Q692, V474I, G670E)	≥95%
HY-P73338	PCSK9 Protein, Human (Biotinylated, HEK293, His-Avi)	Q8NBP7 (Q31-Q692)	≥95%
HY-P73728	PCSK9 Protein, Human (HEK293, Fc)	Q8NBP7/NP_777596.2 (Q31-Q692)	≥95%
HY-P76982	PCSK9 Protein, Human (D374Y, V474I, G670E, HEK293, His)	Q8NBP7 (Q31-Q692, D374Y, V474I, G670E)	≥95%
HY-P78663	PCSK9 Protein, Human (D374Y, HEK293, His)	Q8NBP7 (Q31-Q692, D374Y)	≥95%
HY-P78824	PCSK9 Protein, Human (Biotinylated, HEK293, D374Y, His-Avi)	Q8NBP7 (Q31-Q692, D374Y)	≥95%
HY-P70545A	PCSK9 Protein, Human (HEK293, C-His)	Q8NBP7 (Q31-Q692)	≥95%

Related Diseases

Diseases

Alias

Hypercholesterolemia, Familial, 3

Hypercholesterolemia, Autosomal Dominant, 3	FHCL3
Hchola3	Fh3
Low Density Lipoprotein Cholesterol Level Qtl 1	Hypercholesterolemia, Familial, Type 3
Hypercholesterolemia

Homozygous Familial Hypercholesterolemia

Hofh

Familial Hypercholesterolemia

Hyperlipoproteinemia Type Iia	Familial Hyperbetalipoproteinaemia
Familial Hypercholesteremia	Fredrickson Type Iia Hyperlipoproteinemia
Fredrickson Type Iia Lipidaemia	Hyperbetalipoproteinemia
Type Ii Hyperlipidemia	Familial Hypercholesterolæmia
Familial Hypercholesterolaemia	Fh
Hypercholesterolemia Familial	Hyperlipoproteinemia Type Ii
Hypercholesterolemia, Familial

Hypercholesterolemia, Familial, 1

Hypercholesterolemia	FHCL1
Fhc	Fh
Hyperlipoproteinemia, Type Ii	Hyperlipoproteinemia, Type Iia
Hyper-Low-Density-Lipoproteinemia	Hypercholesterolemic Xanthomatosis, Familial
Ldl Receptor Disorder	Hypercholesterolemia, Susceptibility To
Hypercholesterolemia, Familial, Modifier Of	Hypercholesterolemia, Familial, Due To Ldlr Defect, Modifier Of
Ldl Cholesterol Level Qtl2	Hyperlipoproteinemia Type Ii
Hypercholesterolemia, Familial, Type 1	High Cholesterol
Increased Cholesterol	Low-Density-Lipoid-Type Hyperlipoproteinemia
Pure Hypercholesterolaemia	Ldl - [Low Density Lipoprotein} Hyperlipoproteinemia
Group A Hyperlipidaemia	Pure Hypercholesterinaemia
Cholesterolaemia	Essential Cholesterolaemia
Essential Hypercholesterolaemia	Group A Hyperlipemia
Increased Low Density Lipoprotein	Low-Density-Lipoprotein-Type
Low-Density-Lipoprotein-Type Hyperlipoproteinemia

Hypercholesterolemia, Familial, 4

Hypercholesterolemia, Autosomal Recessive	Arh
FHCL4	Autosomal Recessive Hypercholesterolemia
Arh1	Arh2
Autosomal Recessive Hypercholesterolemia 1	Autosomal Recessive Hypercholesterolemia 2
Fhcb1	Fhcb2
Hypercholesterolemia, Autosomal Recessive, 1, Formerly	Arh1, Formerly
Fhcb1, Formerly	Hypercholesterolemia, Autosomal Recessive, 2, Formerly
Arh2, Formerly	Fhcb2, Formerly
Familial Autosomal Recessive Hypercholesterolemia	Hypercholesterolemia, Familial, Autosomal Recessive
Hypercholesterolemia, Familial, Type 4

Familial Hyperlipidemia

Familial Hyperlipoproteinemia	Hyperlipidaemia
Hyperlipoproteinemias	Hyperlipidemia
Hyperlipemia	Hyperlipidemias

Coronary Stenosis

Coronary Artery Stenosis

Hypobetalipoproteinemia, Familial, 1

Hypobetalipoproteinemia	Familial Hypobetalipoproteinemia 1
Familial Hypobetalipoproteinemia	FHBL1
Hypobetalipoproteinemia, Familial	Fhbl
Acanthocytosis With Hypobetalipoproteinemia	Hypobetalipoproteinemias
Hypobetalipoproteinemia, Normotriglyceridemic	Hypo-Beta-Lipoproteinemia
Hypobetalipoprotéinemia, Familial	Normotriglyceridemic Hypobetalipoproteinemia
Hypobetalipoproteinemia, Familial, Type 1

Arcus Corneae

Arcus Senilis	Corneal Arcus
Arcus Of Cornea

Corneal Degeneration

Degenerative Corneal Opacity

Heart Disease

Heart Failure	Congenital Heart Disease
Heart Diseases	Congenital Heart Defects
Congenital Heart Defect	Heart Malformation
Congenital Anomaly Of Heart	Heart Defect
Heart-Congenital Defect	Congenital Heart Disorder
Heart Defects Congenital	Heart Defects, Congenital
Heart Defects	Heart Disease, Congenital
Disease, Heart, Congenital	Congestive Heart Failure

Niemann-Pick Disease

Sphingomyelin/Cholesterol Lipidosis	Niemann-Pick Diseases
Lipoid Histiocytosis	Sphingomyelin Lipidosis
Sphingomyelinase Deficiency Disease	Lipid Histiocytosis
Neuronal Cholesterol Lipidosis	Neuronal Lipidosis
Npd	Sphingomyelinase Deficiency
Niemann-Pick Disease, Type A

Hypobetalipoproteinemia, Familial, 2

Familial Hypobetalipoproteinemia 2	FHBL2
Hypolipidemia, Familial, Combined	Combined Familial Hypolipidemia
Combined Hypobetalipoproteinemia Familial	Hypobetalipoproteinemia, Familial, Type 2

Nasopharyngitis

Chronic Nasopharyngitis

Chronic Rhinopharyngitis

Sitosterolemia

Phytosterolemia	Beta-Sitosterolemia
Plant Sterol Storage Disease	Phytosterolæmia
Sitosterolæmia	Retention Of Dietary Cholesterol And Abnormal Retention Of Non-Cholesterol Sterols In The Body
Phytosterolaemia	Sitosterolaemia
Sitosterolemia With Xanthomatosis

Peripheral Artery Disease

Peripheral Arterial Disease

Peripheral Arterial Diseases

Hypolipoproteinemia

Hypolipoproteinaemia	Lipoprotein Deficiencies
Lipoprotein Disorder	Hypolipoproteinemias
Lipoprotein	Lipoprotein Deficiency
Hypolipidaemia	Lipoprotein Deficiency Disorder
High-Density Lipoid Deficiency	High-Density Lipoprotein Deficiency
Dyslipidaemia, Depressed Hdl Cholesterol

Atherosclerosis Susceptibility

Atherosclerosis	Atherosclerosis, Susceptibility To
ATHS	Atherogenic Lipoprotein Phenotype
Alp	Arteriosclerosis

Coronary Heart Disease 1

Coronary Heart Disease	Coronary Heart Disease, Susceptibility To, 1
Chds1	Coronary Heart Disease, Susceptibility To
CHD	Heart, Coronary, Disease, Susceptibility To, Type 1
Coronary Arteriosclerosis	Coronary Artery Disease

Intermediate Coronary Syndrome

Unstable Angina	Angina At Rest
Anginal Chest Pain At Rest	Impending Infarction
Preinfarction Angina	Worsening Angina
Angina, Unstable	Myocardial Preinfarction Syndrome
Angina Unstable	Crescendo Angina
Angina Decubitus	Acute Coronary Insufficiency
Unstable Angina Pectoris	Preinfarctional Angina Pectoris
Worsening Effort Angina	Preinfarction Syndrome
Unstable Angina Pectoris Syndrome	Unstable Anginal Attack
Unstable Cardiac Angina	Unstable Chest Angina
Unstable Heart Angina	De Novo Effort Angina Pectoris
Crescendo Angina Pectoris	Ua - [Unstable Angina]

Hyperlipoproteinemia, Type I

Lipoprotein Lipase Deficiency	Familial Chylomicronemia Syndrome
Lpl Deficiency	Hyperchylomicronemia, Familial
Hyperlipemia, Idiopathic, Burger-Grutz Type	Hyperlipemia, Essential Familial
Lipase D Deficiency	Lipd Deficiency
Hyperlipoproteinemia, Type Ia	Chylomicronemia, Familial
High Density Lipoprotein Cholesterol Level Qtl 11	Hyperlipoproteinemia Type 1
Hyperlipoproteinemia 1	HLPP1
Lipoprotein Lipase	Hyperlipoproteinemia Type I
Familial Hyperchylomicronemia Syndrome

Cardiovascular System Disease

Abnormality Of The Cardiovascular System	Cardiovascular Disease
Disease Of Subdivision Of Hemolymphoid System	Disorder Of Cardiovascular System
Cardiovascular Diseases

Tyrosinemia, Type I

Tyrosinemia Type I	Hepatorenal Tyrosinemia
Fumarylacetoacetase Deficiency	Fah Deficiency
TYRSN1	Fumarylacetoacetate Hydrolase Deficiency
Tyrosinemia Type 1	Tyrosinemia 1
Fumarylacetoacetase

Amyloidosis, Hereditary, Transthyretin-Related

Transthyretin Amyloidosis	Familial Amyloid Polyneuropathy
Ttr Amyloid Neuropathy	Transthyretin Amyloid Neuropathy
Transthyretin Amyloid Polyneuropathy	Fap
Familial Transthyretin Amyloidosis	Amyloidosis Transthyretin Related
Type I Familial Amyloid Polyneuropathy	Familial Amyloid Polyneuropathy Type I
Attrv122i Amyloidosis	Hereditary Amyloidosis, Transthyretin-Related
Amyloid Polyneuropathy, Familial	Attr Amyloidosis
Attrm Amyloidosis	Corino De Andrade'S Disease
Paramyloidosis	Transthyretin-Related Hereditary Amyloidosis
Ttr Amyloidosis	Hereditary Attr Amyloidosis
Portuguese Polyneuritic Amyloidosis	Portuguese Type Familial Amyloid Neuropathy
Swiss Type Amyloid Polyneuropathy	Type Ii Familial Amyloid Polyneuropathy
Attrv30m Amyloidosis	Attrv30m-Related Amyloidosis
Familial Amyloid Polyneuropathy, Portuguese-Swedish-Japanese Type	Attr Cardiomyopathy
Attrv122i-Related Amyloidosis	Ttr-Related Amyloid Cardiomyopathy
Ttr-Related Cardiac Amyloidosis	Transthyretin Amyloid Cardiopathy
Transthyretin-Related Familial Amyloid Cardiomyopathy	Amyloidosis, Transthyretin-Related
AMYL-TTR	Amyloidosis I
Amyloidosis Ohio Type	Amyloidosis Type 7
Amyloidosis Vii	Amyloid Polyneuropathy
Attr	Familial Amyloid Polyneuropathy Type Ii
Hereditary Amyloidosis Transthyretin-Related	Leptomeningeal Amyloidosis
Meningocerebrovascular Amyloidosis	Oculoleptomeningeal Amyloidosis
Familial Amyloid Polyneuropathies	Amyloidosis, Leptomeningeal
Senile Cardiac Amyloidosis	Amyloid Neuropathies, Familial
Danish Type Familial Amyloid Cardiomyopathy	Familial Amyloid Neuropathy, Portuguese Type
Amyloid Polyneuropathy, Swiss Type	Hereditary Oculoleptomeningeal Amyloid Angiopathy
Amyloid Neuropathies

Neural Tube Defects

Spina Bifida	Neural Tube Defect
NTD	Neural Tube Defects, Susceptibility To
Spinal Dysraphism	Spina Bifida, Susceptibility To
Rachischisis	Cleft Spine
Open Spine	Hydrocele Spinalis
Neural Tube Defect Nos	Sb - [Spina Bifida]
Spinal Hernia Nos	Spinal Fissure Nos

Hypothyroidism

Thyroid Diseases	Thyroid Disease
Thyroid Deficiency	Thyroid Insufficiency
Dysfunction Thyroid	Thyroid Dysfunction

Myocardial Infarction

Heart Attack	Myocardial Infarction, Susceptibility To
Myocardial Infarction 1	Myocardial Infarction, Protection Against
Myocardial Infarction, Decreased Susceptibility To	Myocardial Infarction, Decreased
Myocardial Infarct	MCI1
Premature Myocardial Infarction	Myocardial Infarction, Susceptibility To, Type 1

Tyrosinemia

Hypertyrosinemia	Tyrosinemias
Hereditary Tyrosinemia	Hypertyrosinaemia
Tyrosinaemia	Hereditary Hypertyrosinemia

Nephrotic Syndrome

Finnish Congenital Nephrotic Syndrome	Ns - [Nephrotic Syndrome]
Nephrosis Syndrome	Nephrosis Nos
Glomerular Lesion Nephrosis

Aortic Valve Disease 2

Aortic Valve Stenosis	Aortic Stenosis
Rheumatic Aortic Stenosis	AOVD2
Bicuspid Aortic Valve	Rheumatic Aortic Valve Stenosis
Valvular Aortic Stenosis	Aortic Valve Disease, Type 2
Aortic Valve Stricture	Aortic Valve Obstruction
Obstructed Aorta Valve	Rheumatic Aortic Obstruction
Rheumatic Aortic Valve Obstruction	Rheumatic Aortic Stricture
Aortic Valve Regurgitation	Aortic Insufficiency With Stenosis
Rheumatic Aortic Valve Stenosis With Insufficiency	Rheumatic Aortic Stenosis With Incompetence
Rheumatic Aortic Stenosis With Regurgitation

Hyperlipidemia, Familial Combined, 3

Familial Combined Hyperlipidemia	Combined Hyperlipidemia, Familial
Mixed Hyperlipidaemia	FCHL3
Hyperlipidemia, Familial Combined	Familial Multiple Lipoprotein-Type Hyperlipidemia
Hyperbetalipoproteinemia With Prebetalipoproteinemia	Type Iib Hyperlipoproteinemia
Hyperlipidemia Familial Combined	Hyperlipoproteinemia Type Iib
Mixed Hyperlipemia	Hyperlipidaemia, Group C
Familial Hypercholesterolaemia With Hyperlipaemia	Familial Hyperbetalipoproteinaemia And Hyperprebetalipoproteinaemia
Hyperbetalipoproteinaemia With Prebetalipoproteinaemia	Hypercholesterolaemia With Endogenous Hyperglyceridaemia
Prebetalipoproteinemia Hyperbetalipoproteinaemia	Remnant Hyperlipoproteinemia

Lipid Metabolism Disorder

Dyslipidemia	Disorder Of Fatty Acid Metabolism
Lipid Metabolism Disorders	Fatty Acid Metabolism Disorder
Disorder Of Lipid Metabolism	Abnormality Of Lipid Metabolism
Lipid Metabolism, Inborn Errors	Dyslipidemias
Disorders Of Lipid Metabolism	Congenital Disorders Of Lipid Metabolism
Inherited Disorders Of Lipid Metabolism

Carotid Artery Disease

Carotid Artery Diseases

Disorder Of Carotid Artery

Diabetes Mellitus

Diabetes

Chronic Ethmoiditis

Chronic Ethmoidal Sinusitis	Chronic Ethmoid Sinusitis
Ethmoidal Sinusitis - Chronic

Solid Adenocarcinoma With Mucin Production

Hypertension, Essential

Essential Hypertension	Hypertension
High Blood Pressure	Hypertension, Essential, Susceptibility To
Hypertensive Disease	Primary Hypertension
EHT	Hypertension, Salt-Sensitive Essential, Susceptibility To
Hyperpiesia	Idiopathic Hypertension
Hypertensive Disorder	Hypertension, Essential, Susceptibility To, 3
Hypertension, Essential 3	Hypertension, Essential, Salt-Sensitive
Hypertension, Essential, Susceptibility To, 6	Hypertension, Essential 6
Hypertension, Salt-Sensitive Essential	Hypertension, Susceptibility To
Hypertension, Essential, Susceptibility To, 4	Hypertension, Essential 4
Hypertension, Essential, Susceptibility To, 2	Hypertension, Essential 2
Hypertension, Essential, Susceptibility To, 1	Hypertension, Essential 1
Hypertension, Essential, Susceptibility To, 5	Hypertension, Essential 5
Htn	Vascular Hypertensive Disorder
Systemic Primary Arterial Hypertension	Hbp - [High Blood Pressure]
Systemic Arterial Hypertensive Disorder	Elevated Blood Pressure
Arterial Hypertension Nos	Hypertension Nos
Benign Hypertension	Systemic Arterial Hypertension
Systemic Hypertension	Artery Htn
Benign Htn	Vascular Htn
Vascular Hypertension	Cholesterol Hypertension
Cholesterol Htn	Idiopathic Htn
Malignant Hypertension	Malignant Htn
Raised Blood Pressure	Cardiovascular Hypertension
Primary Htn - [Hypertension]	High Arterial Tension
High Blood Pressure Disorder	Ht - [Hypertension]
Htn - [Hypertension]	Hypertensive Vascular Disease
Hypertensive Vascular Degeneration

Type 2 Diabetes Mellitus

Insulin Resistance	NIDDM
Type 2 Diabetes	Diabetes Mellitus, Non-Insulin-Dependent
T2D	Noninsulin-Dependent Diabetes Mellitus
Diabetes Mellitus, Type Ii	Maturity-Onset Diabetes
Insulin Resistance, Severe, Digenic	Diabetes Mellitus, Type 2
Diabetes Mellitus, Noninsulin-Dependent	Diabetes Mellitus, Noninsulin-Dependent, Association With
Diabetes Mellitus, Noninsulin-Dependent, Late Onset	Hypertension, Insulin Resistance-Related, Susceptibility To
Insulin Resistance, Susceptibility To	Non-Insulin-Dependent Diabetes Mellitus
Type Ii Diabetes Mellitus	Adult-Onset Diabetes Mellitus
Maturity-Onset Diabetes Mellitus	Diabetes Mellitus Type 2
Type Ii Diabetes	Type 2 Diabetes Mellitus, Susceptibility To
Diabetes, Type 2	Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To
Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To	Diabetes Mellitus, Type 2, Susceptibility To
Diabetes Mellitus, Noninsulin-Dependent, 2	Diabetes Mellitus, Type Ii, Susceptibility To
Hypertension, Insulin Resistance-Related	Adult-Onset Diabetes
Aodm	Diabetes Mellitus, Adult-Onset
Diabetes Mellitus Type Ii	Diabetes Mellitus Type 2, Susceptibility To
Diabetes, Type Ii, Susceptibility To	Diabetes Type 2
Diabetes Mellitus	Adult Onset Diabetes
Maturity Onset Diabetes	Nonketotic Diabetes
Non-Insulin Dependent Diabetes Mellitus	T2dm - [Type 2 Diabetes Mellitus]
Niddm - [Non Insulin Dependent Diabetes Mellitus]	Dm2
Dm Type Ii	Diabetic Type 2
Insulin Requiring Type 2 Diabetes	Noninsulin Dependent Diabetes
Non-Insulin-Dependent Diabetes Mellitus Without Complications	Diabetes Due To Insulin Secretory Defect
Diabetes Mellitus Due To Insulin Secretory Defect	Non-Insulin-Dependent Diabetes Of The Young
Senile Diabetes	Nonketotic Hyperglycaemia
Stable Diabetes

Nervous System Disease

Abnormality Of The Nervous System	Nervous System Diseases
Nervous System Disorder

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-132591	Inclisiran	Inhibitor	91.03%	Unkown

Inhibitory Antibodies (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P9930	Evolocumab	Inhibitor	98.40%	Unkown
HY-P9928	Alirocumab	Inhibitor	97.00%	Unkown

Clinical Phase

Inhibitory Antibodies (8)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P9928A	Alirocumab (anti-PCSK9)	Inhibitor	99.00%	Phase 4
HY-P99187	Bococizumab	Inhibitor	99.9%	Phase 3
HY-P99696	Lerodalcibep		/	Phase 3
HY-P99773	Ongericimab	Inhibitor	/	Phase 3
HY-P99822	Recaticimab	Inhibitor	99.71%	Phase 3
HY-P99871	Ebronucimab		/	Phase 3
HY-P99552	Tafolecimab		/	Phase 3
HY-P99626	Frovocimab	Inhibitor	/	Phase 2

Pre-clinical Phase

Bioactive Molecules (49)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-120088A	PF-06446846 hydrochloride	Inhibitor	99.85%	Unkown
HY-12402	SBC-115076	Inhibitor	99.54%	Unkown
HY-P2276	Pep2-8	Inhibitor	99.74%	Unkown
HY-101354	R-IMPP	Inhibitor	98.42%	Unkown
HY-148673	PCSK9-IN-12		99.97%	Unkown
HY-152221	PCSK9-IN-10	Inhibitor	98.95%	Unkown
HY-132591A	Inclisiran sodium	Inhibitor	98.10%	Unkown
HY-N2127	Pinostrobin		99.98%	Unkown
HY-101832	SBC-110736	Inhibitor	99.93%	Unkown
HY-143219	SS-Inclisiran sodium		98.88%	Unkown
HY-143221	AS-Inclisiran sodium		96.58%	Unkown
HY-112598A	PF-06815345 hydrochloride	Inhibitor	98.15%	Unkown
HY-141714	SBC-115337	Inhibitor	98.05%	Unkown
HY-150223	GalNAc unconjugated/naked Inclisiran	Inhibitor	92.95%	Unkown
HY-130245	PCSK9 degrader 1		98.26%	Unkown
HY-152223	PCSK9-IN-11	Inhibitor	99.66%	Unkown
HY-143220	SS(no Galnac)-Inclisiran sodium		97.78%	Unkown
HY-148687	SPC5001		93.97%	Unkown
HY-17640	Nicodicosapent	Inhibitor	98.04%	Unkown
HY-W510159	5-O-Methylembelin	Inhibitor	98.84%	Unkown
HY-112598	PF-06815345	Inhibitor	/	Unkown
HY-143223	AS(3n-2)-Inclisiran	Inhibitor	93.89%	Unkown
HY-148687A	SPC5001 sodium		93.97%	Unkown
HY-148758	PCSK9-IN-13	Inhibitor	98.00%	Unkown
HY-139998	PCSK9-IN-3	Inhibitor	/	Unkown
HY-120088	PF-06446846	Inhibitor	/	Unkown
HY-128334	PCSK9 modulator-2		/	Unkown
HY-132897	PCSK9-IN-2	Inhibitor	/	Unkown
HY-134482	PCSK9-IN-1	Inhibitor	/	Unkown
HY-141724	PCSK9 ligand 1	Inhibitor	/	Unkown
HY-146084	PCSK9 modulator-3		/	Unkown
HY-146085	PCSK9 modulator-4		/	Unkown
HY-147252	Bezeparsen	Inhibitor	/	Unkown
HY-147252A	Bezeparsen sodium	Inhibitor	/	Unkown
HY-148689	SPC4061	Inhibitor	/	Unkown
HY-148689A	SPC4061 sodium	Inhibitor	/	Unkown
HY-149310	Dim16	Inhibitor	/	Unkown
HY-153391	PCSK9-IN-14	Inhibitor	/	Unkown
HY-153451	PCSK9-IN-15	Inhibitor	/	Unkown
HY-153452	PCSK9-IN-16	Inhibitor	/	Unkown
HY-153453	PCSK9-IN-17	Inhibitor	/	Unkown
HY-153454	PCSK9-IN-18	Inhibitor	/	Unkown
HY-155006	PCSK9-IN-19		/	Unkown
HY-155415	PCSK9-IN-20	Inhibitor	/	Unkown
HY-157434	PCSK9-IN-23	Inhibitor	/	Unkown
HY-160036	PCSK9-IN-22	Inhibitor	/	Unkown
HY-163141	PCSK9-IN-24	Inhibitor	/	Unkown
HY-N10702	PCSK9-IN-9	Inhibitor	/	Unkown
HY-RS10177	PCSK9 Human Pre-designed siRNA Set A		/	Unkown

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P99816	Ralpancizumab	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	PCSK9	RGD	RGD:728909
Macaca mulatta	PCSK9	VGNC	VGNC:100028
Mus musculus	PCSK9	MGD	MGI:2140260
Macaca fascicularis	PCSK9	NCBI
Others	PCSK9	NCBI