1. Metabolic Enzyme/Protease
  2. Phosphodiesterase (PDE)
  3. Win-62005

Win-62005 

Cat. No.: HY-U00136
Handling Instructions

Win-62005 is a cyclic AMP phosphodiesterase III (PDE III) inhibitor with Kis of 25 and 26 nM for rat heart and canine aorta, respectively.

For research use only. We do not sell to patients.

Win-62005 Chemical Structure

Win-62005 Chemical Structure

CAS No. : 152633-54-0

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Description

Win-62005 is a cyclic AMP phosphodiesterase III (PDE III) inhibitor with Kis of 25 and 26 nM for rat heart and canine aorta, respectively.

IC50 & Target

Ki: 25 nM (PDE III), 25 nM (PDE III)[1]

In Vitro

Win-62005 competitively inhibits cyclic GMP-inhibitable low Km cyclic AMP phosphodiesterase (PDE III) from rat heart and canine aorta with Ki values of 25±3 and 26±5 nM, respectively and is selective (at least 160-fold) for PDE III inhibition relative to other PDE isozymes[1].

In Vivo

After p.o. administration of 1 mg/kg Win-62005, LVdP/dtmax is significantly increased in 30 min and remains increased for at least 6 h[1].

Molecular Weight

226.23

Formula

C₁₂H₁₀N₄O

CAS No.

152633-54-0

SMILES

O=C1NC2=NC(C)=C(C3=CC=NC=C3)C=C2N1

Shipping

Room temperature in continental US; may vary elsewhere

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Win-62005
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