2. Metabolic Enzyme/Protease
  3. Ser/Thr Protease
  4. PF-06815345 hydrochloride

PF-06815345 hydrochloride is an orally active and potent inhibitor of proprotein convertase subtilisin/kexin type 9 (PCSK9) with an IC50 value of 13.4 μM. PF-06815345 hydrochloride significantly decreases the PCSK9 level in vivo in mouse.

For research use only. We do not sell to patients.

PF-06815345 hydrochloride Chemical Structure

PF-06815345 hydrochloride Chemical Structure

CAS No. : 2334434-49-8

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5 mg USD 580 In-stock
10 mg USD 980 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of PF-06815345 hydrochloride:

PF-06815345 hydrochloride Related Antibodies

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  • Purity & Documentation

  • References

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Description

PF-06815345 hydrochloride is an orally active and potent inhibitor of proprotein convertase subtilisin/kexin type 9 (PCSK9) with an IC50 value of 13.4 μM. PF-06815345 hydrochloride significantly decreases the PCSK9 level in vivo in mouse[1][2].

In Vitro

PF-06815345 hydrochloride (Example 7) (1-30 μM; 5-1440 min) in human enterocyte and hepatocyte with CLint values of <82.9 μL/min/mg and 97.6 μL/min/mg, respectively[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

PF-06815345 hydrochloride Related Antibodies
In Vivo

PF-06815345 hydrochloride (Example 7) (100-500 mg/kg; p.o; single dose) lowers the level of PCSK9 in humanized PCSK9 mouse model. It lowers plasma PCSK9 to 72% at 500 mg/kg 4 hr later treatment[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
Molecular Weight

634.49

Formula

C27H30Cl2FN9O4
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(N([C@H]1CNCCC1)C2=C(Cl)C=CC=N2)C3=CC=C(C4=C(C5=NN=NN5[C@H](C)OC(OCC)=O)N(C)N=C4)C(F)=C3.[H]Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (78.80 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.5761 mL 7.8803 mL 15.7607 mL
5 mM 0.3152 mL 1.5761 mL 3.1521 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

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g

Dosing volume
(per animal)

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.5761 mL 7.8803 mL 15.7607 mL 39.4017 mL
5 mM 0.3152 mL 1.5761 mL 3.1521 mL 7.8803 mL
10 mM 0.1576 mL 0.7880 mL 1.5761 mL 3.9402 mL
15 mM 0.1051 mL 0.5254 mL 1.0507 mL 2.6268 mL
20 mM 0.0788 mL 0.3940 mL 0.7880 mL 1.9701 mL
25 mM 0.0630 mL 0.3152 mL 0.6304 mL 1.5761 mL
30 mM 0.0525 mL 0.2627 mL 0.5254 mL 1.3134 mL
40 mM 0.0394 mL 0.1970 mL 0.3940 mL 0.9850 mL
50 mM 0.0315 mL 0.1576 mL 0.3152 mL 0.7880 mL
60 mM 0.0263 mL 0.1313 mL 0.2627 mL 0.6567 mL
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PF-06815345 hydrochloride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PF-068153452334434-49-8PF06815345PF 06815345Ser/Thr ProteaseSerine proteasesSerine endopeptidasesThreonine proteasesInhibitorinhibitorinhibit

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PF-06815345 hydrochloride
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