1. Epigenetics
    Stem Cell/Wnt
    JAK/STAT Signaling
  2. JAK
  3. (2R,5S)-Ritlecitinib

(2R,5S)-Ritlecitinib (Synonyms: (2R,5S)-PF-06651600)

Cat. No.: HY-100754B Purity: 98.83% ee.: 98.98%
Handling Instructions

(2R,5S)-Ritlecitinib ((2R,5S)-PF-06651600) is a potent and selective JAK3 inhibitor (IC50=144.8 nM) extracted from patent US20150158864A1, example 68.

For research use only. We do not sell to patients.

(2R,5S)-Ritlecitinib Chemical Structure

(2R,5S)-Ritlecitinib Chemical Structure

CAS No. : 1792180-79-0

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Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

(2R,5S)-Ritlecitinib ((2R,5S)-PF-06651600) is a potent and selective JAK3 inhibitor (IC50=144.8 nM) extracted from patent US20150158864A1, example 68[1].

IC50 & Target[1]

JAK3

144.8 nM (IC50)

Molecular Weight

285.34

Formula

C₁₅H₁₉N₅O

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 220 mg/mL (771.01 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.5046 mL 17.5230 mL 35.0459 mL
5 mM 0.7009 mL 3.5046 mL 7.0092 mL
10 mM 0.3505 mL 1.7523 mL 3.5046 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 5.5 mg/mL (19.28 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 5.5 mg/mL (19.28 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 5.5 mg/mL (19.28 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: 98.83% ee.: 98.98%

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Product Name:
(2R,5S)-Ritlecitinib
Cat. No.:
HY-100754B
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