2. Metabolic Enzyme/Protease
  3. Ser/Thr Protease
  4. SBC-115076

SBC-115076 

Cat. No.: HY-12402 Purity: 99.54%
COA Handling Instructions

SBC-115076 is a potent proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitor. PCSK9 is a proprotein convertase, which plays a crucial role in LDL receptor metabolism.

For research use only. We do not sell to patients.

SBC-115076 Chemical Structure

SBC-115076 Chemical Structure

CAS No. : 489415-96-5

Size Price Stock Quantity
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Solid + Solvent
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 109 In-stock
Solution
10 mM * 1 mL in DMSO USD 109 In-stock
Solid
5 mg USD 99 In-stock
10 mg USD 132 In-stock
50 mg USD 462 In-stock
100 mg USD 715 In-stock
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500 mg   Get quote  

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This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

SBC-115076 Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE SBC-115076

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

SBC-115076 is a potent proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitor. PCSK9 is a proprotein convertase, which plays a crucial role in LDL receptor metabolism[1][2].

In Vivo

SBC-115076 (4 mg/kg; s.c.; daily for 3 weeks) reduces obesity and dyslipidemia, as well as improves insulin sensitivity in HFD-fed rats[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female Wistar rats (high-fat diet (HFD)- fed)[1]
Dosage: 4 mg/kg
Administration: S.c.; daily for 3 weeks
Result: Superior to atorvastatin in instigating weight loss, cholesterol reduction, and attenuation of mitochondrial oxidative stress in oxidative muscle fibers of obese female rats.
Molecular Weight

527.61

Appearance

Solid

Formula

C31H33N3O5
CAS No.
SMILES

O=C1N(CCCN2CCOCC2)C(C3=CC=NC=C3)C(C(C4=CC=C(OCC5=CC=CC=C5)C(C)=C4)=O)=C1O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (189.53 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8953 mL 9.4767 mL 18.9534 mL
5 mM 0.3791 mL 1.8953 mL 3.7907 mL
10 mM 0.1895 mL 0.9477 mL 1.8953 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.5 mg/mL (4.74 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 2.5 mg/mL (4.74 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% Corn Oil

    Solubility: ≥ 2.5 mg/mL (4.74 mM); Clear solution

*All of the co-solvents are available by MedChemExpress (MCE).
Purity & Documentation
References
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SBC-115076 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

SBC-115076489415-96-5SBC115076SBC 115076Ser/Thr ProteaseSerine proteasesSerine endopeptidasesThreonine proteasesobesityinsulinsensitivityHFD-fedratsLDLInhibitorinhibitorinhibit

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