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Cat. No.: HY-163141

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PCSK9-IN-24

PCSK9-IN-24 (Compound OY3) is a compound that targets PCSK9. PCSK9-IN-24 reduces PCSK9 levels and increases LDL uptake and may be used in atherosclerosis research.

For research use only. We do not sell to patients.

CAS No.: 2974496-96-1
Formula: C₃₆H₃₆Br₂N₄O₆S
Molecular Weight:812.57

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

PCSK9-IN-24 Chemical Structure

CAS No.: 2974496-96-1

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

PCSK9-IN-24 (Compound OY3) is a compound that targets PCSK9. PCSK9-IN-24 reduces PCSK9 levels and increases LDL uptake and may be used in atherosclerosis research^[1].

Chemical Information

CAS No. 2974496-96-1
Molecular Weight 812.57
Formula C₃₆H₃₆Br₂N₄O₆S
SMILES

COC1=CC2=C(C=C1OCCCCN(C3=C/4C=C(C=C3)Br)C(C4=C/C5=CC(OC)=C(C(Br)=C5)O)=O)C(CC(NC6=NC=CS6)=O)(C)NCC2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Ouyang Z, et al. Targeted Degradation of PCSK9 In Vivo by Autophagy-Tethering Compounds. J Med Chem. 2024 Jan 11;67(1):433-449. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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