2. Epigenetics Stem Cell/Wnt Protein Tyrosine Kinase/RTK Others JAK/STAT Signaling Immunology/Inflammation
  3. JAK Reference Standards Interleukin Related STAT
  4. Ritlecitinib tosylate (Standard)

Ritlecitinib tosylate (Standard)  (Synonyms: PF-06651600 tosylate (Standard))

Cat. No.: HY-100754CR Purity: 98%
Handling Instructions Technical Support

Ritlecitinib (tosylate) (Standard) is the analytical standard of Ritlecitinib (tosylate) (HY-100754C). This product is intended for research and analytical applications. Ritlecitinib (PF-06651600) tosylate is a highly selective, orally active, irreversible covalent JAK3 inhibitor (IC50=33 nM) without inhibitory activity towards JAK1, JAK2, and TYK2 (IC50 >10 μ M). Ritlecitinib tosylate rapidly inactivates the JAK3 kinase, and blocks signaling and downstream STAT phosphorylation mediated by common gamma chain cytokines such as IL-2 and IL-15. Ritlecitinib tosylate can inhibit Th1/Th17 cell differentiation and function, and effectively suppress preclinical animal models such as alopecia areata, adjuvant-induced arthritis (AIA), and experimental autoimmune encephalomyelitis (EAE).

For research use only. We do not sell to patients.

Ritlecitinib tosylate (Standard)

Ritlecitinib tosylate (Standard) Chemical Structure

CAS No. : 2192215-81-7

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5 mg Get quote 5 - 6 Weeks 4 - 5 Weeks 6 - 7 Weeks 5 - 6 weeks
10 mg Get quote 5 - 6 Weeks 4 - 5 Weeks 6 - 7 Weeks 5 - 6 weeks
25 mg Get quote 5 - 6 Weeks 4 - 5 Weeks 6 - 7 Weeks 5 - 6 weeks
50 mg Get quote 5 - 6 Weeks 4 - 5 Weeks 6 - 7 Weeks 5 - 6 weeks
100 mg Get quote 5 - 6 Weeks 4 - 5 Weeks 6 - 7 Weeks 5 - 6 weeks
200 mg   Get quote  
500 mg   Get quote  
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Information

Ritlecitinib (tosylate) (Standard) is the analytical standard of Ritlecitinib (tosylate) (HY-100754C). This product is intended for research and analytical applications. Ritlecitinib (PF-06651600) tosylate is a highly selective, orally active, irreversible covalent JAK3 inhibitor (IC50=33 nM) without inhibitory activity towards JAK1, JAK2, and TYK2 (IC50 >10 μ M). Ritlecitinib tosylate rapidly inactivates the JAK3 kinase, and blocks signaling and downstream STAT phosphorylation mediated by common gamma chain cytokines such as IL-2 and IL-15. Ritlecitinib tosylate can inhibit Th1/Th17 cell differentiation and function, and effectively suppress preclinical animal models such as alopecia areata, adjuvant-induced arthritis (AIA), and experimental autoimmune encephalomyelitis (EAE).

Application

The compound is the grade of analytical standard, which is the reference standard supplied assay. It is commonly used in qualitative, quantitative and methodological research experiments in HPLC, GC and MS.
Molecular Weight

457.55

Formula

C22H27N5O4S
CAS No.
SMILES

CC(C=C1)=CC=C1S(O)(=O)=O.C=CC(N2[C@@H](C)CC[C@@H](NC3=C4C(NC=C4)=NC=N3)C2)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Ritlecitinib tosylate (Standard) Related Classifications

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The dilution calculator equation

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This equation is commonly abbreviated as: C1V1 = C2V2

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ritlecitinib tosylate (Standard)2192215-81-7PF-06651600 tosylate (Standard)JAKReference StandardsInterleukin RelatedSTATJanus kinaseILInhibitorinhibitorinhibit

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