1. GPCR/G Protein
    Immunology/Inflammation
  2. CXCR
    Interleukin Related
  3. Elubrixin

Elubrixin (Synonyms: SB-656933)

Cat. No.: HY-18263A
Handling Instructions

Elubrixin (SB-656933) is a potent, selective, competitive, reversible and orally active CXCR2 antagonist and an IL-8 receptor antagonist. Elubrixin inhibits neutrophil CD11b upregulation (IC50 of 260.7 nM) and shape change (IC50 of 310.5 nM). Elubrixin has the potential for inflammatory diseases research, such as inflammatory bowel disease and airway inflammation.

For research use only. We do not sell to patients.

Elubrixin Chemical Structure

Elubrixin Chemical Structure

CAS No. : 688763-64-6

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Description

Elubrixin (SB-656933) is a potent, selective, competitive, reversible and orally active CXCR2 antagonist and an IL-8 receptor antagonist. Elubrixin inhibits neutrophil CD11b upregulation (IC50 of 260.7 nM) and shape change (IC50 of 310.5 nM). Elubrixin has the potential for inflammatory diseases research, such as inflammatory bowel disease and airway inflammation[1][2][3].

IC50 & Target[1][2]

CXCR2

 

IL-8

 

In Vitro

Elubrixin has an inhibitory effect on neutrophils in a dose-dependent fashion[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial
Molecular Weight

463.31

Formula

C17H17Cl2FN4O4S

CAS No.
SMILES

O=C(NC1=CC=C(Cl)C(S(=O)(N2CCNCC2)=O)=C1O)NC3=CC=CC(F)=C3Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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Elubrixin
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