489415-96-5
489415-96-5
Chemical Structure
SBC-115076
- CAS No.: 489415-96-5
- Formula:C31H33N3O5
- Molecular Weight:527.61
IUPAC Name: 4-(4-(benzyloxy)-3-methylbenzoyl)-3-hydroxy-1-(3-morpholinopropyl)-5-(pyridin-4-yl)-1,5-dihydro-2H-pyrrol-2-one
InChIKey: UNINQWCCZAGYSH-UHFFFAOYSA-N
SMILES: O=C1N(CCCN2CCOCC2)C(C3=CC=NC=C3)C(C(C4=CC=C(OCC5=CC=CC=C5)C(C)=C4)=O)=C1O
Biological Activity: SBC-115076 is a potent proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitor. PCSK9 is a proprotein convertase, which plays a crucial role in LDL receptor metabolism[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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SBC-115076 | 99.28% | SBC-115076 is a potent proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitor. PCSK9 is a proprotein convertase, which plays a crucial role in LDL receptor metabolism. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.62
HY-W340839p53-MDM2-IN-1 -
Similarity Score 0.62
HY-W340313p53-MDM2-IN-4 -
Similarity Score 0.57
HY-129886PKUMDL-LTQ-301 -
Similarity Score 0.50
HY-117734PYD-106 -
Similarity Score 0.47
HY-146118P-gp modulator 3 -
Similarity Score 0.47
HY-149084LTB4 antagonist 3 -
Similarity Score 0.46
HY-170895Hsp90-IN-38 -
Similarity Score 0.46
HY-101291Iberdomide -
Similarity Score 0.46
HY-170910Hsp90-IN-39 -
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References
- [1]. Chanisa Thonusin, et al. The comparative effects of high dose atorvastatin and proprotein convertase subtilisin/kexin type 9 inhibitor on the mitochondria of oxidative muscle fibers in obese-insulin resistant female rats. Toxicol Appl Pharmacol. 2019 Nov 1;382:114741. [Content Brief]
- [2]. Wiciński M, et al. PCSK9 signaling pathways and their potential importance in clinical practice. EPMA J. 2017;8(4):391-402. Published 2017 Aug 14. [Content Brief]
