Pep2-8 analogue 18
Pep2-8 analogue 18 is a high affinity PCSK9 (KD = 6 nM) inhibitory peptide. Pep2-8 analogue 18 restores LDL uptake in HepG2 cells (EC50 = 175 nM). Pep2-8 analogue 18 has good cellular safety. Pep2-8 analogue 18 can be used for research on cardiovascular conditions.
For research use only. We do not sell to patients.
- Formula: C124H190N32O25
- Molecular Weight:2529.03
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HepG2 | EC50 |
0.175 μM
Compound: 18
|
Reversal of LDL uptake in human HepG2 cells for 2 hrs preincubation with PCSK9 followed by LDL addition and measured after 4 hrs by fluorimetry method relative to control
Reversal of LDL uptake in human HepG2 cells for 2 hrs preincubation with PCSK9 followed by LDL addition and measured after 4 hrs by fluorimetry method relative to control
|
[PMID: 34266235] |
| LAD2 | EC50 |
2.2 μM
Compound: 18
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Effect on mast cell degranulation in human LAD2 cells assessed as CCL3 release measured after 2 hrs by Luminex bead based assay
Effect on mast cell degranulation in human LAD2 cells assessed as CCL3 release measured after 2 hrs by Luminex bead based assay
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[PMID: 34266235] |
Chemical Information
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Molecular Weight 2529.03
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Formula C124H190N32O25
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Sequence
Ac-His-Val-Phe-Lys-Ser-Trp-cyclo(Lys-Glu-Tyr-Leu-Asp)-Trp-Val-Lys-Lys-Lys-Lys-Lys-Lys-NH2
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Sequence Shortening
Ac-HVFKSW-cyclo(KEYLD)-WVKKKKKK-NH2
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Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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