2043947-71-1
2043947-71-1
Chemical Structure
MeIm
- CAS No.: 2043947-71-1
- Formula:C22H22N8
- Molecular Weight:398.46
InChIKey: JYKZQFAVSJPBQM-UHFFFAOYSA-N
SMILES: CN1C(C2=CC=CC=C2)=CN=C1C3=CN=C(C4=CN=C(C5=CN=CN5C)N4C)N3C
Biological Activity: MeIm (compound 7) is a high-affinity PCSK9 targeting peptide mimetic with cholesterol-lowering activity. MeIm increases cellular uptake of LDL (EC50=6.04 μM) by inhibiting the binding of PCSK9 to LDLR (IC50=11.2 μM). MeIm can be used in the study of cardiovascular diseases[1][2].
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MeIm | MeIm (compound 7) is a high-affinity PCSK9 targeting peptide mimetic with cholesterol-lowering activity. MeIm increases cellular uptake of LDL (EC50=6.04 μM) by inhibiting the binding of PCSK9 to LDLR (IC50=11.2 μM). MeIm can be used in the study of cardiovascular diseases. | |||||||||||||||||||||
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References
- [1]. Xuhui Bao, et al. "Targeting proprotein convertase subtilisin/kexin type 9 (PCSK9): from bench to bedside." Signal Transduction and Targeted Therapy 9.1 (2024): 13. [Content Brief]
- [2]. Stucchi, et al. "Disrupting the PCSK9/LDLR protein–protein interaction by an imidazole-based minimalist peptidomimetic." Organic & Biomolecular Chemistry 14.41 (2016): 9736-9740. [Content Brief]
Keywords
