Bryodulcosigenin (Synonyms: 11-Oxomogrol)

Cat. No.: HY-N4312: FAQs
Data Sheet SDS COA Handling Instructions

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Bryodulcosigenin is an extract of the roots of Bryoniadioica with anti-inflammatory effect.

For research use only. We do not sell to patients.

Bryodulcosigenin Chemical Structure

CAS No. : 88930-16-9

Size	Price	Stock
1 mg	USD 163	Ask For Quote & Lead Time
5 mg	USD 343	Ask For Quote & Lead Time

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This product is a controlled substance and not for sale in your territory.

1 Publications Citing Use of MCE Bryodulcosigenin

•Phytother Res. 2022 Jul 6. [Abstract]

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Biological Activity
Purity & Documentation
References
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Description

Bryodulcosigenin is an extract of the roots of Bryoniadioica with anti-inflammatory effect^[1].

Molecular Weight

474.72

Formula

C₃₀H₅₀O₄

CAS No.

88930-16-9

Appearance

Solid

Color

White to off-white

SMILES

C[C@]12[C@@]3([H])[C@]([C@@]4([H])C(C(C)([C@H](CC4)O)C)=CC3)(C(C[C@@]1([C@@](CC2)([H])[C@H](C)CC[C@@H](O)C(C)(O)C)C)=O)C

Structure Classification

Initial Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (210.65 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.1065 mL	10.5325 mL	21.0650 mL
5 mM	0.4213 mL	2.1065 mL	4.2130 mL
10 mM	0.2107 mL	1.0533 mL	2.1065 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (5.27 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 2

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.5 mg/mL (5.27 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Purity & Documentation

Purity: 98.66%

Select Batch:

Data Sheet (273 KB) SDS (252 KB)

COA (250 KB) HNMR (226 KB) LCMS (237 KB)

Handling Instructions (2659 KB)

References

[1]. Ukiya M, et al. Anti-inflammatory and anti-tumor-promoting effects of cucurbitane glycosides from the roots of Bryonia dioica. J Nat Prod. 2002 Feb;65(2):179-83. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.1065 mL	10.5325 mL	21.0650 mL	52.6626 mL
	5 mM	0.4213 mL	2.1065 mL	4.2130 mL	10.5325 mL
	10 mM	0.2107 mL	1.0533 mL	2.1065 mL	5.2663 mL
	15 mM	0.1404 mL	0.7022 mL	1.4043 mL	3.5108 mL
	20 mM	0.1053 mL	0.5266 mL	1.0533 mL	2.6331 mL
	25 mM	0.0843 mL	0.4213 mL	0.8426 mL	2.1065 mL
	30 mM	0.0702 mL	0.3511 mL	0.7022 mL	1.7554 mL
	40 mM	0.0527 mL	0.2633 mL	0.5266 mL	1.3166 mL
	50 mM	0.0421 mL	0.2107 mL	0.4213 mL	1.0533 mL
	60 mM	0.0351 mL	0.1755 mL	0.3511 mL	0.8777 mL
	80 mM	0.0263 mL	0.1317 mL	0.2633 mL	0.6583 mL
	100 mM	0.0211 mL	0.1053 mL	0.2107 mL	0.5266 mL

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Bryodulcosigenin88930-16-911-OxomogrolOthersInhibitorinhibitorinhibit

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