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Cat. No.: HY-161938

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BRD8518

BRD8518 is a PCSK9 inhibitor (EC₅₀=0.23 μM). BRD8518 lowers blood lipids by upregulating LDLR expression and stimulating LDL uptake. BRD8518 can be used in the study of cardiovascular diseases.

For research use only. We do not sell to patients.

CAS No.: 1565828-01-4
Formula: C₃₃H₃₂F₃N₃O₅
Molecular Weight:607.62

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

BRD8518 Chemical Structure

CAS No.: 1565828-01-4

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Bioz

Biological Activity

Description

Cellular Effect

Cell Line	Type	Value	Description	References
HepG2	EC₅₀	0.23 μM Compound: 1; BRD8518	Induction of TRIB1 expression in human HepG2 cells measured after overnight incubation by qRT-PCR analysis Induction of TRIB1 expression in human HepG2 cells measured after overnight incubation by qRT-PCR analysis	[PMID: 30542533]
HepG2	EC₅₀	0.24 μM Compound: 1; BRD8518	Down regulation of PCSK9 gene expression in human HepG2 cells measured after 24 hrs by qRT-PCR analysis Down regulation of PCSK9 gene expression in human HepG2 cells measured after 24 hrs by qRT-PCR analysis	[PMID: 30542533]
HepG2	EC₅₀	0.36 μM Compound: 77	Inhibition of PCSK9 mRNA expression in human HepG2 cells after 24 hrs by qRT-PCR analysis Inhibition of PCSK9 mRNA expression in human HepG2 cells after 24 hrs by qRT-PCR analysis	[PMID: 30448414]
HepG2	EC₅₀	0.43 μM Compound: 1; BRD8518	Up regulation of TRIB1 gene expression in human HepG2 cells measured after 6 hrs by qRT-PCR analysis Up regulation of TRIB1 gene expression in human HepG2 cells measured after 6 hrs by qRT-PCR analysis	[PMID: 30542533]
HepG2	EC₅₀	0.49 μM Compound: 1; BRD8518	Up regulation of LDLR gene expression in human HepG2 cells measured after 6 hrs by qRT-PCR analysis Up regulation of LDLR gene expression in human HepG2 cells measured after 6 hrs by qRT-PCR analysis	[PMID: 30542533]

Chemical Information

CAS No. 1565828-01-4
Molecular Weight 607.62
Formula C₃₃H₃₂F₃N₃O₅
SMILES

O=C(NC1=CC=C2C(C(N(C)[C@H]3CC[C@@H](CC(NC4CC(C=CC=C5)=C5C4)=O)O[C@H]3CO2)=O)=C1)C6=CC=C(C(F)(F)F)C=C6
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Xuhui Bao, et al. "Targeting proprotein convertase subtilisin/kexin type 9 (PCSK9): from bench to bedside." Signal Transduction and Targeted Therapy 9.1 (2024): 13. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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