2. Epigenetics
    Stem Cell/Wnt
    Protein Tyrosine Kinase/RTK
    JAK/STAT Signaling
  3. JAK
  4. (2R,5S)-Ritlecitinib

(2R,5S)-Ritlecitinib  (Synonyms: (2R,5S)-PF-06651600)

Cat. No.: HY-100754B Purity: 98.83% ee.: 98.98%
COA Handling Instructions

(2R,5S)-Ritlecitinib ((2R,5S)-PF-06651600) is a potent and selective JAK3 inhibitor (IC50=144.8 nM) extracted from patent US20150158864A1, example 68.

For research use only. We do not sell to patients.

(2R,5S)-Ritlecitinib Chemical Structure

(2R,5S)-Ritlecitinib Chemical Structure

CAS No. : 1792180-79-0

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of (2R,5S)-Ritlecitinib:

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Description

(2R,5S)-Ritlecitinib ((2R,5S)-PF-06651600) is a potent and selective JAK3 inhibitor (IC50=144.8 nM) extracted from patent US20150158864A1, example 68[1].

IC50 & Target[1]

JAK3

144.8 nM (IC50)

Molecular Weight

285.34

Appearance

Solid

Formula

C15H19N5O
CAS No.
SMILES

C[[email protected]@H]1CC[[email protected]@H](CN1C(C=C)=O)NC2=C3C=CNC3=NC=N2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Solvent & Solubility
In Vitro: 

DMSO : 220 mg/mL (771.01 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.5046 mL 17.5230 mL 35.0459 mL
5 mM 0.7009 mL 3.5046 mL 7.0092 mL
10 mM 0.3505 mL 1.7523 mL 3.5046 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 5.5 mg/mL (19.28 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 5.5 mg/mL (19.28 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 5.5 mg/mL (19.28 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation

Purity: 98.83% ee.: 98.98%

COA (252 KB) HNMR (252 KB) NP-HPLC (192 KB) LCMS (275 KB)

Handling Instructions (2659 KB)
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Molarity Calculator

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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Keywords:

(2R,5S)-Ritlecitinib1792180-79-0(2R,5S)-PF-06651600JAKJanus kinaseInhibitorinhibitorinhibit

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