1. GPCR/G Protein
    Immunology/Inflammation
  2. CXCR
    Interleukin Related
  3. Elubrixin tosylate

Elubrixin tosylate (Synonyms: SB-656933 tosylate)

Cat. No.: HY-18263C Purity: 99.74%
Handling Instructions

Elubrixin tosylate (SB-656933 tosylate) is a potent, selective, competitive, reversible and orally active CXCR2 antagonist and an IL-8 receptor antagonist. Elubrixin tosylate inhibits neutrophil CD11b upregulation (IC50 of 260.7 nM) and shape change (IC50 of 310.5 nM). Elubrixin tosylate has the potential for inflammatory diseases research, such as inflammatory bowel disease and airway inflammation.

For research use only. We do not sell to patients.

Elubrixin tosylate Chemical Structure

Elubrixin tosylate Chemical Structure

CAS No. : 960495-43-6

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10 mM * 1  mL in DMSO USD 419 In-stock
Estimated Time of Arrival: December 31
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25 mg USD 950 In-stock
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50 mg USD 1500 In-stock
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100 mg USD 2400 In-stock
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Description

Elubrixin tosylate (SB-656933 tosylate) is a potent, selective, competitive, reversible and orally active CXCR2 antagonist and an IL-8 receptor antagonist. Elubrixin tosylate inhibits neutrophil CD11b upregulation (IC50 of 260.7 nM) and shape change (IC50 of 310.5 nM). Elubrixin tosylate has the potential for inflammatory diseases research, such as inflammatory bowel disease and airway inflammation[1][2][3].

IC50 & Target[1][2]

CXCR2

 

IL-8

 

In Vitro

Elubrixin has an inhibitory effect on neutrophils in a dose-dependent fashion[1].

Molecular Weight

635.51

Formula

C₂₄H₂₅Cl₂FN₄O₇S₂

CAS No.

960495-43-6

SMILES

O=C(NC1=CC=C(Cl)C(S(=O)(N2CCNCC2)=O)=C1O)NC3=CC=CC(F)=C3Cl.OS(=O)(C4=CC=C(C)C=C4)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
References
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Keywords:

ElubrixinSB-656933SB656933SB 656933CXCRInterleukin RelatedCXC chemokine receptorsC-X-C motif chemokine receptorsILIL-8CXCR2neutrophil-mediatedCD11bairwayanti-inflammatorybowelInhibitorinhibitorinhibit

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Elubrixin tosylate
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HY-18263C
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