PCSK9 modulator-3
PCSK9 modulator-3 is a PCSK9 modulator that reduces the secretion level of PCSK9 protein in HepG2 cells. PCSK9 modulator-3 exhibits metabolic stability in liver microsomes of mice and rats. PCSK9 modulator-3 can be used for the study of hyperlipidemia.
For research use only. We do not sell to patients.
- CAS No.: 2476490-18-1
- Formula: C16H9F2N3O
- Molecular Weight:297.26
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
Description
In Vitro
PCSK9 modulator-3 (compound 13) (1-10 μM; 48 h) reduces the level of secreted PCSK9 protein in HepG2 cells by nearly 90%[1].
PCSK9 modulator-3 exhibits a T1/2 of 30.0 min and a CLint of 46.5 µL/min/mg in mouse liver microsomes, and a T1/2 of 47.8 min and a CLint of 29.4 µL/min/mg in rat liver microsomes[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Parmacokinetics
| Species | Dose | Route | AUC0-∞ | Cmax | T1/2 |
|---|---|---|---|---|---|
| Mice[1] | 6.0 mg/kg | i.p. | 695.6 μg/L·h | 294.3 μg/L | 1.64 h |
Chemical Information
-
CAS No. 2476490-18-1
-
Molecular Weight 297.26
-
Formula C16H9F2N3O
-
SMILES
O=C(C1=NC2=CC=C(F)C=C2N1)C3=CNC4=C3C=CC=C4F
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
PCSK9 modulator-3 Related Classifications
HY-146084 Related Classifications
Powered by Bioz