1792180-79-0
1792180-79-0
Chemical Structure
(2R,5S)-Ritlecitinib
Synonym(s): (2R,5S)-PF-06651600
- CAS No.: 1792180-79-0
- Formula:C15H19N5O
- Molecular Weight:285.35
IUPAC Name: 1-((2R,5S)-5-((7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)-2-methylpiperidin-1-yl)prop-2-en-1-one
InChIKey: CBRJPFGIXUFMTM-MNOVXSKESA-N
SMILES: C[C@@H]1CC[C@@H](CN1C(C=C)=O)NC2=C3C=CNC3=NC=N2
Biological Activity: (2R,5S)-Ritlecitinib (2R,5S)-PF-06651600) is a JAK3 inhibitor (IC50=144.8 nM)[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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(2R,5S)-Ritlecitinib | 99.77% | (2R,5S)-Ritlecitinib (2R,5S)-PF-06651600) is a JAK3 inhibitor (IC50=144.8 nM). | ||||||||||||||||||||
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(2R,5S)-Ritlecitinib (Standard) | ≥98% | (2R,5S)-Ritlecitinib (Standard) is the analytical standard of (2R,5S)-Ritlecitinib (HY-100754B). This product is intended for research and analytical applications. (2R,5S)-Ritlecitinib (2R,5S)-PF-06651600) is a JAK3 inhibitor (IC50=144.8 nM). | ||||||||||||||||||||
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References
- [1]. Matthew Frank, et al. Pyrrolo[2,3-d]pyrimidinyl-, pyrrolo[2,3-b]pyrazinyl-and pyrrolo[2,3-d]pyridinylacrylamides as JAK inhibitor and their preparation. World Intellectual Property Organization, WO2015083028 A1 2015-06-11.
- [2]. Thorarensen A, et al. Design of a Janus Kinase 3 (JAK3) Specific Inhibitor 1-((2 S, 5 R)-5-((7 H-Pyrrolo [2, 3-d] pyrimidin-4-yl) amino)-2-methylpiperidin-1-yl) prop-2-en-1-one (PF-06651600) Allowing for the Interrogation of JAK3 Signaling in Humans. Journal of medicinal chemistry, 2017, 60(5): 1971-1993.
