MeIm
MeIm (compound 7) is a high-affinity PCSK9 targeting peptide mimetic with cholesterol-lowering activity. MeIm increases cellular uptake of LDL (EC50=6.04 μM) by inhibiting the binding of PCSK9 to LDLR (IC50=11.2 μM). MeIm can be used in the study of cardiovascular diseases.
For research use only. We do not sell to patients.
- CAS No.: 2043947-71-1
- Formula: C22H22N8
- Molecular Weight:398.46
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HepG2 | EC50 |
6 μM
Compound: 1; MeIm
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Inhibition of PCSK9 (unknown origin) interaction with LDLR expressed in human HepG2 cells assessed as increase in LDL uptake level measured after 24 hrs by LDL-Dylight 550 dye based fluorescence assay
Inhibition of PCSK9 (unknown origin) interaction with LDLR expressed in human HepG2 cells assessed as increase in LDL uptake level measured after 24 hrs by LDL-Dylight 550 dye based fluorescence assay
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[PMID: 31260298] |
Chemical Information
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CAS No. 2043947-71-1
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Molecular Weight 398.46
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Formula C22H22N8
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SMILES
CN1C(C2=CC=CC=C2)=CN=C1C3=CN=C(C4=CN=C(C5=CN=CN5C)N4C)N3C
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Xuhui Bao, et al. "Targeting proprotein convertase subtilisin/kexin type 9 (PCSK9): from bench to bedside." Signal Transduction and Targeted Therapy 9.1 (2024): 13. [Content Brief]
[2]. Stucchi, et al. "Disrupting the PCSK9/LDLR protein–protein interaction by an imidazole-based minimalist peptidomimetic." Organic & Biomolecular Chemistry 14.41 (2016): 9736-9740. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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