2. Ligand for E3 Ligase
  3. Iberdomide

Iberdomide (Synonyms: CC-220)

Cat. No.: HY-101291 Purity: 98.90%
Handling Instructions

Iberdomide (CC-220) is a cereblon (CRBN) modulator with an IC50 of 60 nM.

For research use only. We do not sell to patients.

Iberdomide Chemical Structure

Iberdomide Chemical Structure

CAS No. : 1323403-33-3

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 119 In-stock
Estimated Time of Arrival: December 31
2 mg USD 70 In-stock
Estimated Time of Arrival: December 31
5 mg USD 120 In-stock
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10 mg USD 210 In-stock
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25 mg USD 420 In-stock
Estimated Time of Arrival: December 31
50 mg USD 750 In-stock
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100 mg USD 1188 In-stock
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Based on 2 publication(s) in Google Scholar

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Iberdomide (CC-220) is a cereblon (CRBN) modulator with an IC50 of 60 nM.

In Vitro

Iberdomide contains a glutarimide ring that binds in the try-tryptophan pocket of cereblon and an isoindolinone ring that can interact with both cereblon and substrates. Treatment with Iberdomide results in the loss of Ikaros and Aiolos protein levels with EC50s of 1 nM and 0.5 nM [1].

In Vivo

Iberdomide (CC-220) is currently in phase 2 clinical trials for the treatment of systematic lupus erythematosus (SLE) and phase 1b/2a clinical trials for relapsed and refractory multiple myeloma (MM)[1].

Clinical Trial
Molecular Weight







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Room temperature in continental US; may vary elsewhere.

Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 30 mg/mL (66.74 mM)

*"≥" means soluble, but saturation unknown.

Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2247 mL 11.1235 mL 22.2469 mL
5 mM 0.4449 mL 2.2247 mL 4.4494 mL
10 mM 0.2225 mL 1.1123 mL 2.2247 mL
*Please refer to the solubility information to select the appropriate solvent.
Kinase Assay

Iberdomide is dissolved in DMSO. In the assay, 60 nM 6Xhis-tagged CRBN-DDB1 is combined with 30 nM cy5-conjugated cereblon modulator and 3 nM LanthaScreen Eu-anti-His Tag antibody in 20 mM HEPES pH 7, 150 mM NaCl, 0.005% Tween-20 assay buffer. FRET is observed by exciting at 340 nm and monitoring emission at 615 nm and 665 nm, and FRET efficiency is determined by the ratio of FRET to non-FRET emission. Competing cereblon modulating compound (Iberdomide) or DMSO carrier is titrated and incubated for 10 min before scanning[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.


Purity: 98.90%

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