COX-2/PI3K-IN-2
COX-2/PI3K-IN-2 (compound 5f) is a potent PI3K inhibitor with IC50 value of 2.78 nM. COX-2/PI3K-IN-2 is a selective COX-2 inhibitor with Ki value of 3.02 nM. COX-2/PI3K-IN-2 shows anti-inflammatory and anti-cancer properties.
For research use only. We do not sell to patients.
- CAS No.: 2459938-28-2
- Formula: C16H17N5O2
- Molecular Weight:311.34
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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PI3K 2.78 nM (IC50) |
COX-2 3.02 nM (Ki) |
COX-2/PI3K-IN-2 (compound 5f) (50-500 µg/mL, 72 hours) exerts potent antitumor activities against Breast cancer (MCF-7) cells[1].
COX-2/PI3K-IN-2 (compound 5f) (10-150 µg/mL) has antioxidant properties with H2O2 scavenging activity equivalent to ascorbic acid and higher lysozyme inhibition (IC50=3.25 nM)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Breast cancer (MCF-7) cells and normal breast epithelial (MCF-10A) cells
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Concentration:50–500 µg/mL
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Incubation Time:72 hours
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Result:Caused 40 % cell death at 1.65 μM in MCF-7 cells.
Chemical Information
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CAS No. 2459938-28-2
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Molecular Weight 311.34
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Formula C16H17N5O2
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SMILES
O=C(/N=C1C(N(CCC)C2=C\1C=CC=C2)=O)NCN3C=CN=C3
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
COX-2/PI3K-IN-2 Related Classifications
HY-147912 Related Classifications
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