2. Epigenetics Stem Cell/Wnt Protein Tyrosine Kinase/RTK JAK/STAT Signaling
  3. JAK
  4. Ritlecitinib tosylate

Ritlecitinib tosylate  (Synonyms: PF-06651600 tosylate)

Cat. No.: HY-100754C Purity: 99.77%
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Ritlecitinib tosylate is an orally active and selective?JAK3?inhibitor with an?IC50?of 33.1 nM. Ritlecitinib tosylate is used for inflammatory and autoimmune diseases research.

For research use only. We do not sell to patients.

Ritlecitinib tosylate Chemical Structure

Ritlecitinib tosylate Chemical Structure

CAS No. : 2192215-81-7

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Based on 5 publication(s) in Google Scholar

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Description

Ritlecitinib tosylate is an orally active and selective?JAK3?inhibitor with an?IC50?of 33.1 nM. Ritlecitinib tosylate is used for inflammatory and autoimmune diseases research[1].

Molecular Weight

457.55

Formula

C22H27N5O4S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

CC(C=C1)=CC=C1S(O)(=O)=O.C=CC(N2[C@@H](C)CC[C@@H](NC3=C4C(NC=C4)=NC=N3)C2)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 83.33 mg/mL (182.12 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1856 mL 10.9278 mL 21.8555 mL
5 mM 0.4371 mL 2.1856 mL 4.3711 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.1856 mL 10.9278 mL 21.8555 mL 54.6388 mL
5 mM 0.4371 mL 2.1856 mL 4.3711 mL 10.9278 mL
10 mM 0.2186 mL 1.0928 mL 2.1856 mL 5.4639 mL
15 mM 0.1457 mL 0.7285 mL 1.4570 mL 3.6426 mL
20 mM 0.1093 mL 0.5464 mL 1.0928 mL 2.7319 mL
25 mM 0.0874 mL 0.4371 mL 0.8742 mL 2.1856 mL
30 mM 0.0729 mL 0.3643 mL 0.7285 mL 1.8213 mL
40 mM 0.0546 mL 0.2732 mL 0.5464 mL 1.3660 mL
50 mM 0.0437 mL 0.2186 mL 0.4371 mL 1.0928 mL
60 mM 0.0364 mL 0.1821 mL 0.3643 mL 0.9106 mL
80 mM 0.0273 mL 0.1366 mL 0.2732 mL 0.6830 mL
100 mM 0.0219 mL 0.1093 mL 0.2186 mL 0.5464 mL
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Ritlecitinib tosylate Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ritlecitinib2192215-81-7PF-06651600PF06651600PF 06651600JAKJanus kinaseInhibitorinhibitorinhibit

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