Constituents of the stem barks of Ailanthus altissima and their potential to inhibit LPS-induced nitric oxide production

  • Bioorg Med Chem Lett. 2015 Mar 1;25(5):1017-20. doi: 10.1016/j.bmcl.2015.01.034.
Hye Mi Kim  1 ,  Su Jung Kim  1 ,  Ha-Yeong Kim  2 ,  Byeol Ryu  2 ,  Hokwang Kwak  2 ,  Jonghyun Hur  3 ,  Jung-Hye Choi  4 ,  Dae Sik Jang  5
Affiliations
  • 1. College of Pharmacy, Kyung Hee University, Seoul 130-701, Republic of Korea.
  • 2. Department of Life & Nanopharmaceutical Science, Kyung Hee University, Seoul 130-701, Republic of Korea.
  • 3. Central Research Institute, Whan In Pharm Co., Ltd, Suwon 443-766, Republic of Korea.
  • 4. College of Pharmacy, Kyung Hee University, Seoul 130-701, Republic of Korea; Department of Life & Nanopharmaceutical Science, Kyung Hee University, Seoul 130-701, Republic of Korea.
  • 5. College of Pharmacy, Kyung Hee University, Seoul 130-701, Republic of Korea; Department of Life & Nanopharmaceutical Science, Kyung Hee University, Seoul 130-701, Republic of Korea. Electronic address: [email protected].
PMID: 25666824 DOI: 10.1016/j.bmcl.2015.01.034
Abstract

Three new canthinone type Alkaloids, canthin-6-one-1-O-β-D-apiofuranosyl-(1→2)-β-D-glucopyranoside (1), canthin-6-one-1-O-[6-O-(3-hydroxy-3-methylglutaryl)]-β-D-glucopyranoside (2) and canthin-6-one-1-O-[2-β-D-apiofuranosyl-6-O-(3-hydroxy-3-methylglutaryl)]-β-D-glucopyranoside (3) were isolated from the stem barks of Ailanthus altissima together with four quassinoids (4-7), seven Phenylpropanoids (8-14) and a lignan of previously known structure (15). The inflammatory activities of the 15 isolates were screened on LPS-induced nitric oxide (NO), a proinflammatory mediator, in RAW 264.7 cells.

Keywords
Ailanthus altissima; Canthinone type alkaloids; Inflammation; Nitric oxide; Simaroubaceae.