Anti-inflammatory agent 53
Anti-inflammatory agent 53 (compound 7c) is an orally active selective COX-2 inhibitor. Anti-inflammatory agent 52 has anti-HT29 transfer activity, which leads to periodic arrest in S phase and G2/M phase. Anti-inflammatory agent 52 has safety, moderate ability to suppress inflammation. Anti-inflammatory agent 52 has a rare property of suppressing the development of tumor in mouse model, showing anti-cancer activity.
For research use only. We do not sell to patients.
- CAS No.: 3052814-78-2
- Formula: C24H22N2O4S
- Molecular Weight:434.51
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
COX-2[1]
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A2780 | IC50 |
0.67 μM
Compound: 7c
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Cytotoxicity against human A2780 cells assessed as inhibition in cell growth incubated for 72 hrs by MTT assay
Cytotoxicity against human A2780 cells assessed as inhibition in cell growth incubated for 72 hrs by MTT assay
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[PMID: 37567059] |
| HT-29 | IC50 |
0.24 μM
Compound: 7c
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Cytotoxicity against human HT-29 cells assessed as inhibition in cell growth incubated for 72 hrs by MTT assay
Cytotoxicity against human HT-29 cells assessed as inhibition in cell growth incubated for 72 hrs by MTT assay
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[PMID: 37567059] |
| MCF7 | IC50 |
1.51 μM
Compound: 7c
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Cytotoxicity against human MCF7 cells assessed as inhibition in cell growth incubated for 72 hrs by MTT assay
Cytotoxicity against human MCF7 cells assessed as inhibition in cell growth incubated for 72 hrs by MTT assay
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[PMID: 37567059] |
| MRC5 | IC50 |
6.23 μM
Compound: 7c
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Cytotoxicity against human MRC5 cells assessed as inhibition in cell growth incubated for 72 hrs by MTT assay
Cytotoxicity against human MRC5 cells assessed as inhibition in cell growth incubated for 72 hrs by MTT assay
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[PMID: 37567059] |
Anti-inflammatory agent 53 (compound 7c) (0.025 μM; 24 h) inhibits colonies formation of HT29 cells, arrests cell cycle at G2/M and S phase[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 3052814-78-2
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Molecular Weight 434.51
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Formula C24H22N2O4S
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SMILES
O=C(NC1=CC=C(OC)C=C1)COC2=CC=C(N3C(C4=CC=CC=C4)SCC3=O)C=C2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Anti-inflammatory agent 53 Related Classifications
HY-155781 Related Classifications
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