1. Immunology/Inflammation
  2. COX
  3. Metyrosine

Metyrosine 

Cat. No.: HY-W015007 Purity: 98.79%
Handling Instructions

Metyrosine is a selective tyrosine hydroxylase enzyme inhibitor. Metyrosine exerts anti-inflammatory and anti-ulcerative effects. Metyrosine significantly inhibits high COX-2 activity. Metyrosine is a very effective agent for blood pressure control.

For research use only. We do not sell to patients.

Metyrosine Chemical Structure

Metyrosine Chemical Structure

CAS No. : 672-87-7

Size Price Stock Quantity
25 mg USD 150 In-stock
Estimated Time of Arrival: December 31
50 mg USD 240 In-stock
Estimated Time of Arrival: December 31
100 mg USD 380 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

Metyrosine is a selective tyrosine hydroxylase enzyme inhibitor. Metyrosine exerts anti-inflammatory and anti-ulcerative effects. Metyrosine significantly inhibits high COX-2 activity[1]. Metyrosine is a very effective agent for blood pressure control[2].

In Vitro

Metyrosine acts by inhibiting tyrosine hydroxylase, thus causing depletion of adrenal stores of catecholamines[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Metyrosine (50-200 mg/kg; i.p.) reduces carrageenan inflammation[1].
Metyrosine (50-200 mg/kg; i.p.) shows antiulcerative activity is 87.7%, 93.7% and 95.5% for 50, 100 and 200 mg/kg doses of metyrosine, respectively[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male albino Wistar rats (carrageenan-induced rat paw edema)[2]
Dosage: 50, 100 or 200 mg/kg
Administration: I.p.
Result: Reduced carrageenan inflammation at 50, 100 and 200 mg/kg doses (40%, 67% and 87%, respectively, at 4 h).
Clinical Trial
Molecular Weight

195.22

Formula

C₁₀H₁₃NO₃

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : 5 mg/mL (25.61 mM; ultrasonic and warming and adjust pH to 2 with HCl and heat to 60°C)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 5.1224 mL 25.6121 mL 51.2243 mL
5 mM 1.0245 mL 5.1224 mL 10.2449 mL
10 mM 0.5122 mL 2.5612 mL 5.1224 mL
*Please refer to the solubility information to select the appropriate solvent.
References

Purity: 98.79%

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Product Name:
Metyrosine
Cat. No.:
HY-W015007
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