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Cat. No.: HY-W1126955

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Enlicitide (decanoate)

(Synonyms: MK-0616 (decanoate))

Enlicitide (MK-0616) decanoate is an orally active macrocyclic peptide PCSK9 inhibitor. Enlicitide decanoate binds to PCSK9, blocks its interaction with low-density lipoprotein receptor (LDLR), and enhances hepatic clearance of LDL-C. Enlicitide decanoate reduces atherogenic lipoproteins, including non-HDL cholesterol, apolipoprotein B, and lipoprotein (a). Enlicitide decanoate is applicable to research related to hypercholesterolemia, heterozygous familial hypercholesterolemia, and atherosclerotic cardiovascular disease.

For research use only. We do not sell to patients.

CAS No.: 2861205-06-1
Formula: C₉₂H₁₂₉FN₁₄O₁₇
Molecular Weight:1722.09

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Custom Peptide Synthesis

Enlicitide (decanoate) Chemical Structure

CAS No.: 2861205-06-1

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Bioz

Biological Activity

Description

In Vitro

Enlicitide decanoate specifically binds to the LDL receptor-binding domain of PCSK9, blocks the interaction between PCSK9 and LDL receptor, prevents PCSK9 from degrading LDL receptors on the surface of hepatocytes, thereby increasing the number of available LDL receptors on hepatocyte surface, enhancing the hepatic clearance efficiency of low-density lipoprotein cholesterol (LDL-C) in the blood, and achieving potent lipid-lowering effects^[1]^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2861205-06-1
Molecular Weight 1722.09
Formula C₉₂H₁₂₉FN₁₄O₁₇
Synonyms

MK-0616 (decanoate)
Sequence

Ala-{Dpr}-Phe-Trp-Pro-Thr-Tyr-Pro(Covalent bridge:Phe3-Pro5,Ala1-Trp4,Trp4-Pro8,Ala1-Pro8,D-Dpr2)
Sequence Shortening

A-{Dpr}-FWPTYP(Covalent bridge:Phe3-Pro5,Ala1-Trp4,Trp4-Pro8,Ala1-Pro8,D-Dpr2)
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Elbahloul MA, et al. The Oral PCSK9 inhibitor enlicitide for hypercholesterolemia. Eur J Intern Med. 2026 Mar 14:106835.
[Content Brief]

[2]. Merck. "Merck’s Enlicitide Decanoate, an Investigational Oral PCSK9 Inhibitor, Significantly Reduced LDL-C in Phase 3 CORALreef Lipids Trial." Merck, 8 Nov. 2025.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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