1. Metabolic Enzyme/Protease
  2. Ser/Thr Protease
  3. SBC-115337

SBC-115337 

Cat. No.: HY-141714
Handling Instructions

SBC-115337, as a potent benzofuran compound, is a PCSK9 inhibitor with an IC50 value of 0.5 μM.

For research use only. We do not sell to patients.

SBC-115337 Chemical Structure

SBC-115337 Chemical Structure

CAS No. : 423148-46-3

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Description

SBC-115337, as a potent benzofuran compound, is a PCSK9 inhibitor with an IC50 value of 0.5 μM[1][2].

IC50 & Target

IC50: 0.5 μM (PCSK9)[1]

In Vitro

The potent compound (SBC-115,337) shows an IC50 of 0.6 μM measured in an in vitro ELISA assay to monitor the effect of PCSK9 binding to the recombinant LDLR. SBC-115,337 at 1.2 μM induces more than tenfold upregulation of LDLR in HepG2 cells with respect to the control, increases uptake of fluorescently labeled DiI-LDL and loweres LDL-c levels in mice fed a high-fat diet[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

473.48

Formula

C₂₉H₁₉N₃O₄

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Product Name:
SBC-115337
Cat. No.:
HY-141714
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