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  3. Metyrosine

Metyrosine 

Cat. No.: HY-W015007 Purity: 98.79%
Handling Instructions

Metyrosine is a selective tyrosine hydroxylase enzyme inhibitor. Metyrosine exerts anti-inflammatory and anti-ulcerative effects. Metyrosine significantly inhibits high COX-2 activity. Metyrosine is a very effective agent for blood pressure control.

For research use only. We do not sell to patients.

Metyrosine Chemical Structure

Metyrosine Chemical Structure

CAS No. : 672-87-7

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 165 In-stock
Estimated Time of Arrival: December 31
25 mg USD 150 In-stock
Estimated Time of Arrival: December 31
50 mg USD 240 In-stock
Estimated Time of Arrival: December 31
100 mg USD 380 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

Metyrosine is a selective tyrosine hydroxylase enzyme inhibitor. Metyrosine exerts anti-inflammatory and anti-ulcerative effects. Metyrosine significantly inhibits high COX-2 activity[1]. Metyrosine is a very effective agent for blood pressure control[2].

In Vitro

Metyrosine acts by inhibiting tyrosine hydroxylase, thus causing depletion of adrenal stores of catecholamines[2].

In Vivo

Metyrosine (50-200 mg/kg; i.p.) reduces carrageenan inflammation[1].
Metyrosine (50-200 mg/kg; i.p.) shows antiulcerative activity is 87.7%, 93.7% and 95.5% for 50, 100 and 200 mg/kg doses of metyrosine, respectively[1].

Animal Model: Male albino Wistar rats (carrageenan-induced rat paw edema)[2]
Dosage: 50, 100 or 200 mg/kg
Administration: I.p.
Result: Reduced carrageenan inflammation at 50, 100 and 200 mg/kg doses (40%, 67% and 87%, respectively, at 4 h).
Molecular Weight

195.22

Formula

C₁₀H₁₃NO₃

CAS No.

672-87-7

SMILES

C[[email protected]](C(O)=O)(N)CC1=CC=C(O)C=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
References
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Keywords:

MetyrosineCOXCyclooxygenasegastricanti-ulcerativeCOX-2inflammationcatecholaminesynthesisbloodpressureInhibitorinhibitorinhibit

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Metyrosine
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HY-W015007
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