1. Metabolic Enzyme/Protease
  2. Phosphodiesterase (PDE)
  3. Olprinone

Olprinone  (Synonyms: Loprinone)

Cat. No.: HY-14254A Purity: 99.29%
COA Handling Instructions

Olprinone (Loprinone) is a potent phosphodiesterase (PDE) 3 inhibitor, with IC50s of 150, 100, 0.35 and 14 μM for PDE1, PDE2, PDE3 and PDE4, respectively. Olprinone is used for the research of heart failure due to its positive inotropic and vasodilative effects. Anti-inflammatory activity.

For research use only. We do not sell to patients.

Olprinone Chemical Structure

Olprinone Chemical Structure

CAS No. : 106730-54-5

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Description

Olprinone (Loprinone) is a potent phosphodiesterase (PDE) 3 inhibitor, with IC50s of 150, 100, 0.35 and 14 μM for PDE1, PDE2, PDE3 and PDE4, respectively. Olprinone is used for the research of heart failure due to its positive inotropic and vasodilative effects. Anti-inflammatory activity[1][2].

IC50 & Target[1]

PDE1

150 μM (IC50)

PDE2

100 μM (IC50)

PDE3

0.35 μM (IC50)

PDE4

14 μM (IC50)

In Vivo

Olprinone (Loprinone) (0.2 mg/kg; i.p.) modulates the inflammation associated with myocardial ischemia-reperfusion injury in rats[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male adult Wistar rats (250-300 g) (ischemia–reperfusion rats)[1]
Dosage: 0.2 mg/kg
Administration: I.p. (administered 15 min after ischemia)
Result: Significantly reduced the: (1) histological evidence of myocardial injury, (2) pro-inflammatory cytokines: tumor necrosis factor-α (TNF-α) and Interleukin-1β (IL-1β), (3) adhesion molecules: Inter-Cellular Adhesion Molecule 1 (ICAM-1) and P-Selectin, (4) nitrotyrosine formation, (5) nuclear factor kappa-B (NF-κB) expression, (6) Poly (ADP-ribose) (PAR) formation, and (7) apoptosis (Bax, Bcl-2, Fas-L and terminal deoxynucleotidyl transferase-mediated UTP end labeling (TUNEL).
Molecular Weight

250.26

Formula

C14H10N4O

CAS No.
Appearance

Solid

Color

White to off-white

SMILES

CC(N1)=C(C=C(C#N)C1=O)C2=CN3C(C=C2)=NC=C3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 20.83 mg/mL (83.23 mM; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.9958 mL 19.9792 mL 39.9584 mL
5 mM 0.7992 mL 3.9958 mL 7.9917 mL
10 mM 0.3996 mL 1.9979 mL 3.9958 mL
*Please refer to the solubility information to select the appropriate solvent.
Purity & Documentation
References
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Olprinone Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
Olprinone
Cat. No.:
HY-14254A
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