PF-06815345 hydrochloride
Based on 1 Customer Validation
PF-06815345 hydrochloride is an orally active and potent inhibitor of proprotein convertase subtilisin/kexin type 9 (PCSK9) with an IC50 value of 13.4 μM. PF-06815345 hydrochloride significantly decreases the PCSK9 level in vivo in mouse.
For research use only. We do not sell to patients.
- Purity: 98.15%
- CAS No.: 2334434-49-8
- Formula: C27H30Cl2FN9O4
- Molecular Weight:634.49
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Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
PF-06815345 hydrochloride (Example 7) (1-30 μM; 5-1440 min) in human enterocyte and hepatocyte with CLint values of <82.9 μL/min/mg and 97.6 μL/min/mg, respectively[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 2334434-49-8
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Appearance Solid
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Molecular Weight 634.49
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Formula C27H30Cl2FN9O4
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Color White to off-white
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SMILES
O=C(N([C@H]1CNCCC1)C2=C(Cl)C=CC=N2)C3=CC=C(C4=C(C5=NN=NN5[C@H](C)OC(OCC)=O)N(C)N=C4)C(F)=C3.[H]Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
DMSO : 50 mg/mL (78.80 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (281 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.5761 mL | 7.8803 mL | 15.7607 mL | 39.4017 mL |
| 5 mM | 0.3152 mL | 1.5761 mL | 3.1521 mL | 7.8803 mL | |
| 10 mM | 0.1576 mL | 0.7880 mL | 1.5761 mL | 3.9402 mL | |
| 15 mM | 0.1051 mL | 0.5254 mL | 1.0507 mL | 2.6268 mL | |
| 20 mM | 0.0788 mL | 0.3940 mL | 0.7880 mL | 1.9701 mL | |
| 25 mM | 0.0630 mL | 0.3152 mL | 0.6304 mL | 1.5761 mL | |
| 30 mM | 0.0525 mL | 0.2627 mL | 0.5254 mL | 1.3134 mL | |
| 40 mM | 0.0394 mL | 0.1970 mL | 0.3940 mL | 0.9850 mL | |
| 50 mM | 0.0315 mL | 0.1576 mL | 0.3152 mL | 0.7880 mL | |
| 60 mM | 0.0263 mL | 0.1313 mL | 0.2627 mL | 0.6567 mL |
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