106730-54-5
Chemical Structure
Olprinone
Synonym(s): Loprinone
- CAS No.: 106730-54-5
- Formula:C14H10N4O
- Molecular Weight:250.26
IUPAC Name: 5-(imidazo[1,2-a]pyridin-6-yl)-6-methyl-2-oxo-1,2-dihydropyridine-3-carbonitrile
InChIKey: JPAWFIIYTJQOKW-UHFFFAOYSA-N
SMILES: CC(N1)=C(C=C(C#N)C1=O)C2=CN3C(C=C2)=NC=C3
Biological Activity: Olprinone (Loprinone) is a potent phosphodiesterase (PDE) 3 inhibitor, with IC50s of 150, 100, 0.35 and 14 μM for PDE1, PDE2, PDE3 and PDE4, respectively. Olprinone is used for the research of heart failure due to its positive inotropic and vasodilative effects. Anti-inflammatory activity[1][2].
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Olprinone | 99.58% | Olprinone (Loprinone) is a potent phosphodiesterase (PDE) 3 inhibitor, with IC50s of 150, 100, 0.35 and 14 μM for PDE1, PDE2, PDE3 and PDE4, respectively. Olprinone is used for the research of heart failure due to its positive inotropic and vasodilative effects. Anti-inflammatory activity. | ||||||||||||||||||||
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Olprinone (Standard) | ≥98% | Olprinone (Standard) is the analytical standard of Olprinone. This product is intended for research and analytical applications. Olprinone (Loprinone) is a potent phosphodiesterase (PDE) 3 inhibitor, with IC50s of 150, 100, 0.35 and 14 μM for PDE1, PDE2, PDE3 and PDE4, respectively. Olprinone is used for the research of heart failure due to its positive inotropic and vasodilative effects. Anti-inflammatory activity. | ||||||||||||||||||||
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- [1]. Sugioka M, et al. Identification and characterization of isoenzymes of cyclic nucleotide phosphodiesterase in human kidney and heart, and the effects of new cardiotonic agents on these isoenzymes. Naunyn Schmiedebergs Arch Pharmacol. 1994;350(3):284-293. [Content Brief]
- [2]. Di Paola R, et al. Olprinone, a PDE3 inhibitor, modulates the inflammation associated with myocardial ischemia-reperfusion injury in rats. Eur J Pharmacol. 2011;650(2-3):612-620. [Content Brief]
Keywords
