2. Immunology/Inflammation
  3. COX
  4. Anti-inflammatory agent 53

Anti-inflammatory agent 53 (compound 7c) is an orally active selective COX-2 inhibitor. Anti-inflammatory agent 52 has anti-HT29 transfer activity, which leads to periodic arrest in S phase and G2/M phase. Anti-inflammatory agent 52 has safety, moderate ability to suppress inflammation. Anti-inflammatory agent 52 has a rare property of suppressing the development of tumor in mouse model, showing anti-cancer activity.

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Anti-inflammatory agent 53

Anti-inflammatory agent 53 Chemical Structure

CAS No. : 3052814-78-2

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Anti-inflammatory agent 53 Related Antibodies

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Description

Anti-inflammatory agent 53 (compound 7c) is an orally active selective COX-2 inhibitor. Anti-inflammatory agent 52 has anti-HT29 transfer activity, which leads to periodic arrest in S phase and G2/M phase. Anti-inflammatory agent 52 has safety, moderate ability to suppress inflammation. Anti-inflammatory agent 52 has a rare property of suppressing the development of tumor in mouse model, showing anti-cancer activity[1].

IC50 & Target

COX-2[1]
Cellular Effect
Cell Line Type Value Description References
A2780 IC50
0.67 μM
Compound: 7c
Cytotoxicity against human A2780 cells assessed as inhibition in cell growth incubated for 72 hrs by MTT assay
Cytotoxicity against human A2780 cells assessed as inhibition in cell growth incubated for 72 hrs by MTT assay
[PMID: 37567059]
HT-29 IC50
0.24 μM
Compound: 7c
Cytotoxicity against human HT-29 cells assessed as inhibition in cell growth incubated for 72 hrs by MTT assay
Cytotoxicity against human HT-29 cells assessed as inhibition in cell growth incubated for 72 hrs by MTT assay
[PMID: 37567059]
MCF7 IC50
1.51 μM
Compound: 7c
Cytotoxicity against human MCF7 cells assessed as inhibition in cell growth incubated for 72 hrs by MTT assay
Cytotoxicity against human MCF7 cells assessed as inhibition in cell growth incubated for 72 hrs by MTT assay
[PMID: 37567059]
MRC5 IC50
6.23 μM
Compound: 7c
Cytotoxicity against human MRC5 cells assessed as inhibition in cell growth incubated for 72 hrs by MTT assay
Cytotoxicity against human MRC5 cells assessed as inhibition in cell growth incubated for 72 hrs by MTT assay
[PMID: 37567059]
In Vitro

Anti-inflammatory agent 53 (compound 7c) (0.025 μM; 24 h) inhibits colonies formation of HT29 cells, arrests cell cycle at G2/M and S phase[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Anti-inflammatory agent 53 Related Antibodies
In Vivo

Anti-inflammatory agent 53 (compound 7c) (50 mg/kg; po; every other day for two weeks) decreasses the volume and weight of the tumors in Ehrlich solid carcinoma-bearing mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

434.51

Formula

C24H22N2O4S
CAS No.
SMILES

O=C(NC1=CC=C(OC)C=C1)COC2=CC=C(N3C(C4=CC=CC=C4)SCC3=O)C=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Anti-inflammatory agent 53 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-inflammatory agent 533052814-78-2COXCyclooxygenase4-ThiazolidinoneAnti-inflammatoryCOX activityCell cycle and apoptosisClonogenicity and cell migrationCytotoxicityDockingTubulin polymerizationInhibitorinhibitorinhibit

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