1. Metabolic Enzyme/Protease
  2. Phosphodiesterase (PDE)
  3. Olprinone

Olprinone  (Synonyms: Loprinone)

Cat. No.: HY-14254A Purity: 99.29%
COA Handling Instructions

Olprinone (Loprinone) is a potent phosphodiesterase (PDE) 3 inhibitor, with IC50s of 150, 100, 0.35 and 14 μM for PDE1, PDE2, PDE3 and PDE4, respectively. Olprinone is used for the research of heart failure due to its positive inotropic and vasodilative effects. Anti-inflammatory activity.

For research use only. We do not sell to patients.

Olprinone Chemical Structure

Olprinone Chemical Structure

CAS No. : 106730-54-5

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Description

Olprinone (Loprinone) is a potent phosphodiesterase (PDE) 3 inhibitor, with IC50s of 150, 100, 0.35 and 14 μM for PDE1, PDE2, PDE3 and PDE4, respectively. Olprinone is used for the research of heart failure due to its positive inotropic and vasodilative effects. Anti-inflammatory activity[1][2].

IC50 & Target[1]

PDE1

150 μM (IC50)

PDE2

100 μM (IC50)

PDE3

0.35 μM (IC50)

PDE4

14 μM (IC50)

In Vivo

Olprinone (Loprinone) (0.2 mg/kg; i.p.) modulates the inflammation associated with myocardial ischemia-reperfusion injury in rats[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male adult Wistar rats (250-300 g) (ischemia–reperfusion rats)[1]
Dosage: 0.2 mg/kg
Administration: I.p. (administered 15 min after ischemia)
Result: Significantly reduced the: (1) histological evidence of myocardial injury, (2) pro-inflammatory cytokines: tumor necrosis factor-α (TNF-α) and Interleukin-1β (IL-1β), (3) adhesion molecules: Inter-Cellular Adhesion Molecule 1 (ICAM-1) and P-Selectin, (4) nitrotyrosine formation, (5) nuclear factor kappa-B (NF-κB) expression, (6) Poly (ADP-ribose) (PAR) formation, and (7) apoptosis (Bax, Bcl-2, Fas-L and terminal deoxynucleotidyl transferase-mediated UTP end labeling (TUNEL).
Molecular Weight

250.26

Formula

C14H10N4O

CAS No.
Appearance

Solid

Color

White to off-white

SMILES

CC(N1)=C(C=C(C#N)C1=O)C2=CN3C(C=C2)=NC=C3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 20.83 mg/mL (83.23 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.9958 mL 19.9792 mL 39.9584 mL
5 mM 0.7992 mL 3.9958 mL 7.9917 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.9958 mL 19.9792 mL 39.9584 mL 99.8961 mL
5 mM 0.7992 mL 3.9958 mL 7.9917 mL 19.9792 mL
10 mM 0.3996 mL 1.9979 mL 3.9958 mL 9.9896 mL
15 mM 0.2664 mL 1.3319 mL 2.6639 mL 6.6597 mL
20 mM 0.1998 mL 0.9990 mL 1.9979 mL 4.9948 mL
25 mM 0.1598 mL 0.7992 mL 1.5983 mL 3.9958 mL
30 mM 0.1332 mL 0.6660 mL 1.3319 mL 3.3299 mL
40 mM 0.0999 mL 0.4995 mL 0.9990 mL 2.4974 mL
50 mM 0.0799 mL 0.3996 mL 0.7992 mL 1.9979 mL
60 mM 0.0666 mL 0.3330 mL 0.6660 mL 1.6649 mL
80 mM 0.0499 mL 0.2497 mL 0.4995 mL 1.2487 mL
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Olprinone Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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