PF-06446846 hydrochloride
Based on 7 publication(s) in Google Scholar
PF-06446846 hydrochloride is an orally active and highly selective inhibitor of translation of Proprotein convertase subtilisin/kexin type 9 (PCSK9). PF-06446846 hydrochloride inhibits PCSK9 by inducing the ribosome to stall around codon 34.
For research use only. We do not sell to patients.
- Purity: 99.44%
- CAS No.: 1632250-50-0
- Formula: C22H21Cl2N7O
- Molecular Weight:470.35
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Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 2 years; -20°C, 1 year (sealed storage, away from moisture)
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Bioactive Compound Library Max
HY-L181
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Bioactive Compound Library
HY-L001
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Metabolism/Protease Compound Library
HY-L012
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Anti-Cardiovascular Disease Compound Library
HY-L046
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Orally Active Compound Library
HY-L061
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Heterocyclic Compound Library
HY-L138
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Highly Selective Inhibitors Library
HY-L158
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MCE Bioactive Compound Library
HY-L001V
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High-Throughput Bioactive Compound Library
HY-L205
Publications Citing Use of MedChemExpress (MCE) PF-06446846 hydrochloride
More- Cancer Commun (Lond). 2025 Aug;45(8):1010-1037. [Abstract]
- Protein Cell. 2021 Apr;12(4):240-260. [Abstract]
- Int J Biol Sci. 2024 Jul 15;20(10):3942-3955. [Abstract]
- BMC Cancer. 2024 Apr 10;24(1):445. [Abstract]
- IUBMB Life. 2026 Jun;78(6):e70119. [Abstract]
- Arch Oral Biol. 2025 Aug:176:106302. [Abstract]
- SSRN. 2025 Jun 18.
Biological Activity
PCSK9[1]
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male Sprague-Dawley (Crl:CD [SD] rats, 6-8 wk old at initiation of dosing)[1]
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Dosage:5, 15, and 50 mg/kg
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Administration:Oral gavage; daily for 14 days
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Result:Lowered plasma PCSK9 in a dose-dependent manner and lowered total cholesterol levels.
Chemical Information
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CAS No. 1632250-50-0
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Appearance Solid
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Molecular Weight 470.35
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Formula C22H21Cl2N7O
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Color Light yellow to yellow
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SMILES
O=C(N(C1=NC=CC=C1Cl)[C@H]2CNCCC2)C3=CC=C(N4N=NC5=CC=CN=C54)C=C3.[H]Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 2 years; -20°C, 1 year (sealed storage, away from moisture)
Publications (7)
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Journal Impact Factor
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Most Recent
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Cancer Commun (Lond)
Lipid metabolism reprograming by SREBP1-PCSK9 targeting sensitizes pancreatic cancer to immunochemotherapy. [Abstract]2025 Aug;45(8):1010-1037. PMID: 40439109 -
Protein Cell
Potentiating CD8+ T cell antitumor activity by inhibiting PCSK9 to promote LDLR-mediated TCR recycling and signaling. [Abstract]2021 Apr;12(4):240-260. PMID: 33606190 -
Int J Biol Sci
Inhibition of PCSK9 enhances the anti-hepatocellular carcinoma effects of TCR-T cells and anti-PD-1 immunotherapy. [Abstract]2024 Jul 15;20(10):3942-3955. PMID: 39113701 -
BMC Cancer
Targeting PCSK9 to upregulate MHC-II on the surface of tumor cells in tumor immunotherapy. [Abstract]2024 Apr 10;24(1):445. PMID: 38600469 -
IUBMB Life
Mechanism of PCSK9-Mediated Macrophage Activation via the CAP1/NF-κB Pathway in CAWS-Induced Kawasaki Disease Vasculitis. [Abstract]2026 Jun;78(6):e70119. PMID: 42276750 -
Arch Oral Biol
2025 Aug:176:106302. PMID: 40435597 -
Solvent & Solubility
DMSO : 100 mg/mL (212.61 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
H2O : 100 mg/mL (212.61 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year (sealed storage, away from moisture). When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year (sealed storage, away from moisture). When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 5 mg/mL (10.63 mM); Clear solution
This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.08 mg/mL (4.42 mM); Clear solution
This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 100 mg/mL (212.61 mM); Clear solution; Need ultrasonic and warming and heat to 60°C
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
Purity & Documentation
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Data Sheet (277 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year (sealed storage, away from moisture). When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO / H2O | 1 mM | 2.1261 mL | 10.6304 mL | 21.2608 mL | 53.1519 mL |
| 5 mM | 0.4252 mL | 2.1261 mL | 4.2522 mL | 10.6304 mL | |
| 10 mM | 0.2126 mL | 1.0630 mL | 2.1261 mL | 5.3152 mL | |
| 15 mM | 0.1417 mL | 0.7087 mL | 1.4174 mL | 3.5435 mL | |
| 20 mM | 0.1063 mL | 0.5315 mL | 1.0630 mL | 2.6576 mL | |
| 25 mM | 0.0850 mL | 0.4252 mL | 0.8504 mL | 2.1261 mL | |
| 30 mM | 0.0709 mL | 0.3543 mL | 0.7087 mL | 1.7717 mL | |
| 40 mM | 0.0532 mL | 0.2658 mL | 0.5315 mL | 1.3288 mL | |
| 50 mM | 0.0425 mL | 0.2126 mL | 0.4252 mL | 1.0630 mL | |
| 60 mM | 0.0354 mL | 0.1772 mL | 0.3543 mL | 0.8859 mL | |
| 80 mM | 0.0266 mL | 0.1329 mL | 0.2658 mL | 0.6644 mL | |
| 100 mM | 0.0213 mL | 0.1063 mL | 0.2126 mL | 0.5315 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
PF-06446846 hydrochloride Related Classifications
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