PCSK9 - proprotein convertase subtilisin/kexin type 9 Gene

Also Known as FH3; PC9; FHCL3; NARC1; LDLCQ1; NARC-1; HCHOLA3

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 255738

About PCSK9

Cytogenetic location: 1p32.3 Genomic coordinates (GRCh38): 1:55,039,548-55,064,852 (from NCBI)

This gene has 6 transcripts (splice variants), 158 orthologues, 9 paralogues and is associated with 4 phenotypes. Biased expression in lung (RPKM 5.3), liver (RPKM 3.3) and 9 other tissues.

Summary

This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The encoded protein undergoes an autocatalytic processing event with its prosegment in the ER and is constitutively secreted as an inactive protease into the extracellular matrix and trans-Golgi network. It is expressed in liver, intestine and kidney tissues and escorts specific receptors for lysosomal degradation. It plays a role in Cholesterol and fatty acid metabolism. Mutations in this gene have been associated with autosomal dominant familial hypercholesterolemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]

PCSK9 Products (9)

mRNA	Protein	Name
NM_001407240.1	NP_001394169.1	proprotein convertase subtilisin/kexin type 9 isoform 2 preproprotein
NM_001407241.1	NP_001394170.1	proprotein convertase subtilisin/kexin type 9 isoform 3 preproprotein
NM_001407242.1	NP_001394171.1	proprotein convertase subtilisin/kexin type 9 isoform 4 preproprotein
NM_001407243.1	NP_001394172.1	proprotein convertase subtilisin/kexin type 9 isoform 5 preproprotein
NM_001407244.1	NP_001394173.1	proprotein convertase subtilisin/kexin type 9 isoform 6 preproprotein
NM_001407245.1	NP_001394174.1	proprotein convertase subtilisin/kexin type 9 isoform 7 preproprotein
NM_001407246.1	NP_001394175.1	proprotein convertase subtilisin/kexin type 9 isoform 8
NM_001407247.1	NP_001394176.1	proprotein convertase subtilisin/kexin type 9 isoform 9 preproprotein
NM_174936.4	NP_777596.2	proprotein convertase subtilisin/kexin type 9 isoform 1 preproprotein

PCSK9 Protein Structure

Inhibitor_I9

Peptidase_S8

0
200
400
600
692 a.a.

Protein Preferred Names	Protein Names
proprotein convertase subtilisin/kexin type 9	convertase subtilisin/kexin type 9 preproprotein

PCSK9 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	PCSK9	Q8NBP7	MMP2	Homo sapiens	P08253	Zymography	25613181
Intra	PCSK9	Q8NBP7	MMP2	Homo sapiens	P08253	Enzymatic Study	25613181
Intra	PCSK9	Q8NBP7	MMP2	Homo sapiens	P08253	BN-PAGE	25613181
Intra	PCSK9	Q8NBP7	ANXA2	Homo sapiens	P07355	Confocal	18799458
Intra	PCSK9	Q8NBP7	ANXA2	Homo sapiens	P07355	Far-WB	18799458
Intra	PCSK9	Q8NBP7	LDLR	Homo sapiens	P01130	SPR	22081141

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant PCSK9 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70545	PCSK9 Protein, Human (HEK293, V474I, G670E, His)	Q8NBP7-1 (Q31-Q692, V474I, G670E)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P70546	PCSK9 Protein, Human (Biotinylated, V474I, G670E, HEK293, His-HA-Avi)	Q8NBP7-1 (Q31-Q692, V474I, G670E)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P72405	PCSK9 Protein, Human (Biotinylated, V474I, G670E, HEK293, Avi)	Q8NBP7-1 (Q31-Q692, V474I, G670E)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P73728	PCSK9 Protein, Human (HEK293, mFc)	Q8NBP7-1/NP_777596.2 (Q31-Q692)	≥ 90%, as determined by reducing SDS-PAGE.
HY-P78663	PCSK9 Protein, Human (D374Y, HEK293, His)	Q8NBP7-1 (Q31-Q692, D374Y)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P78824	PCSK9 Protein, Human (Biotinylated, D374Y, HEK293, His-Avi)	Q8NBP7-1 (Q31-Q692, D374Y)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P70545A	PCSK9 Protein, Human (HEK293, C-His)	Q8NBP7-1 (Q31-Q692)	≥ 95%, as determined by reducing SDS-PAGE.

PCSK9 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P81805	PCSK9 Antibody (YA1550)	WB, IP	Human
HY-P81805A	PCSK9 Antibody (YA1550)(PBS only)	WB, IP	Human
HY-P85725	PCSK9 Antibody (YA5417)	IHC-P	Human

Related Diseases

Diseases	Alias
Hypercholesterolemia, Familial, 3	Hypercholesterolemia, Autosomal Dominant, 3 FHCL3 Hchola3 Fh3 Low Density Lipoprotein Cholesterol Level Qtl 1 Hypercholesterolemia, Familial, Type 3 Hypercholesterolemia
Homozygous Familial Hypercholesterolemia	Hofh
Familial Hypercholesterolemia	Hyperlipoproteinemia Type Iia Familial Hyperbetalipoproteinaemia Familial Hypercholesteremia Fredrickson Type Iia Hyperlipoproteinemia Fredrickson Type Iia Lipidaemia Hyperbetalipoproteinemia Type Ii Hyperlipidemia Familial Hypercholesterolæmia Familial Hypercholesterolaemia Fh Hypercholesterolemia Familial Hyperlipoproteinemia Type Ii Hypercholesterolemia, Familial
Hypercholesterolemia, Familial, 1	Hypercholesterolemia FHCL1 Fhc Fh Hyperlipoproteinemia, Type Ii Hyperlipoproteinemia, Type Iia Hyper-Low-Density-Lipoproteinemia Hypercholesterolemic Xanthomatosis, Familial Ldl Receptor Disorder Hypercholesterolemia, Susceptibility To Hypercholesterolemia, Familial, Modifier Of Hypercholesterolemia, Familial, Due To Ldlr Defect, Modifier Of Ldl Cholesterol Level Qtl2 Hyperlipoproteinemia Type Ii Hypercholesterolemia, Familial, Type 1 High Cholesterol Increased Cholesterol Low-Density-Lipoid-Type Hyperlipoproteinemia Pure Hypercholesterolaemia Ldl - [Low Density Lipoprotein} Hyperlipoproteinemia Group A Hyperlipidaemia Pure Hypercholesterinaemia Cholesterolaemia Essential Cholesterolaemia Essential Hypercholesterolaemia Group A Hyperlipemia Increased Low Density Lipoprotein Low-Density-Lipoprotein-Type Low-Density-Lipoprotein-Type Hyperlipoproteinemia
Hypercholesterolemia, Familial, 4	Hypercholesterolemia, Autosomal Recessive Arh FHCL4 Autosomal Recessive Hypercholesterolemia Arh1 Arh2 Autosomal Recessive Hypercholesterolemia 1 Autosomal Recessive Hypercholesterolemia 2 Fhcb1 Fhcb2 Hypercholesterolemia, Autosomal Recessive, 1, Formerly Arh1, Formerly Fhcb1, Formerly Hypercholesterolemia, Autosomal Recessive, 2, Formerly Arh2, Formerly Fhcb2, Formerly Familial Autosomal Recessive Hypercholesterolemia Hypercholesterolemia, Familial, Autosomal Recessive Hypercholesterolemia, Familial, Type 4
Familial Hyperlipidemia	Familial Hyperlipoproteinemia Hyperlipidaemia Hyperlipoproteinemias Hyperlipidemia Hyperlipemia Hyperlipidemias
Coronary Stenosis	Coronary Artery Stenosis
Hypobetalipoproteinemia, Familial, 1	Hypobetalipoproteinemia Familial Hypobetalipoproteinemia 1 Familial Hypobetalipoproteinemia FHBL1 Hypobetalipoproteinemia, Familial Fhbl Acanthocytosis With Hypobetalipoproteinemia Hypobetalipoproteinemias Hypobetalipoproteinemia, Normotriglyceridemic Hypo-Beta-Lipoproteinemia Hypobetalipoprotéinemia, Familial Normotriglyceridemic Hypobetalipoproteinemia Hypobetalipoproteinemia, Familial, Type 1
Arcus Corneae	Arcus Senilis Corneal Arcus Arcus Of Cornea
Corneal Degeneration	Degenerative Corneal Opacity
Heart Disease	Heart Failure Congenital Heart Disease Heart Diseases Congenital Heart Defects Congenital Heart Defect Heart Malformation Congenital Anomaly Of Heart Heart Defect Heart-Congenital Defect Congenital Heart Disorder Heart Defects Congenital Heart Defects, Congenital Heart Defects Heart Disease, Congenital Disease, Heart, Congenital Congestive Heart Failure
Niemann-Pick Disease	Sphingomyelin/Cholesterol Lipidosis Niemann-Pick Diseases Lipoid Histiocytosis Sphingomyelin Lipidosis Sphingomyelinase Deficiency Disease Lipid Histiocytosis Neuronal Cholesterol Lipidosis Neuronal Lipidosis Npd Sphingomyelinase Deficiency Niemann-Pick Disease, Type A
Hypobetalipoproteinemia, Familial, 2	Familial Hypobetalipoproteinemia 2 FHBL2 Hypolipidemia, Familial, Combined Combined Familial Hypolipidemia Combined Hypobetalipoproteinemia Familial Hypobetalipoproteinemia, Familial, Type 2
Nasopharyngitis	Chronic Nasopharyngitis Chronic Rhinopharyngitis
Sitosterolemia	Phytosterolemia Beta-Sitosterolemia Plant Sterol Storage Disease Phytosterolæmia Sitosterolæmia Retention Of Dietary Cholesterol And Abnormal Retention Of Non-Cholesterol Sterols In The Body Phytosterolaemia Sitosterolaemia Sitosterolemia With Xanthomatosis
Peripheral Artery Disease	Peripheral Arterial Disease Peripheral Arterial Diseases
Hypolipoproteinemia	Hypolipoproteinaemia Lipoprotein Deficiencies Lipoprotein Disorder Hypolipoproteinemias Lipoprotein Lipoprotein Deficiency Hypolipidaemia Lipoprotein Deficiency Disorder High-Density Lipoid Deficiency High-Density Lipoprotein Deficiency Dyslipidaemia, Depressed Hdl Cholesterol
Atherosclerosis Susceptibility	Atherosclerosis Atherosclerosis, Susceptibility To ATHS Atherogenic Lipoprotein Phenotype Alp Arteriosclerosis
Coronary Heart Disease 1	Coronary Heart Disease Coronary Heart Disease, Susceptibility To, 1 Chds1 Coronary Heart Disease, Susceptibility To CHD Heart, Coronary, Disease, Susceptibility To, Type 1 Coronary Arteriosclerosis Coronary Artery Disease
Intermediate Coronary Syndrome	Unstable Angina Angina At Rest Anginal Chest Pain At Rest Impending Infarction Preinfarction Angina Worsening Angina Angina, Unstable Myocardial Preinfarction Syndrome Angina Unstable Crescendo Angina Angina Decubitus Acute Coronary Insufficiency Unstable Angina Pectoris Preinfarctional Angina Pectoris Worsening Effort Angina Preinfarction Syndrome Unstable Angina Pectoris Syndrome Unstable Anginal Attack Unstable Cardiac Angina Unstable Chest Angina Unstable Heart Angina De Novo Effort Angina Pectoris Crescendo Angina Pectoris Ua - [Unstable Angina]
Hyperlipoproteinemia, Type I	Lipoprotein Lipase Deficiency Familial Chylomicronemia Syndrome Lpl Deficiency Hyperchylomicronemia, Familial Hyperlipemia, Idiopathic, Burger-Grutz Type Hyperlipemia, Essential Familial Lipase D Deficiency Lipd Deficiency Hyperlipoproteinemia, Type Ia Chylomicronemia, Familial High Density Lipoprotein Cholesterol Level Qtl 11 Hyperlipoproteinemia Type 1 Hyperlipoproteinemia 1 HLPP1 Lipoprotein Lipase Hyperlipoproteinemia Type I Familial Hyperchylomicronemia Syndrome
Cardiovascular System Disease	Abnormality Of The Cardiovascular System Cardiovascular Disease Disease Of Subdivision Of Hemolymphoid System Disorder Of Cardiovascular System Cardiovascular Diseases
Tyrosinemia, Type I	Tyrosinemia Type I Hepatorenal Tyrosinemia Fumarylacetoacetase Deficiency Fah Deficiency TYRSN1 Fumarylacetoacetate Hydrolase Deficiency Tyrosinemia Type 1 Tyrosinemia 1 Fumarylacetoacetase
Amyloidosis, Hereditary, Transthyretin-Related	Transthyretin Amyloidosis Familial Amyloid Polyneuropathy Ttr Amyloid Neuropathy Transthyretin Amyloid Neuropathy Transthyretin Amyloid Polyneuropathy Fap Familial Transthyretin Amyloidosis Amyloidosis Transthyretin Related Type I Familial Amyloid Polyneuropathy Familial Amyloid Polyneuropathy Type I Attrv122i Amyloidosis Hereditary Amyloidosis, Transthyretin-Related Amyloid Polyneuropathy, Familial Attr Amyloidosis Attrm Amyloidosis Corino De Andrade'S Disease Paramyloidosis Transthyretin-Related Hereditary Amyloidosis Ttr Amyloidosis Hereditary Attr Amyloidosis Portuguese Polyneuritic Amyloidosis Portuguese Type Familial Amyloid Neuropathy Swiss Type Amyloid Polyneuropathy Type Ii Familial Amyloid Polyneuropathy Attrv30m Amyloidosis Attrv30m-Related Amyloidosis Familial Amyloid Polyneuropathy, Portuguese-Swedish-Japanese Type Attr Cardiomyopathy Attrv122i-Related Amyloidosis Ttr-Related Amyloid Cardiomyopathy Ttr-Related Cardiac Amyloidosis Transthyretin Amyloid Cardiopathy Transthyretin-Related Familial Amyloid Cardiomyopathy Amyloidosis, Transthyretin-Related AMYL-TTR Amyloidosis I Amyloidosis Ohio Type Amyloidosis Type 7 Amyloidosis Vii Amyloid Polyneuropathy Attr Familial Amyloid Polyneuropathy Type Ii Hereditary Amyloidosis Transthyretin-Related Leptomeningeal Amyloidosis Meningocerebrovascular Amyloidosis Oculoleptomeningeal Amyloidosis Familial Amyloid Polyneuropathies Amyloidosis, Leptomeningeal Senile Cardiac Amyloidosis Amyloid Neuropathies, Familial Danish Type Familial Amyloid Cardiomyopathy Familial Amyloid Neuropathy, Portuguese Type Amyloid Polyneuropathy, Swiss Type Hereditary Oculoleptomeningeal Amyloid Angiopathy Amyloid Neuropathies
Neural Tube Defects	Spina Bifida Neural Tube Defect NTD Neural Tube Defects, Susceptibility To Spinal Dysraphism Spina Bifida, Susceptibility To Rachischisis Cleft Spine Open Spine Hydrocele Spinalis Neural Tube Defect Nos Sb - [Spina Bifida] Spinal Hernia Nos Spinal Fissure Nos
Hypothyroidism	Thyroid Diseases Thyroid Disease Thyroid Deficiency Thyroid Insufficiency Dysfunction Thyroid Thyroid Dysfunction
Myocardial Infarction	Heart Attack Myocardial Infarction, Susceptibility To Myocardial Infarction 1 Myocardial Infarction, Protection Against Myocardial Infarction, Decreased Susceptibility To Myocardial Infarction, Decreased Myocardial Infarct MCI1 Premature Myocardial Infarction Myocardial Infarction, Susceptibility To, Type 1
Tyrosinemia	Hypertyrosinemia Tyrosinemias Hereditary Tyrosinemia Hypertyrosinaemia Tyrosinaemia Hereditary Hypertyrosinemia
Nephrotic Syndrome	Finnish Congenital Nephrotic Syndrome Ns - [Nephrotic Syndrome] Nephrosis Syndrome Nephrosis Nos Glomerular Lesion Nephrosis
Aortic Valve Disease 2	Aortic Valve Stenosis Aortic Stenosis Rheumatic Aortic Stenosis AOVD2 Bicuspid Aortic Valve Rheumatic Aortic Valve Stenosis Valvular Aortic Stenosis Aortic Valve Disease, Type 2 Aortic Valve Stricture Aortic Valve Obstruction Obstructed Aorta Valve Rheumatic Aortic Obstruction Rheumatic Aortic Valve Obstruction Rheumatic Aortic Stricture Aortic Valve Regurgitation Aortic Insufficiency With Stenosis Rheumatic Aortic Valve Stenosis With Insufficiency Rheumatic Aortic Stenosis With Incompetence Rheumatic Aortic Stenosis With Regurgitation
Hyperlipidemia, Familial Combined, 3	Familial Combined Hyperlipidemia Combined Hyperlipidemia, Familial Mixed Hyperlipidaemia FCHL3 Hyperlipidemia, Familial Combined Familial Multiple Lipoprotein-Type Hyperlipidemia Hyperbetalipoproteinemia With Prebetalipoproteinemia Type Iib Hyperlipoproteinemia Hyperlipidemia Familial Combined Hyperlipoproteinemia Type Iib Mixed Hyperlipemia Hyperlipidaemia, Group C Familial Hypercholesterolaemia With Hyperlipaemia Familial Hyperbetalipoproteinaemia And Hyperprebetalipoproteinaemia Hyperbetalipoproteinaemia With Prebetalipoproteinaemia Hypercholesterolaemia With Endogenous Hyperglyceridaemia Prebetalipoproteinemia Hyperbetalipoproteinaemia Remnant Hyperlipoproteinemia
Lipid Metabolism Disorder	Dyslipidemia Disorder Of Fatty Acid Metabolism Lipid Metabolism Disorders Fatty Acid Metabolism Disorder Disorder Of Lipid Metabolism Abnormality Of Lipid Metabolism Lipid Metabolism, Inborn Errors Dyslipidemias Disorders Of Lipid Metabolism Congenital Disorders Of Lipid Metabolism Inherited Disorders Of Lipid Metabolism
Carotid Artery Disease	Carotid Artery Diseases Disorder Of Carotid Artery
Diabetes Mellitus	Diabetes
Chronic Ethmoiditis	Chronic Ethmoidal Sinusitis Chronic Ethmoid Sinusitis Ethmoidal Sinusitis - Chronic
Solid Adenocarcinoma With Mucin Production
Hypertension, Essential	Essential Hypertension Hypertension High Blood Pressure Hypertension, Essential, Susceptibility To Hypertensive Disease Primary Hypertension EHT Hypertension, Salt-Sensitive Essential, Susceptibility To Hyperpiesia Idiopathic Hypertension Hypertensive Disorder Hypertension, Essential, Susceptibility To, 3 Hypertension, Essential 3 Hypertension, Essential, Salt-Sensitive Hypertension, Essential, Susceptibility To, 6 Hypertension, Essential 6 Hypertension, Salt-Sensitive Essential Hypertension, Susceptibility To Hypertension, Essential, Susceptibility To, 4 Hypertension, Essential 4 Hypertension, Essential, Susceptibility To, 2 Hypertension, Essential 2 Hypertension, Essential, Susceptibility To, 1 Hypertension, Essential 1 Hypertension, Essential, Susceptibility To, 5 Hypertension, Essential 5 Htn Vascular Hypertensive Disorder Systemic Primary Arterial Hypertension Hbp - [High Blood Pressure] Systemic Arterial Hypertensive Disorder Elevated Blood Pressure Arterial Hypertension Nos Hypertension Nos Benign Hypertension Systemic Arterial Hypertension Systemic Hypertension Artery Htn Benign Htn Vascular Htn Vascular Hypertension Cholesterol Hypertension Cholesterol Htn Idiopathic Htn Malignant Hypertension Malignant Htn Raised Blood Pressure Cardiovascular Hypertension Primary Htn - [Hypertension] High Arterial Tension High Blood Pressure Disorder Ht - [Hypertension] Htn - [Hypertension] Hypertensive Vascular Disease Hypertensive Vascular Degeneration
Type 2 Diabetes Mellitus	Insulin Resistance NIDDM Type 2 Diabetes Diabetes Mellitus, Non-Insulin-Dependent T2D Noninsulin-Dependent Diabetes Mellitus Diabetes Mellitus, Type Ii Maturity-Onset Diabetes Insulin Resistance, Severe, Digenic Diabetes Mellitus, Type 2 Diabetes Mellitus, Noninsulin-Dependent Diabetes Mellitus, Noninsulin-Dependent, Association With Diabetes Mellitus, Noninsulin-Dependent, Late Onset Hypertension, Insulin Resistance-Related, Susceptibility To Insulin Resistance, Susceptibility To Non-Insulin-Dependent Diabetes Mellitus Type Ii Diabetes Mellitus Adult-Onset Diabetes Mellitus Maturity-Onset Diabetes Mellitus Diabetes Mellitus Type 2 Type Ii Diabetes Type 2 Diabetes Mellitus, Susceptibility To Diabetes, Type 2 Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To Diabetes Mellitus, Type 2, Susceptibility To Diabetes Mellitus, Noninsulin-Dependent, 2 Diabetes Mellitus, Type Ii, Susceptibility To Hypertension, Insulin Resistance-Related Adult-Onset Diabetes Aodm Diabetes Mellitus, Adult-Onset Diabetes Mellitus Type Ii Diabetes Mellitus Type 2, Susceptibility To Diabetes, Type Ii, Susceptibility To Diabetes Type 2 Diabetes Mellitus Adult Onset Diabetes Maturity Onset Diabetes Nonketotic Diabetes Non-Insulin Dependent Diabetes Mellitus T2dm - [Type 2 Diabetes Mellitus] Niddm - [Non Insulin Dependent Diabetes Mellitus] Dm2 Dm Type Ii Diabetic Type 2 Insulin Requiring Type 2 Diabetes Noninsulin Dependent Diabetes Non-Insulin-Dependent Diabetes Mellitus Without Complications Diabetes Due To Insulin Secretory Defect Diabetes Mellitus Due To Insulin Secretory Defect Non-Insulin-Dependent Diabetes Of The Young Senile Diabetes Nonketotic Hyperglycaemia Stable Diabetes
Nervous System Disease	Abnormality Of The Nervous System Nervous System Diseases Nervous System Disorder

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval
Clinical Phase
Pre-clinical Phase

Approval

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-132591A	Inclisiran sodium	Inhibitor	99.08%	Unkown
HY-132591	Inclisiran	Inhibitor	99.48%	Unkown
HY-132591C	Inclisiran sodium scrambled negative control	Inhibitor	/	Unkown

Inhibitory Antibodies (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P9928	Alirocumab	Inhibitor	97.00%	Unkown
HY-P99696	Lerodalcibep		/	Unkown

Clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Phase
HY-12090	Anacetrapib	Inhibitor	99.25%	Phase 3
HY-158825	Cepadacursen sodium		/	Phase 2
HY-148687A	SPC5001 sodium	Inhibitor	98.89%	Phase 1
HY-112598	PF-06815345	Inhibitor	/	Phase 1

Inhibitory Antibodies (6)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P99822	Recaticimab	Inhibitor	99.71%	Phase 4
HY-P99552	Tafolecimab	Inhibitor	95.04%	Phase 4
HY-P99187	Bococizumab	Inhibitor	99.80%	Phase 3
HY-P99871	Ebronucimab	Inhibitor	/	Phase 3
HY-P99773	Ongericimab	Inhibitor	/	Phase 3
HY-P99626	Frovocimab	Inhibitor	96.78%	Phase 2

Pre-clinical Phase

Bioactive Molecules (72)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-148673	Laroprovstat	Inhibitor	99.93%	Unkown
HY-P4153	Enlicitide chloride	Inhibitor	99.63%	Unkown
HY-120088A	PF-06446846 hydrochloride	Inhibitor	99.44%	Unkown
HY-143219	SS-Inclisiran sodium	Inhibitor	97.91%	Unkown
HY-12402	SBC-115076	Inhibitor	99.28%	Unkown
HY-P2276	Pep2-8	Inhibitor	99.74%	Unkown
HY-W510159	5-O-Methylembelin	Inhibitor	99.43%	Unkown
HY-143220	SS(no Galnac)-Inclisiran sodium	Inhibitor	98.05%	Unkown
HY-150223	GalNAc unconjugated/naked Inclisiran	Inhibitor	94.67%	Unkown
HY-152221	PCSK9-IN-10	Inhibitor	98.89%	Unkown
HY-152223	PCSK9-IN-11	Inhibitor	99.30%	Unkown
HY-101354	R-IMPP	Inhibitor	99.93%	Unkown
HY-157434	PCSK9-IN-23	Inhibitor	99.57%	Unkown
HY-148758	PCSK9-IN-13	Inhibitor	98.00%	Unkown
HY-130245	PCSK9 degrader 1	Degrader	98.33%	Unkown
HY-101832	SBC-110736	Inhibitor	99.55%	Unkown
HY-142026	Vitisin A	Inhibitor	96%	Unkown
HY-141714	SBC-115337	Inhibitor	98.02%	Unkown
HY-163794	DC371739	Inhibitor	95.56%	Unkown
HY-158827A	AZD8233 sodium		94.99%	Unkown
HY-120088	PF-06446846	Inhibitor	98.35%	Unkown
HY-162562	E28362	Inhibitor	94.51%	Unkown
HY-161939	7030B-C5	Inhibitor	99.78%	Unkown
HY-P2276A	Pep2-8 TFA	Inhibitor	98.78%	Unkown
HY-161940	PCSK9-IN-30	Inhibitor	/	Unkown
HY-148687	SPC5001	Inhibitor	95.11%	Unkown
HY-147252A	Bezeparsen sodium	Inhibitor	95.21%	Unkown
HY-112598A	PF-06815345 hydrochloride	Inhibitor	98.15%	Unkown
HY-159595	PCSK9-IN-29	Inhibitor	99.44%	Unkown
HY-148626	CVI-LM001	Inhibitor	/	Unkown
HY-W1126955	Enlicitide (decanoate)	Inhibitor	/	Unkown
HY-147252	Bezeparsen	Inhibitor	/	Unkown
HY-148689	SPC4061	Inhibitor	/	Unkown
HY-RS10177	PCSK9 Human Pre-designed siRNA Set A	Inhibitor	/	Unkown
HY-161435	PCSK9-IN-27	Inhibitor	/	Unkown
HY-153453	PCSK9-IN-17	Inhibitor	/	Unkown
HY-149310	Dim16	Inhibitor	/	Unkown
HY-179106	PCSK9-IN-34	Inhibitor	/	Unkown
HY-161434	PCSK9-IN-26	Inhibitor	/	Unkown
HY-P11071	PCSK9 Inhibitor, EGF-A	Inhibitor	/	Unkown
HY-153452	PCSK9-IN-16	Inhibitor	/	Unkown
HY-130245A	(R,R)-PCSK9 degrader 1	Degrader	/	Unkown
HY-N10702	PCSK9-IN-9	Inhibitor	/	Unkown
HY-134482	PCSK9-IN-1	Inhibitor	/	Unkown
HY-148687C	SPC5001 sodium scrambled negative control	Inhibitor	/	Unkown
HY-141724	PCSK9 ligand 1	Inhibitor	/	Unkown
HY-153454	PCSK9-IN-18	Inhibitor	/	Unkown
HY-163141	PCSK9-IN-24	Inhibitor	/	Unkown
HY-P11216	Pep2-8 analogue 18	Inhibitor	/	Unkown
HY-153391	PCSK9-IN-14	Inhibitor	/	Unkown
HY-160036	PCSK9-IN-22	Inhibitor	/	Unkown
HY-146085	PCSK9 modulator-4	Modulator	/	Unkown
HY-128334	PCSK9 modulator-2	Modulator	/	Unkown
HY-148689C	SPC4061 sodium scrambled negative control	Inhibitor	/	Unkown
HY-176043	PCSK9 autophagic degrader 2	Degrader	/	Unkown
HY-153451	PCSK9-IN-15	Inhibitor	/	Unkown
HY-148689A	SPC4061 sodium	Inhibitor	/	Unkown
HY-146084	PCSK9 modulator-3	Modulator	/	Unkown
HY-161942	PCSK9-IN-31	Inhibitor	/	Unkown
HY-147252C	Bezeparsen sodium scrambled negative control	Inhibitor	/	Unkown
HY-161941	MeIm	Inhibitor	/	Unkown
HY-155006	PCSK9-IN-19	Inhibitor	/	Unkown
HY-18778C	Obicetrapib hemicalcium	Inhibitor	/	Unkown
HY-164344	PCSK9 allosteric binder-1		/	Unkown
HY-168156	PCSK9-IN-32	Inhibitor	/	Unkown
HY-158825A	Cepadacursen sodium scrambled negative control		/	Unkown
HY-175189	PCSK9-IN-33	Inhibitor	/	Unkown
HY-161938	BRD8518	Inhibitor	/	Unkown
HY-158827	AZD8233		/	Unkown
HY-158827B	AZD8233 sodium scrambled negative control		/	Unkown
HY-155415	PCSK9-IN-20	Inhibitor	/	Unkown
HY-149310A	Dim16 hydrochloride	Inhibitor	/	Unkown

Inhibitory Antibodies (8)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P9928A	Alirocumab (anti-PCSK9)	Inhibitor	98.24%	Unkown
HY-P99816	Ralpancizumab	Inhibitor	96.23%	Unkown
HY-P99251	Lodelcizumab	Inhibitor	≥99.0%	Unkown
HY-P99251	Lodelcizumab	Inhibitor	≥99.0%	Unkown
HY-P991721	Ticalicibart	Inhibitor	99.028%	Unkown
HY-P992407	MEDI-4166		/	Unkown
HY-P991343	ALD306	Inhibitor	/	Unkown
HY-P990485	Anti-PCSK9 Antibody	Inhibitor	98.39%	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	PCSK9	RGD	RGD:728909
Macaca mulatta	PCSK9	VGNC	VGNC:100028
Mus musculus	PCSK9	MGD	MGI:2140260
Others	PCSK9	NCBI