Wasabisides A-E, Lignan Glycosides from the Roots of Wasabia japonica

  • J Nat Prod. 2016 Oct 28;79(10):2652-2657. doi: 10.1021/acs.jnatprod.6b00582.
Chung Sub Kim  1 ,  Lalita Subedi  2  3 ,  Oh Wook Kwon  4 ,  Hyun Bong Park  5  6 ,  Sun Yeou Kim  2  3 ,  Sang Un Choi  7 ,  Kang Ro Lee  1
Affiliations
  • 1. Natural Products Laboratory, School of Pharmacy, Sungkyunkwan University , Suwon 16419, Republic of Korea.
  • 2. Gachon Institute of Pharmaceutical Science, Gachon University , Incheon 21936, Republic of Korea.
  • 3. College of Pharmacy, Gachon University , #191, Hambakmoero, Yeonsu-gu, Incheon 21936, Republic of Korea.
  • 4. Natural F&P Corp. , 152 Saemal-ro, Songpa-gu, Seoul 05802, Republic of Korea.
  • 5. Department of Chemistry, Yale University , New Haven, Connecticut 06520, United States.
  • 6. Chemical Biology Institute, Yale University , West Haven, Connecticut 06516, United States.
  • 7. Korea Research Institute of Chemical Technology , Daejeon 34114, Republic of Korea.
PMID: 27700070 DOI: 10.1021/acs.jnatprod.6b00582
Abstract

Five new lignan glycosides, wasabisides A-E (1-5), and four known phenolic compounds (6-9), were isolated from the roots of Wasabia japonica. The chemical structures of the new compounds (1-5) were determined through spectroscopic analysis and chemical methods. All isolated compounds (1-9) were evaluated for their potential neuroprotective effects through induction of nerve growth factor in C6 glioma cells, for their effects on nitric oxide levels in lipopolysaccharide-stimulated murine microglia BV2 cells, and for their cytotoxicity against four human tumor cell lines (A549, SK-OV-3, SK-MEL-2, and BT549).