1. Metabolic Enzyme/Protease
  2. Phosphodiesterase (PDE)
  3. Olprinone

Olprinone (Synonyms: Loprinone)

Cat. No.: HY-14254A
Handling Instructions

Olprinone (Loprinone) is a potent phosphodiesterase (PDE) 3 inhibitor, with IC50s of 150, 100, 0.35 and 14 μM for PDE1, PDE2, PDE3 and PDE4, respectively. Olprinone is used for the research of heart failure due to its positive inotropic and vasodilative effects. Anti-inflammatory activity.

For research use only. We do not sell to patients.

Olprinone Chemical Structure

Olprinone Chemical Structure

CAS No. : 106730-54-5

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Description

Olprinone (Loprinone) is a potent phosphodiesterase (PDE) 3 inhibitor, with IC50s of 150, 100, 0.35 and 14 μM for PDE1, PDE2, PDE3 and PDE4, respectively. Olprinone is used for the research of heart failure due to its positive inotropic and vasodilative effects. Anti-inflammatory activity[1][2].

IC50 & Target[1]

PDE1

150 μM (IC50)

PDE2

100 μM (IC50)

PDE3

0.35 μM (IC50)

PDE4

14 μM (IC50)

In Vivo

Olprinone (Loprinone) (0.2 mg/kg; i.p.) modulates the inflammation associated with myocardial ischemia-reperfusion injury in rats[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male adult Wistar rats (250-300 g) (ischemia–reperfusion rats)[1]
Dosage: 0.2 mg/kg
Administration: I.p. (administered 15 min after ischemia)
Result: Significantly reduced the: (1) histological evidence of myocardial injury, (2) pro-inflammatory cytokines: tumor necrosis factor-α (TNF-α) and Interleukin-1β (IL-1β), (3) adhesion molecules: Inter-Cellular Adhesion Molecule 1 (ICAM-1) and P-Selectin, (4) nitrotyrosine formation, (5) nuclear factor kappa-B (NF-κB) expression, (6) Poly (ADP-ribose) (PAR) formation, and (7) apoptosis (Bax, Bcl-2, Fas-L and terminal deoxynucleotidyl transferase-mediated UTP end labeling (TUNEL).
Molecular Weight

250.26

Formula

C₁₄H₁₀N₄O

CAS No.

106730-54-5

SMILES

CC(N1)=C(C=C(C#N)C1=O)C2=CN3C(C=C2)=NC=C3

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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

OlprinoneLoprinonePhosphodiesterase (PDE)heartfailurepositiveinotropicvasodilativeanti-inflammatorycytokineInhibitorinhibitorinhibit

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Olprinone
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