2. Immunology/Inflammation
  3. COX
  4. Metyrosine

Metyrosine 

Cat. No.: HY-W015007 Purity: ≥98.0%
COA Handling Instructions

Metyrosine is a selective tyrosine hydroxylase enzyme inhibitor. Metyrosine exerts anti-inflammatory and anti-ulcerative effects. Metyrosine significantly inhibits high COX-2 activity. Metyrosine is a very effective agent for blood pressure control.

For research use only. We do not sell to patients.

Metyrosine Chemical Structure

Metyrosine Chemical Structure

CAS No. : 672-87-7

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50 mg USD 70 In-stock
100 mg USD 100 In-stock
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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Metyrosine:

Metyrosine Related Antibodies

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Description

Metyrosine is a selective tyrosine hydroxylase enzyme inhibitor. Metyrosine exerts anti-inflammatory and anti-ulcerative effects. Metyrosine significantly inhibits high COX-2 activity[1]. Metyrosine is a very effective agent for blood pressure control[2].

In Vitro

Metyrosine acts by inhibiting tyrosine hydroxylase, thus causing depletion of adrenal stores of catecholamines[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Metyrosine Related Antibodies
In Vivo

Metyrosine (50-200 mg/kg; i.p.) reduces carrageenan inflammation[1].
Metyrosine (50-200 mg/kg; i.p.) shows antiulcerative activity is 87.7%, 93.7% and 95.5% for 50, 100 and 200 mg/kg doses of metyrosine, respectively[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male albino Wistar rats (carrageenan-induced rat paw edema)[2]
Dosage: 50, 100 or 200 mg/kg
Administration: I.p.
Result: Reduced carrageenan inflammation at 50, 100 and 200 mg/kg doses (40%, 67% and 87%, respectively, at 4 h).
Clinical Trial
Molecular Weight

195.22

Appearance

Solid

Formula

C10H13NO3
CAS No.
SMILES

C[C@](C(O)=O)(N)CC1=CC=C(O)C=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

H2O : 5 mg/mL (25.61 mM; ultrasonic and warming and adjust pH to 2 with HCl and heat to 60°C)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 5.1224 mL 25.6121 mL 51.2243 mL
5 mM 1.0245 mL 5.1224 mL 10.2449 mL
10 mM 0.5122 mL 2.5612 mL 5.1224 mL
*Please refer to the solubility information to select the appropriate solvent.
Purity & Documentation

Purity: ≥98.0%

COA (246 KB) HNMR (256 KB) MS (75 KB)

Handling Instructions (2659 KB)
References
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Metyrosine Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

Metyrosine672-87-7COXCyclooxygenasegastricanti-ulcerativeCOX-2inflammationcatecholaminesynthesisbloodpressureInhibitorinhibitorinhibit

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