p-Coumaric acid
Based on 5 publication(s) in Google Scholar
p-Coumaric acid (trans-4-Hydroxycinnamic acid) is an isomer of cinnamic acid with oral activity. p-Coumaric acid inhibits cell proliferation and promotes apoptosis. p-Coumaric acid has antibacterial, anti-inflammatory, antioxidant and anti-tumor activities.
연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.
- Purity: 99.90%
- CAS No.: 501-98-4
- 화학식: C9H8O3
- 분자량:164.16
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보관:
RT, stored under nitrogen.
In solvent -80°C, 1 year , -20°C, 6 months
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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용액&용해도
- 순도&문서
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) p-Coumaric acid
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Customer Validation & Images
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Histological Imaging/Staining
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Bio/Physico-chemical Assay
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Histological Imaging/Staining
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ELISA
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WB
All Endogenous Metabolite Isoforms
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Biological Activity
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Microbial Metabolite |
Human Endogenous Metabolite |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
>100 μM
Compound: 14
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Cytotoxicity against human A549 cells after 72 hrs by MTT assay
Cytotoxicity against human A549 cells after 72 hrs by MTT assay
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[PMID: 21696954] |
| A549 | IC50 |
>10 μM
Compound: 6
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Cytotoxicity against human A549 cells after 48 hrs by SRB assay
Cytotoxicity against human A549 cells after 48 hrs by SRB assay
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[PMID: 27700070] |
| B16-F10 | IC50 |
>10 μM
Compound: PCA
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Cytotoxicity against mouse B16-F10 cells assessed as cell growth inhibition measured after 72 hrs by MTT assay
Cytotoxicity against mouse B16-F10 cells assessed as cell growth inhibition measured after 72 hrs by MTT assay
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[PMID: 33956447] |
| BT-549 | IC50 |
10 μM
Compound: 6
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Cytotoxicity against human BT549 cells after 48 hrs by SRB assay
Cytotoxicity against human BT549 cells after 48 hrs by SRB assay
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[PMID: 27700070] |
| BV-2 | IC50 |
>50 μM
Compound: 6
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Antineuroinflammatory activity in mouse BV2 cells assessed as inhibition of LPS-induced nitric oxide production after 24 hrs by Griess assay
Antineuroinflammatory activity in mouse BV2 cells assessed as inhibition of LPS-induced nitric oxide production after 24 hrs by Griess assay
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[PMID: 27700070] |
| BV-2 | IC50 |
>100 μM
Compound: 23
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Antineuroinflammatory activity in mouse BV2 cells assessed as inhibition of LPS-induced NO production after 24 hrs in presence of LPS by Griess reaction based assay
Antineuroinflammatory activity in mouse BV2 cells assessed as inhibition of LPS-induced NO production after 24 hrs in presence of LPS by Griess reaction based assay
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[PMID: 28911817] |
| HepG2 | IC50 |
>10 μM
Compound: PCA
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Cytotoxicity against human HepG2 cells assessed as cell growth inhibition measured after 72 hrs by MTT assay
Cytotoxicity against human HepG2 cells assessed as cell growth inhibition measured after 72 hrs by MTT assay
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[PMID: 33956447] |
| HT-1080 | ED50 |
>100 μM
Compound: 18
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Antiproliferative activity against human HT1080 cells by MTT assay
Antiproliferative activity against human HT1080 cells by MTT assay
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[PMID: 11277741] |
| HT-22 | EC50 |
6.4 μM
Compound: 29
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Neuroprotective activity against glutamate-induced cell death in mouse HT-22 cells assessed as increase in cell viability after 24 hrs by EZ-Cytox assay
Neuroprotective activity against glutamate-induced cell death in mouse HT-22 cells assessed as increase in cell viability after 24 hrs by EZ-Cytox assay
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[PMID: 32991171] |
| HT-29 | IC50 |
>10 μM
Compound: PCA
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Cytotoxicity against human HT-29 cells assessed as cell growth inhibition measured after 72 hrs by MTT assay
Cytotoxicity against human HT-29 cells assessed as cell growth inhibition measured after 72 hrs by MTT assay
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[PMID: 33956447] |
| KB | IC50 |
>200 μM
Compound: 1f
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Antitumor activity against KB cells by MTT assay
Antitumor activity against KB cells by MTT assay
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[PMID: 17387015] |
| LoVo | IC50 |
82 μM
Compound: 14
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Cytotoxicity against human LoVo cells after 72 hrs by MTT assay
Cytotoxicity against human LoVo cells after 72 hrs by MTT assay
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[PMID: 21696954] |
| Oocyte | IC50 |
9.59 μM
Compound: 4-OH-Cin-COOH
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Antagonist activity at Gloeobacter violaceus ligand-gated ion channel expressed in Xenopus oocytes assessed as inhibition of MES buffer pH 5.5 -induced currents after 30 secs by voltage clamp technique
Antagonist activity at Gloeobacter violaceus ligand-gated ion channel expressed in Xenopus oocytes assessed as inhibition of MES buffer pH 5.5 -induced currents after 30 secs by voltage clamp technique
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[PMID: 23682762] |
| PC-3 | IC50 |
>100 μM
Compound: 14
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Cytotoxicity against human PC3 cells after 72 hrs by MTT assay
Cytotoxicity against human PC3 cells after 72 hrs by MTT assay
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[PMID: 21696954] |
| Platelet | IC50 |
74.8 μM
Compound: 4-OH-cinnamic acid
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Anti-platelet activity in rabbit platelet-rich plasma assessed as inhibition of ADP-induced platelet aggregation incubated for 5 mins at 37 degC by aggregometry
Anti-platelet activity in rabbit platelet-rich plasma assessed as inhibition of ADP-induced platelet aggregation incubated for 5 mins at 37 degC by aggregometry
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10.1039/C4MD00022F |
| RAW264.7 | IC50 |
>50 μM
Compound: 11
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Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production after 24 hrs by Griess method
Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production after 24 hrs by Griess method
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[PMID: 22079762] |
| RAW264.7 | IC50 |
73.4 μM
Compound: 11
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Antiinflammatory activity in mouse RAW264.7 cells assessed as decrease in LPS-induced NO production after 24 hrs by Griess assay
Antiinflammatory activity in mouse RAW264.7 cells assessed as decrease in LPS-induced NO production after 24 hrs by Griess assay
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[PMID: 25666824] |
| RAW264.7 | GI50 |
4560 μM
Compound: 1a
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Cytotoxicity against mouse RAW264.7 cells assessed as growth inhibition after 48 hrs by trypan blue assay
Cytotoxicity against mouse RAW264.7 cells assessed as growth inhibition after 48 hrs by trypan blue assay
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10.1039/C3MD00251A |
| SK-MEL-2 | IC50 |
>10 μM
Compound: 6
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Cytotoxicity against human SK-MEL-2 cells after 48 hrs by SRB assay
Cytotoxicity against human SK-MEL-2 cells after 48 hrs by SRB assay
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[PMID: 27700070] |
| SK-MEL-28 | IC50 |
>100 μM
Compound: 14
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Cytotoxicity against human SK-MEL-28 cells after 72 hrs by MTT assay
Cytotoxicity against human SK-MEL-28 cells after 72 hrs by MTT assay
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[PMID: 21696954] |
| SK-OV-3 | IC50 |
>10 μM
Compound: 6
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Cytotoxicity against human SKOV3 cells after 48 hrs by SRB assay
Cytotoxicity against human SKOV3 cells after 48 hrs by SRB assay
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[PMID: 27700070] |
| U-373MG ATCC | IC50 |
>100 μM
Compound: 14
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Cytotoxicity against human U373 cells after 72 hrs by MTT assay
Cytotoxicity against human U373 cells after 72 hrs by MTT assay
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[PMID: 21696954] |
| U-937 | CC50 |
>2000 μM
Compound: 24, p-coumaric acid
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Cytotoxicity against human U937 cells after 48 hrs by trypan blue assay
Cytotoxicity against human U937 cells after 48 hrs by trypan blue assay
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[PMID: 22925447] |
| U-937 | IC50 |
>2000 μM
Compound: 24, p-coumaric acid
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Antiproliferative activity against human U937 cells assessed as incorporation of [3H]-methyl-thymidine after 12 hrs by scintillation counting
Antiproliferative activity against human U937 cells assessed as incorporation of [3H]-methyl-thymidine after 12 hrs by scintillation counting
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[PMID: 22925447] |
p-Coumaric acid (1 or 3 μg/mL, 24, 48, 72 h) can significantly inhibit the proliferation of human and mouse melanoma cells in vitro and promote cell apoptosis[1].
p-Coumaric acid (10-80 μg/mL) shows antibacterial activity against both gram-negative and Gram-positive bacteria, and MIC values for Escherichia coli, Streptococcus dysenteriae and Salmonella typhimurium are 80, 10 and 20 μg/ml[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:A375, B16
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Concentration:1.5, 2, 2.5, 3, 3.5, 4, 4.5, 5 mM
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Incubation Time:24, 48 h
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Result:Inhibited the proliferation of A375 and B16 cells The IC50 values on A375 cells were 4.4 mM and 2.5 mM , and the IC50 values on B16 cells were 4.1 mM and 2.8 mM in 24 and 48 h, respectively.
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Cell Line:A375, B16
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Concentration:1.5, 2.5, 3 mM;2, 3, 4 mM
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Incubation Time:24 h
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Result:Increased the S phase proportion in A375 cells and the G0/G1 phase proportion in B16 cells.
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Cell Line:A375, B16
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Concentration:1.5, 2.5, 3 mM;2, 3, 4 mM
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Incubation Time:24 h
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Result:Reduced the expression levels of CDK2 and Cyclin A in A375 cells and the levels of CDK2 and Cyclin E in B16 cells. Decreased the levels of caspase-3 and caspase-9 and increased the levels of cleaved caspase-3 and cleaved caspase-9. Downregulated Bcl-2 and upregulated Bax, Apaf1, and cytoplasmic Cyto-C levels.
p-Coumaric acid (15, 100 mg/kg, oral) alleviates nephrotoxicity induced by Doxorubicin (HY-15142A) in rats by inhibiting oxidative stress, inflammation and apoptosis[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:DMH-induced colonic preneoplastic lesions in rats[3]
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Dosage:50, 100, 200 mg/kg
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Administration:suspended in 0.5% carboxymethylcellulose (CMC) and administered every day via intragastric intubation
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Result:Reduced the polyp incidence to 71.42%, 57.14% and 42.85% respectively. Reduced the ACF and DACF in a dose-dependent manner and the β– catenin immune activity. Decreased levels of TBARS and increased levels of SOD, CAT and GPx. Decreased the activity of β-glucuronidase, and mucinase.
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Animal Model:Doxorubicin-induced nephrotoxicity rats[4]
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Dosage:15, 100 mg/kg
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Administration:p.o.
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Result:Decreased serum creatinine, BUN and lipid peroxidation, IL-1β and TNF-α. Decreased the number of TUNEL-positive cells.
Chemical Information
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CAS No. 501-98-4
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Appearance Solid
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분자량 164.16
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화학식 C9H8O3
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Color Off-white to light yellow
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SMILES
O=C(O)/C=C/C1=CC=C(O)C=C1
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Synonyms
trans-4-Hydroxycinnamic acid
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Structure Classification
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Initial Source
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선적
Room temperature in continental US; may vary elsewhere.
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보관
RT, stored under nitrogen
In solvent -80°C 1 year -20°C 6 months
Publications (5)
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Journal Impact Factor
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Most Recent
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Phytomedicine
Modified Fuzheng Yiliu Decoction chemosensitizes colorectal cancer by inhibiting cancer stem cell metabolism and stemness through CAV1/ZNF460/GRP78 signaling. [Abstract]2026 Jul 25:157:158317. PMID: 42177885 -
Food Chem
Discovery of novel ascorbic acid derivatives and other metabolites in fruit of Rosa roxburghii Tratt through untargeted metabolomics and feature-based molecular networking. [Abstract]2023 Mar 30;405(Pt A):134807. PMID: 36370576 -
p-Coumaric acid purchased from MedChemExpress. Usage Cited in: Food Biosci. 2024 Nov 28.
Serum glucose, AST, ALT, TG, and TCHO levels after 12 h of fasting in CHOW or DIO mice. p-Coumaric acid (p-CA, 30 and 100 mg/kg; i.g.; once daily for 12 weeks) significantly reduced blood glucose and NAFLD-related indicators, including AST, ALT, TG and TCHO, in mice induced by a high-fat diet (HFD).
p-Coumaric acid purchased from MedChemExpress. Usage Cited in: Food Biosci. 2024 Nov 28.
H&E and Oil Red O (ORO) staining images of the liver in 17-week-old male mice. Scale bar, 200 μm. Histological examination of the liver by H&E staining showed that numerous hepatocytes in the HFD control group presented with fatty degeneration, characterized by small, round vacuoles within the cytoplasm, accompanied by mild hydropic degeneration with swollen, loose, and pale-staining cytoplasm. Following p-Coumaric acid (p-CA, 30 and 100 mg/kg; i.g.; once daily for 12 weeks) administration, the lobular architecture of the liver was clearly defined and arranged regularly without apparent abnormalities.
p-Coumaric acid purchased from MedChemExpress. Usage Cited in: Food Biosci. 2024 Nov 28.
The concentration of GLP-1 in the culture medium of STC-1 cells and NCI-H716 cells was determined by ELISA. The results showed that p-Coumaric acid (p-CA, 400 μM; 5 h) effectively enhanced GLP-1 secretion in cells.
p-Coumaric acid purchased from MedChemExpress. Usage Cited in: Food Biosci. 2024 Nov 28.
Protein expression of GRP78 in the terminal ileum of the small intestine tissue was detected by Western blot. p-Coumaric acid (p-CA, 30 and 100 mg/kg; i.g.; once daily for 12 weeks; mice) resulted in a significant decrease of GRP78 protein expression compared to the HFD control group, with the high-dose group showing a better effect.
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Chem Biol Interact
Integrated multi-omics analysis reveals NRF2-dependent ferroptosis regulation underlying the renoprotective effects of p-coumaric acid in folic acid-induced AKI. [Abstract]2026 Jul 25:435:112114. PMID: 42092523 -
J Nutr Biochem
P-coumaric-acid ameliorates acute kidney injury induced by ischemia-reperfusion injury via suppressing ferroptosis. [Abstract]2025 Nov 7:149:110175. PMID: 41207539
p-Coumaric acid purchased from MedChemExpress. Usage Cited in: J Nutr Biochem. 2025 Nov 7:149:110175. [Abstract]
HE and Masson staining were used to assess the renal histological morphology and the degree of renal fibrosis in each group of mice. The results showed that p-Coumaric acid (p-CA, 25-100 mg/kg; i.g.; once daily for 2 weeks) significantly protected renal tissue in a mouse model of AKI induced by I/R.
용액&용해도
DMSO : 25 mg/mL (152.29 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
H2O : 1 mg/mL (6.09 mM; ultrasonic and warming and heat to 60°C)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.08 mg/mL (12.67 mM); Clear solution
This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.08 mg/mL (12.67 mM); Clear solution
This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
순도&문서
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Data Sheet (278 KB)
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SDS (396 KB)
- English - EN (396 KB)
- Français - FR (396 KB)
- Deutsch - DE (396 KB)
- Norwegian - NO (396 KB)
- Español - ES (396 KB)
- Swedish - SV (396 KB)
- Italian - IT (396 KB)
- Korean - KR (396 KB)
- Portuguese - PT (396 KB)
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Handling Instructions (2659 KB)
References
[1]. Hu X, et al. The Anti-tumor Effects of p-Coumaric Acid on Melanoma A375 and B16 Cells. Front Oncol. 2020 Oct 16;10:558414. [Content Brief]
[3]. Sharma SH, et al. Protective effect of p-coumaric acid against 1,2 dimethylhydrazine induced colonic preneoplastic lesions in experimental rats. Biomed Pharmacother. 2017 Oct;94:577-588. [Content Brief]
[4]. Rafiee Z, et al Doxorubicin-Induced Nephrotoxicity Through Suppression of Oxidative Stress, Inflammation and Apoptosis. Arch Med Res. 2020 Jan;51(1):32-40. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O / DMSO | 1 mM | 6.0916 mL | 30.4581 mL | 60.9162 mL | 152.2904 mL |
| 5 mM | 1.2183 mL | 6.0916 mL | 12.1832 mL | 30.4581 mL | |
| DMSO | 10 mM | 0.6092 mL | 3.0458 mL | 6.0916 mL | 15.2290 mL |
| 15 mM | 0.4061 mL | 2.0305 mL | 4.0611 mL | 10.1527 mL | |
| 20 mM | 0.3046 mL | 1.5229 mL | 3.0458 mL | 7.6145 mL | |
| 25 mM | 0.2437 mL | 1.2183 mL | 2.4366 mL | 6.0916 mL | |
| 30 mM | 0.2031 mL | 1.0153 mL | 2.0305 mL | 5.0763 mL | |
| 40 mM | 0.1523 mL | 0.7615 mL | 1.5229 mL | 3.8073 mL | |
| 50 mM | 0.1218 mL | 0.6092 mL | 1.2183 mL | 3.0458 mL | |
| 60 mM | 0.1015 mL | 0.5076 mL | 1.0153 mL | 2.5382 mL | |
| 80 mM | 0.0761 mL | 0.3807 mL | 0.7615 mL | 1.9036 mL | |
| 100 mM | 0.0609 mL | 0.3046 mL | 0.6092 mL | 1.5229 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
p-Coumaric acid Related Classifications
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